FI87230B - Serumfritt vaextmedium och dess anvaendning. - Google Patents
Serumfritt vaextmedium och dess anvaendning. Download PDFInfo
- Publication number
- FI87230B FI87230B FI875793A FI875793A FI87230B FI 87230 B FI87230 B FI 87230B FI 875793 A FI875793 A FI 875793A FI 875793 A FI875793 A FI 875793A FI 87230 B FI87230 B FI 87230B
- Authority
- FI
- Finland
- Prior art keywords
- serum
- plant medium
- concentration
- medium according
- free plant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (11)
1. Serumfritt växtmedium bestäende av ett basalmedium för cel 1kulturer, säsom RPMI 1640/HEPES/NaHC03 samt eventuellt spärämnen som är nödvändiga för cellväxt, säsom Zn, Cu, Mn, Ni, Ai, Cr, Co och/eller Se, vilket växtmedium är buffrat i ett pH-omräde inom 7,0 - 7,8, kännetecknat därav, att växtmediet ytterligare bestär av ett otoxiskt järnkelat, där järnets koncentration är 1 - 10 μΜ, samt ett överskott av en eller fler i och för sig kända, otoxiska kelatorer och citronsyra/citrat i en koncentration, som är minst tre gänger sä stor som den totala koncentrationen av kelatorerna, samt aurintrikarboxylsyra 0,5 - 6 μΜ.
2. Serumfritt växtmedium enligt patentkravet 1, kännetecknat därav, att aurintrikarboxylsyrans koncentration är 2,4 - 3,6 μΜ.
3. Serumfritt växtmedium enligt patentkravet 1 eller 2, kännetecknat därav, att eventuella spärämnen före-ligger i sädana mängd, att koncentrationen av kelator/kela-torblandningen är 300 - 300 000 gänger större än koncentrationen av de enskilda spärämnena.
4. Serumfritt växtmedium enligt nägot av patentkraven 1-3, kännetecknat därav , att det innehäller ett eller flera ytaktiva ämnen.
5. Serumfritt växtmedium enligt nägot av patentkraven 1-3, kännetecknat därav, att det ytterligare innehäller växtfaktorer säsom D-glukos, L-glutamin, Na-pyruvat, insulin och etanolamin.
6. Serumfritt växtmedium enligt patentkravet 5, kännetecknat därav, att det ytterligare innehäller växtfaktorer, säsom vitaminer och icke-proteiniska hormoner. 87230
7. Serumfritt växtmedium enligt nägot av patentkraven 1-6, kännetecknat därav, att det innehäller ett basal-medium med en koncentration pä 2,5 g/1 NaHC03 och 20 mM HEPES.
8. Serumfritt växtmedium enligt nägot av patentkraven 1-7, kännetecknat därav, att den använda kelatorn är EDTA.
9. Koncentrat av serumfritt växtmedium för användning tili framställning av vattenhaltigt serumfritt växtmedium enligt nägot av patentkraven 1-6, kännetecknat därav, att det bestär av ett koncentrat av enskilda beständsdelar, företrädesvis 1000 gängers koncentration, bestäende av 2.4 - 3,6 mM Fe-EDTA och 0,2 - 1,2 mM Na2 EDTA samt 32 - 48 mM citronsyra/citrat, 0,5 - 6 mM, företrädesvis 2.4 - 3,6 mM, aurintrikarboksylsyra, samt eventuellt metall- joner inom koncentrationsinterval1ena 0,08 - 0,12 mM Zn* , 0,016 - 0,024 mM Cu2+, 0,0008 - 0,0012 mM Mn2+, 0,00016 - 0,00024 mM Ni2+, 0,0016 - 0,0024 mM Al3+, 0,0008 - 0,0012 mM Cr3+, 0,00016 - 0,00024 mM Co2+ och 0,008 - 0,012 mM Se*+, vilken blandning är buffrad i pH-om- rädet 4,5 - 5,0.
10. Koncentrat av ett serumfritt växtmedium enligt patent-kravet 9, kännetecknat därav, att det föreligger i form av en torrämnesblandning.
