FI872637A - Disubstituerade piperaziner. - Google Patents

Disubstituerade piperaziner. Download PDF

Info

Publication number: FI872637A
Authority: FI; Finland
Prior art keywords: piperaziner; disubstituerade; alkylamino; piperazines; alkanoylamino
Prior art date: 1986-06-16

Application number

FI872637A

Other languages

English (en)

Other versions

FI872637A0 (fi

FI86545B (fi

FI86545C (fi

Inventor

Pier Giorgio Ferrini

Sprecher Andreas Von

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-16

Filing date

1987-06-12

Publication date

1987-12-17

1987-06-12 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1987-06-12 Publication of FI872637A0 publication Critical patent/FI872637A0/fi

1987-12-17 Publication of FI872637A publication Critical patent/FI872637A/fi

1992-05-29 Publication of FI86545B publication Critical patent/FI86545B/fi

1992-09-10 Application granted granted Critical

1992-09-10 Publication of FI86545C publication Critical patent/FI86545C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Lubricants (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Water Treatment By Sorption (AREA)
Removal Of Specific Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

FI872637A 1986-06-16 1987-06-12 Foerfarande foer framstaellning av terapeutiskt verkande 1-aroyl-4-aralkylpiperaziner. FI86545C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH242086		1986-06-16
CH242086		1986-06-16

Publications (4)

Publication Number	Publication Date
FI872637A0 FI872637A0 (fi)	1987-06-12
FI872637A true FI872637A (fi)	1987-12-17
FI86545B FI86545B (fi)	1992-05-29
FI86545C FI86545C (fi)	1992-09-10

Family

ID=4233392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI872637A FI86545C (fi)	1986-06-16	1987-06-12	Foerfarande foer framstaellning av terapeutiskt verkande 1-aroyl-4-aralkylpiperaziner.

Country Status (20)

Country	Link
US (1)	US4804661A (fi)
EP (1)	EP0250361B1 (fi)
JP (1)	JPS62298580A (fi)
KR (1)	KR880000410A (fi)
AT (1)	ATE98237T1 (fi)
AU (1)	AU603584B2 (fi)
DD (1)	DD263289A5 (fi)
DE (1)	DE3788373D1 (fi)
DK (1)	DK167187B1 (fi)
ES (1)	ES2060607T3 (fi)
FI (1)	FI86545C (fi)
HU (1)	HU202508B (fi)
IE (1)	IE61477B1 (fi)
IL (1)	IL82817A0 (fi)
MX (1)	MX6924A (fi)
MY (1)	MY102447A (fi)
NO (1)	NO169961C (fi)
PH (1)	PH23350A (fi)
PT (1)	PT85079B (fi)
ZA (1)	ZA874278B (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
IL85700A0 (en) *	1987-03-24	1988-08-31	Takeda Chemical Industries Ltd	1,4-disubstituted piperazine compounds,their production and use
EP0385043A1 (en) *	1989-02-28	1990-09-05	Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes)	New derivatives of 4-substituted piperazines
EP0489690A1 (de) *	1990-12-05	1992-06-10	Ciba-Geigy Ag	Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine
EP0524146A1 (de) *	1991-07-19	1993-01-20	Ciba-Geigy Ag	Aminosubstituierte Piperazinderivate
US5387595A (en) *	1992-08-26	1995-02-07	Merck & Co., Inc.	Alicyclic compounds as tachykinin receptor antagonists
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
US5384319A (en) *	1993-01-06	1995-01-24	Ciba-Geigy Corporation	Aminoalkylphenyl compounds
US5380726A (en) *	1993-01-15	1995-01-10	Ciba-Geigy Corporation	Substituted dialkylthio ethers
US5610165A (en) *	1994-02-17	1997-03-11	Merck & Co., Inc.	N-acylpiperidine tachykinin antagonists
JP6486198B2 (ja) *	2015-05-27	2019-03-20	国立大学法人宮崎大学	アンチモンイオンの抽出剤及びアンチモンイオンの回収方法
WO2023117119A1 (de) *	2021-12-23	2023-06-29	Symrise Ag	Wirkstoffe mit mundwässerndem und kribbelndem/prickelndem effekt und zubereitungen, die diese enthalten

