FI870808A - 9-alfa, 11-beta-substituerade och 11-beta-substituerade estraner. - Google Patents

9-alfa, 11-beta-substituerade och 11-beta-substituerade estraner. Download PDF

Info

Publication number: FI870808A
Authority: FI; Finland
Prior art keywords: beta; substituerade; alpha; estraner; och
Prior art date: 1985-06-25

Application number

FI870808A

Other languages

English (en)

Other versions

FI88509C (fi

FI88509B (fi

FI870808A0 (fi

Inventor

David Franklin Crowe

Masato Tanabe

Richard H Peters

Original Assignee

Stanford Res Inst Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-25

Filing date

1987-02-25

Publication date

1987-02-25

1987-02-25 Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int

1987-02-25 Publication of FI870808A0 publication Critical patent/FI870808A0/fi

1987-02-25 Publication of FI870808A publication Critical patent/FI870808A/fi

1993-02-15 Application granted granted Critical

1993-02-15 Publication of FI88509B publication Critical patent/FI88509B/fi

1993-05-25 Publication of FI88509C publication Critical patent/FI88509C/fi

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Steroid Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Compounds Of Unknown Constitution (AREA)
Liquid Crystal Substances (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Silicon Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

FI870808A 1985-06-25 1987-02-25 9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner FI88509C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US74848985		1985-06-25
US06/748,489 US4705783A (en)	1985-06-25	1985-06-25	9α, 11β-substituted and 11β-substituted estranes
US8601358		1986-06-24
PCT/US1986/001358 WO1987000175A1 (en)	1985-06-25	1986-06-24	9alpha, 11beta-SUBSTITUTED AND 11beta-SUBSTITUTED ESTRANES

Publications (4)

Publication Number	Publication Date
FI870808A0 FI870808A0 (fi)	1987-02-25
FI870808A true FI870808A (fi)	1987-02-25
FI88509B FI88509B (fi)	1993-02-15
FI88509C FI88509C (fi)	1993-05-25

Family

ID=25009663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI870808A FI88509C (fi)	1985-06-25	1987-02-25	9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner

Country Status (9)

Country	Link
US (3)	US4705783A (fi)
EP (1)	EP0227813B1 (fi)
JP (1)	JPH0816117B2 (fi)
AT (1)	ATE68001T1 (fi)
DE (1)	DE3681786D1 (fi)
DK (1)	DK98087D0 (fi)
FI (1)	FI88509C (fi)
NO (1)	NO870759L (fi)
WO (1)	WO1987000175A1 (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0263569B1 (en) *	1986-10-10	1992-12-09	Roussel-Uclaf	9-alpha-hydroxysteroids, process for their preparation and process for the preparation of the corresponding 9(11)-dehydro-derivatives.
US5137882A (en) *	1990-06-11	1992-08-11	Holt Dennis A	Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
US5554603A (en) *	1993-09-17	1996-09-10	The United States Of America As Represented By The Department Of Health And Human Services	Orally active derivatives of 1,3,5(10)-estratriene
US6083528A (en) *	1995-09-28	2000-07-04	Schering Aktiengesellschaft	Hormone replacement therapy method and hormone dispenser
US5897539A (en) *	1995-09-28	1999-04-27	Schering Aktiengesellschaft	Hormone replacement therapy method and hormone dispenser
US6551611B2 (en)	1995-09-28	2003-04-22	Schering Aktiengesellschaft	Hormone replacement therapy method
US6548491B2 (en)	1997-12-24	2003-04-15	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en)	1997-12-24	2003-01-07	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6054446A (en) *	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19906159A1 (de) *	1999-02-09	2000-08-10	Schering Ag	16-Hydroxyestratriene als selektiv wirksame Estrogene
US20050282791A1 (en) *	1999-11-02	2005-12-22	Alexander Hillisch	18-nor steroids as selectively active estrogens
ES2286042T3 (es) *	1999-11-02	2007-12-01	Bayer Schering Pharma Aktiengesellschaft	18-nor-esteroides como estrogenos eficaces selectivamente.
US6958327B1 (en)	1999-11-02	2005-10-25	Schering, Ag	18 Norsteroids as selectively active estrogens
US8173628B2 (en) *	2000-06-22	2012-05-08	Northeastern University	Steroidal antiestrogens and antiandrogens and uses thereof
WO2001098322A1 (en) *	2000-06-22	2001-12-27	Northeastern University	Novel steroidal antiestrogens and antiandrogens and uses thereof
WO2002022645A2 (en) *	2000-09-14	2002-03-21	Accelerated Pharmaceuticals, Inc.	Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity
DE10233723A1 (de) *	2002-07-24	2004-02-12	Schering Ag	Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
WO2004098538A2 (en) *	2003-03-13	2004-11-18	Nitromed, Inc.	Nitrosated and nitrosylated compounds, compositions and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE649225A (fi) *	1963-06-12
GB1074493A (en) *	1963-06-12	1967-07-05	Roussel Uclaf	Novel estrane derivatives and processes for preparing them
FR5519M (fi) *	1966-06-07	1967-11-06
US3411567A (en) *	1966-06-13	1968-11-19	United Eng Foundry Co	Mold supporting structure for casting machine
FR6854M (fi) *	1967-12-15	1969-04-08
US3980681A (en) *	1969-11-21	1976-09-14	Peter Job Sykes	Process for the preparation of 11-β-nitro-oxysteroids
US3755574A (en) *	1971-01-21	1973-08-28	Roussel Uclaf	Estrogenic compositions comprising 11beta-alkoxy-gona-1,3,5(10)-trienes
US3906096A (en) *	1971-11-23	1975-09-16	Roussel Uclaf	Novel 11{62 -alkoxy steroids
US3755301A (en) *	1972-06-23	1973-08-28	Searle & Co	Manufacture of 11-alkyl steroids
NL7405626A (nl) *	1974-04-26	1975-10-28	Akzo Nv	Nieuwe 11-gesubstitueerde steroiden van de oestraanreeks.
NL7613248A (nl) *	1976-11-26	1978-05-30	Akzo Nv	Werkwijze voor het bereiden van nieuwe steroid- esters.
DE3248434A1 (de) *	1982-12-23	1984-06-28	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von 3,11(alpha)-dihydroxy-1,3,5(10)-oestratrien-derivaten