11. Användningen av ett serumfritt växtmedium enligt nägot av patentkraven 1-7 för undersökning av växtmediumkvalitet, företrädesvis genom användning av cellinjen ECACC 86112001, deponerad vid The European Collection for Animal Cell Cultures den 20 november 1986.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO870095A NO162160C (no) | 1987-01-09 | 1987-01-09 | Serumfritt vekstmedium, samt anvendelse derav. |
| NO870095 | 1987-01-09 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI875793A0 FI875793A0 (fi) | 1987-12-31 |
| FI875793A FI875793A (fi) | 1988-07-10 |
| FI87230B true FI87230B (fi) | 1992-08-31 |
| FI87230C FI87230C (sv) | 1992-12-10 |
Family
ID=19889567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI875793A FI87230C (sv) | 1987-01-09 | 1987-12-31 | Serumfritt växtmedium och dess användning |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5045467A (sv) |
| EP (1) | EP0274445B1 (sv) |
| JP (2) | JPH0697996B2 (sv) |
| KR (1) | KR880009124A (sv) |
| AT (1) | ATE92098T1 (sv) |
| AU (1) | AU596491B2 (sv) |
| BR (1) | BR8800040A (sv) |
| CA (1) | CA1321961C (sv) |
| DE (1) | DE3882540T2 (sv) |
| DK (1) | DK169765B1 (sv) |
| ES (1) | ES2008411A6 (sv) |
| FI (1) | FI87230C (sv) |
| IL (1) | IL85026A (sv) |
| IT (1) | IT1215675B (sv) |
| NO (1) | NO162160C (sv) |
| NZ (1) | NZ223139A (sv) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1307486C (en) * | 1987-10-29 | 1992-09-15 | Michael T. Largen | Hybridoma production |
| SE8801537D0 (sv) * | 1988-04-26 | 1988-04-26 | Ellco Food Ab | Cellodlingsmedium samt forfarande for dess framstellning |
| JPH03180175A (ja) * | 1989-12-07 | 1991-08-06 | Snow Brand Milk Prod Co Ltd | 無血清培地 |
| US5378612A (en) * | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| WO1993000423A1 (en) * | 1991-06-21 | 1993-01-07 | Novo Nordisk A/S | Iron chelate culture medium additive |
| GB9215834D0 (en) * | 1992-07-24 | 1992-09-09 | Celltech Ltd | Cell culture |
| DE4313620A1 (de) * | 1993-04-26 | 1994-10-27 | Biotechnolog Forschung Gmbh | Hamsterzellinien und Verfahren zur Glykoproteingewinnung |
| US5434185A (en) * | 1993-05-17 | 1995-07-18 | The University Of Kentucky Research Foundation | Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts |
| US5405772A (en) * | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
| US5846529A (en) * | 1993-08-23 | 1998-12-08 | Nexell Therapeutics, Inc. | Infusion of neutrophil precursors for treatment of neutropenia |
| US6037174A (en) * | 1993-08-23 | 2000-03-14 | Nexell Therapeutics, Inc. | Preparation of serum-free suspensions of human hematopoietic cells or precursor cells |
| US5395822A (en) * | 1993-09-20 | 1995-03-07 | Izumi; Yukitoshi | Use of pyruvate to prevent neuronal degeneration associated with ischemia |
| US5593880A (en) * | 1994-02-10 | 1997-01-14 | Viratest International, Inc. | Dual-state nutritional medium for the transport and maintenance of cells |
| US5908782A (en) * | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US6733746B2 (en) | 1996-03-12 | 2004-05-11 | Invitrogen Corporation | Hematopoietic cell culture nutrient supplement |
| US6043092A (en) * | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
| US6511848B2 (en) * | 1996-04-17 | 2003-01-28 | Winfried Albert | Process for producing and multiplying lymphocytes |