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL105768C (fi) *	1959-02-25
US3000892A (en) *	1959-11-16	1961-09-19	Paul A J Janssen	1-aroylalkyl-4-aroylpiperazines
FR7170M (fi) *	1966-12-28	1969-08-11
CH590261A5 (fi) *	1973-07-10	1977-07-29	Ciba Geigy Ag
US3917617A (en) *	1973-10-01	1975-11-04	Sharps Ass	1-{8 2,6-Dihydroxy-4-hydrocarbyl-benzoyl{9 polymethyleneimines and derivatives
JPS50151885A (fi) *	1974-05-29	1975-12-06
CY1344A (en) *	1978-08-10	1987-01-16	Ciba Geigy Ag	Substituted anthranilic acid amides,process for their preparation,and pharmaceutical compositions containing them
WO1981003658A1 (en) *	1980-06-16	1981-12-24	Ferrosan Ab	Diphenylbutyl-1-acylpiperazines
FR2522325B1 (fr) *	1982-02-26	1985-08-09	Delalande Sa	Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique
AU545463B2 (en) *	1982-06-25	1985-07-18	Kowa Co. Ltd.	Benzoyl piperacine esters
IT1176613B (it) *	1984-08-14	1987-08-18	Ravizza Spa	Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
IL85700A0 (en) *	1987-03-24	1988-08-31	Takeda Chemical Industries Ltd	1,4-disubstituted piperazine compounds,their production and use

1987
- 1987-05-26 MY MYPI87000720A patent/MY102447A/en unknown
- 1987-06-09 US US07/059,898 patent/US4804661A/en not_active Expired - Fee Related
- 1987-06-09 IL IL82817A patent/IL82817A0/xx not_active IP Right Cessation
- 1987-06-10 EP EP87810331A patent/EP0250361B1/de not_active Expired - Lifetime
- 1987-06-10 AT AT87810331T patent/ATE98237T1/de not_active IP Right Cessation
- 1987-06-10 DE DE87810331T patent/DE3788373D1/de not_active Expired - Fee Related
- 1987-06-10 ES ES87810331T patent/ES2060607T3/es not_active Expired - Lifetime
- 1987-06-12 MX MX692487A patent/MX6924A/es unknown
- 1987-06-12 FI FI872637A patent/FI86545C/fi not_active IP Right Cessation
- 1987-06-15 HU HU872710A patent/HU202508B/hu not_active IP Right Cessation
- 1987-06-15 PT PT85079A patent/PT85079B/pt not_active IP Right Cessation
- 1987-06-15 AU AU74219/87A patent/AU603584B2/en not_active Ceased
- 1987-06-15 JP JP62147163A patent/JPS62298580A/ja active Granted
- 1987-06-15 PH PH35398A patent/PH23350A/en unknown
- 1987-06-15 DD DD87303827A patent/DD263289A5/de not_active IP Right Cessation
- 1987-06-15 ZA ZA874278A patent/ZA874278B/xx unknown
- 1987-06-15 DK DK303387A patent/DK167187B1/da not_active Application Discontinuation
- 1987-06-15 NO NO872480A patent/NO169961C/no unknown
- 1987-06-15 IE IE158287A patent/IE61477B1/en not_active IP Right Cessation
- 1987-06-15 KR KR1019870006034A patent/KR880000410A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUT44529A (en)	1988-03-28
AU603584B2 (en)	1990-11-22
DD263289A5 (de)	1988-12-28
DK303387D0 (da)	1987-06-15
EP0250361B1 (de)	1993-12-08
PH23350A (en)	1989-07-14
ATE98237T1 (de)	1993-12-15
JPH0579065B2 (fi)	1993-11-01
AU7421987A (en)	1987-12-17
DE3788373D1 (de)	1994-01-20
NO872480D0 (no)	1987-06-15
FI872637A0 (fi)	1987-06-12
PT85079B (pt)	1990-03-08
IE61477B1 (en)	1994-11-02
JPS62298580A (ja)	1987-12-25
MX6924A (es)	1993-12-01
ES2060607T3 (es)	1994-12-01
FI86545B (fi)	1992-05-29
FI86545C (fi)	1992-09-10
KR880000410A (ko)	1988-03-25
NO872480L (no)	1987-12-17
HU202508B (en)	1991-03-28
NO169961C (no)	1992-08-26
ZA874278B (en)	1987-12-15
MY102447A (en)	1992-06-30
EP0250361A2 (de)	1987-12-23
IL82817A0 (en)	1987-12-20
US4804661A (en)	1989-02-14
PT85079A (en)	1987-07-01
EP0250361A3 (en)	1990-01-31
NO169961B (no)	1992-05-18
DK167187B1 (da)	1993-09-13
IE871582L (en)	1987-12-16
DK303387A (da)	1987-12-17