| AU4330597A (en) * | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| US6833271B2 (en) * | 1996-12-04 | 2004-12-21 | Medi-Cult A/S | Serum-free cell culture media |
| GB9625175D0 (en) * | 1996-12-04 | 1997-01-22 | Medi Cult As | Serum-free cell culture media |
| US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6541256B1 (en) | 1999-02-11 | 2003-04-01 | The Schepens Eye Research Institute, Inc. | Growth medium for human corneal endothelial cells |
| ATE384120T1 (de) * | 1999-08-27 | 2008-02-15 | Invitrogen Corp | Metallbindende verbindungen und deren verwendung in zusammensetzungen für zellkulturmedien |
| US6767741B1 (en) * | 1999-08-27 | 2004-07-27 | Invitrogen Corporation | Metal binding compounds and their use in cell culture medium compositions |
| GB0003231D0 (en) * | 2000-02-11 | 2000-04-05 | Medi Cult As | Cell culture media |
| US20030096414A1 (en) * | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
| WO2002099070A2 (en) * | 2001-06-04 | 2002-12-12 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| US7087369B2 (en) * | 2003-12-17 | 2006-08-08 | The Regents Of The University Of California | Cornea preservation medium |
| US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
| US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| PL1807504T3 (pl) | 2004-11-02 | 2011-07-29 | Ares Trading Sa | Bezsurowicza pożywka hodowlana dla komórek ssaczych |
| US8273553B2 (en) | 2004-11-02 | 2012-09-25 | Ares Trading S.A. | Production of growth hormone in serum-free cell culture medium for mammalian cells |
| WO2006071563A2 (en) | 2004-12-23 | 2006-07-06 | Medimmune Vaccines, Inc. | Non-tumorigenic mdck cell line for propagating viruses |
| EP1917276B1 (en) | 2005-08-26 | 2018-03-21 | Ares Trading S.A. | Process for the preparation of glycosylated interferon beta |
| AU2007205522B2 (en) | 2006-01-13 | 2011-08-11 | Two Cells Co., Ltd. | Additive for culture medium for use in serum-free culture of animal cell, kit, and use of the additive or kit |
| ES2668212T3 (es) * | 2006-07-13 | 2018-05-17 | Wyeth Llc | Producción de factor de coagulación IX con patrón de glucosilación mejorado |
| CN103361319A (zh) | 2006-09-15 | 2013-10-23 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| US8361741B2 (en) * | 2007-08-29 | 2013-01-29 | Millipore Corporation | Serum-free growth medium for Acholeplasma laidlawii and methods for retention testing sterilizing grade filters |
| CA2738024A1 (en) | 2008-09-24 | 2010-04-01 | Medimmune, Llc | Methods for purification of viruses |
| US20110212523A1 (en) * | 2008-11-11 | 2011-09-01 | Yukio Kato | Differentiation-inducing culture medium additive and use thereof |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| JP5804385B2 (ja) | 2010-03-10 | 2015-11-04 | 株式会社ツーセル | 間葉系幹細胞を含む細胞製剤及びその製造方法 |
| KR102136698B1 (ko) | 2012-05-02 | 2020-07-22 | 라이프 테크놀로지스 코포레이션 | 고밀도 성장 및 형질감염 배지 및 발현 인핸서의 독특한 페어링을 사용하는 포유동물 세포들 내의 고수율의 일시적 발현 |
| CA2942770A1 (en) * | 2014-03-23 | 2015-10-01 | Advantech Bioscience Farmaceutica Ltda. | Enhancement of recombinant protein expression with copper |
| TW201630622A (zh) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | 速效胰島素組合物 |
| US10119117B2 (en) | 2016-01-28 | 2018-11-06 | Nanogen Pharmaceutical Biotechnology Co., Ltd | Universal, glycosylation enhancer, completely chemically defined medium formulation |
| WO2018178063A1 (en) * | 2017-03-31 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Perfusion medium |
| CN110835622B (zh) * | 2018-08-16 | 2021-04-27 | 上海药明生物技术有限公司 | 用于调节哺乳动物细胞乳酸代谢的培养基及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466917A (en) * | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| US4544632A (en) * | 1981-06-12 | 1985-10-01 | Yuichi Yamamura | Human T cell lines and method of producing same |
| IL65765A (en) * | 1982-05-13 | 1985-09-29 | Israel State | Method of preventing virus replication in plants |
| US4604284A (en) * | 1983-09-20 | 1986-08-05 | Hoffmann-La Roche Inc. | Homogeneous immune interferon fragment |
| EP0156169B1 (en) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method |
| JPS6158584A (ja) * | 1984-08-30 | 1986-03-25 | Ube Ind Ltd | 細胞増殖促進剤及び細胞増殖促進方法 |
| JP2967117B2 (ja) * | 1989-03-14 | 1999-10-25 | 旭化成工業株式会社 | 電子線硬化型導電性ペースト組成物 |
-
1987
- 1987-01-09 NO NO870095A patent/NO162160C/no not_active IP Right Cessation
- 1987-12-22 DK DK678687A patent/DK169765B1/da not_active IP Right Cessation
- 1987-12-24 KR KR1019870014892A patent/KR880009124A/ko not_active Application Discontinuation
- 1987-12-31 FI FI875793A patent/FI87230C/sv not_active IP Right Cessation
-
1988
- 1988-01-05 IL IL8502688A patent/IL85026A/xx not_active IP Right Cessation
- 1988-01-07 AU AU10115/88A patent/AU596491B2/en not_active Ceased
- 1988-01-07 BR BR8800040A patent/BR8800040A/pt not_active IP Right Cessation
- 1988-01-08 JP JP236888A patent/JPH0697996B2/ja not_active Expired - Fee Related
- 1988-01-08 NZ NZ22313988A patent/NZ223139A/xx unknown
- 1988-01-08 ES ES8800030A patent/ES2008411A6/es not_active Expired
- 1988-01-08 CA CA 556106 patent/CA1321961C/en not_active Expired - Fee Related
- 1988-01-08 IT IT1902488A patent/IT1215675B/it active
- 1988-01-08 AT AT88300121T patent/ATE92098T1/de not_active IP Right Cessation
- 1988-01-08 EP EP19880300121 patent/EP0274445B1/en not_active Expired - Lifetime
- 1988-01-08 DE DE88300121T patent/DE3882540T2/de not_active Expired - Lifetime
- 1988-01-11 US US07/142,069 patent/US5045467A/en not_active Expired - Lifetime
-
1990
- 1990-02-23 US US07/484,557 patent/US5045454A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 JP JP5256094A patent/JP2524313B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL85026A0 (en) | 1988-06-30 |
| JPS63279786A (ja) | 1988-11-16 |
| BR8800040A (pt) | 1988-08-02 |
| EP0274445A2 (en) | 1988-07-13 |
| JP2524313B2 (ja) | 1996-08-14 |
| ES2008411A6 (es) | 1989-07-16 |
| DK678687D0 (da) | 1987-12-22 |
| DK169765B1 (da) | 1995-02-20 |
| IT8819024A0 (it) | 1988-01-08 |
| FI875793A (fi) | 1988-07-10 |
| NO870095L (no) | 1988-07-11 |
| CA1321961C (en) | 1993-09-07 |
| US5045467A (en) | 1991-09-03 |
| IL85026A (en) | 1992-09-06 |
| FI875793A0 (fi) | 1987-12-31 |
| KR880009124A (ko) | 1988-09-14 |
| DE3882540D1 (de) | 1993-09-02 |
| JPH06292570A (ja) | 1994-10-21 |
| ATE92098T1 (de) | 1993-08-15 |
| NZ223139A (en) | 1991-09-25 |
| EP0274445A3 (en) | 1989-12-13 |
| JPH0697996B2 (ja) | 1994-12-07 |
| AU596491B2 (en) | 1990-05-03 |
| NO162160C (no) | 1989-11-15 |
| DK678687A (da) | 1988-07-10 |
| AU1011588A (en) | 1988-07-14 |
| NO162160B (no) | 1989-08-07 |
| EP0274445B1 (en) | 1993-07-28 |
| IT1215675B (it) | 1990-02-22 |
| DE3882540T2 (de) | 1993-11-18 |
| US5045454A (en) | 1991-09-03 |
| FI87230C (sv) | 1992-12-10 |
| NO870095D0 (no) | 1987-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: MEDI-CULT A/S |
|
| MA | Patent expired |