Publication	Publication Date	Title
ATE53023T1 (de)	1990-06-15	5-acylamido-1-aryl-pyrazole.
KR870700619A (ko)	1987-12-30	피콜린 유도체 및 그 제조방법 및 그 용도 및 그를 포함한 약제
SE8700498D0 (sv)	1987-02-10	Novel pharmaceologically active compounds
FI872637A0 (fi)	1987-06-12	Disubstituerade piperaziner.
NO900202D0 (no)	1990-01-15	Nye diazoler.
FI853624A0 (fi)	1985-09-20	1-substituerade tetralinderivat, deras framstaellning och anvaendning.
DK23386D0 (da)	1986-01-17	Pyridopyrimidiner, deres fremstilling og anvendelse som laegemidler
DK0481299T3 (da)	1994-09-12	N-phenyl-piperidyl-4-aminer og lægemidler indeholdende disse
IT8323122A0 (it)	1983-10-04	Forma galenica del sulpiride, suo procedimento di preparazione e medicamento comprendente questa forma.
DK313587A (da)	1987-12-22	Tetrahydrobenzothiazolforbindelser, deres fremstilling og anvendelse
ES8801895A1 (es)	1988-03-01	Procedimiento para la obtencion de benzamidas
ES557647A0 (es)	1988-02-16	Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo
ES554115A0 (es)	1988-05-01	Procedimiento de preparacion de derivados del triazol y de sus sales de adicion con los acidos apropiados
DK401683A (da)	1984-03-05	Substituerede benzensulfonsyreestere, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
NO158803C (no)	1988-11-09	Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n-(3-trifluormetylfenyl)-n[-propargylpiperazin.
DK10187D0 (da)	1987-01-09	Methioninsubstituerede 1,4-dihydropuyridiner, deres fremstilling og anvendelse som laegemidler
GB1153648A (en)	1969-05-29	Substituted 2-Anilino Benzothiazole Basic Ethers
KR910009654A (ko)	1991-06-28	아미노피리딘, 아닐린 및 피콜릴아민의 피콜릴셀레노벤즈아미드
DK474984A (da)	1985-04-15	N-(4-acetylaminophenacyl)-aminderivater, deres terapeutiske anvendelse og deres fremstilling
DE3674060D1 (de)	1990-10-18	Pharmacologisch aktive propionylanilide.
IT8323838A0 (it)	1983-11-23	Procedimento per la preparazione del 4-idrossi-2-metil-2h-1,2benzotiazina-3-[n-(2-piridil)carbossammide]-1,1-diossido

Legal Events

Date	Code	Title	Description
1997-01-15	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: CIBA-GEIGY AG