1985
- 1985-06-25 US US06/748,489 patent/US4705783A/en not_active Ceased
1986
- 1986-06-24 WO PCT/US1986/001358 patent/WO1987000175A1/en active IP Right Grant
- 1986-06-24 AT AT86904572T patent/ATE68001T1/de not_active IP Right Cessation
- 1986-06-24 EP EP86904572A patent/EP0227813B1/en not_active Expired - Lifetime
- 1986-06-24 JP JP61503719A patent/JPH0816117B2/ja not_active Expired - Lifetime
- 1986-06-24 DE DE8686904572T patent/DE3681786D1/de not_active Expired - Lifetime
1987
- 1987-02-24 NO NO870759A patent/NO870759L/no unknown
- 1987-02-25 DK DK098087A patent/DK98087D0/da not_active Application Discontinuation
- 1987-02-25 FI FI870808A patent/FI88509C/fi not_active IP Right Cessation
- 1987-08-24 US US07/088,802 patent/US4859370A/en not_active Expired - Fee Related
1989
- 1989-11-09 US US07/434,849 patent/USRE34136E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI88509C (fi)	1993-05-25
US4705783A (en)	1987-11-10
DK98087A (da)	1987-02-25
NO870759D0 (no)	1987-02-24
DK98087D0 (da)	1987-02-25
FI88509B (fi)	1993-02-15
NO870759L (no)	1987-02-24
JPS63500101A (ja)	1988-01-14
FI870808A0 (fi)	1987-02-25
ATE68001T1 (de)	1991-10-15
US4859370A (en)	1989-08-22
EP0227813A1 (en)	1987-07-08
DE3681786D1 (de)	1991-11-07
WO1987000175A1 (en)	1987-01-15
JPH0816117B2 (ja)	1996-02-21
USRE34136E (en)	1992-12-01
EP0227813B1 (en)	1991-10-02

Publication	Publication Date	Title
FI870808A (fi)	1987-02-25	9-alfa, 11-beta-substituerade och 11-beta-substituerade estraner.
ES511433A0 (es)	1983-02-16	"procedimiento de preparacion de productos utiles particularmente en medicamentos utilizables para el tratamiento de melanomas".
ES2036737T3 (es)	1993-06-01	Procedimiento para la obtencion de mezclas farmaceuticas.
IT8219730A0 (it)	1982-02-18	Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia.
NL300045I2 (nl)	2002-01-02	Fluorcytidine-derivaten, de bereiding daarvan en geneesmiddelen die deze derivaten bevatten.
DE68910892D1 (de)	1994-01-05	Arzneimittel zur Verhütung von sexuell übertragbaren Krankheiten.
DE3679908D1 (de)	1991-07-25	Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
GR3005768T3 (fi)	1993-06-07
ES551081A0 (es)	1987-05-16	Metodo de preparacion de tabletas por compresion directa.
NL8601838A (nl)	1987-02-16	Distamycinederivaten, werkwijze voor de bereiding ervan, alsmede farmaceutische preparaten, die deze derivaten bevatten.
MX9102580A (es)	1992-06-01	Nuevas benzodiacepinonas, procedimiento para su preparacion y composicion farmaceutica que las contiene.
DE3477469D1 (en)	1989-05-03	Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof
ES2018092B3 (es)	1991-03-16	Sabana quirurgica y metodo para su fabricacion.
IT1240302B (it)	1993-12-07	Struttura di scocca,procedimento ed apparecchio per la sua produzione.
NL930078I2 (nl)	1993-11-16	Aminederivaten, werkwijze voor de bereiding daarvan en farmaceutische preparaten die deze bevatten.
MX14310A (es)	1993-10-01	Procedimiento para la preparacion de nuevos agentes antiarritmicos, producto obtenido y preparacion farmaceutica que lo incluye.
ES542817A0 (es)	1985-12-16	Procedimiento para preparar gluconato de 2-amino-3-etoxicar-bonil-amino-6-(p-fluoro-bencilamino)-piridina
IT8847871A0 (it)	1988-04-20	Ne e loro impiego come medicamenti derivati peptidici,loro preparazio-
MX9201848A (es)	1992-10-01	Antiserotoninas, procedimiento para su preparacion y medicamentos que las contienen.
ES530383A0 (es)	1985-10-01	Procedimiento para coadyuvar vacunas exentas de aceite.
KR900007816A (ko)	1990-06-02	사이클로프로필-치환된 아졸릴메틸카비놀, 이의 제조방법 및 약제로서의 이의 용도
DK424987A (da)	1988-02-19	Farmaceutisk praeparat til indgivelse gennem huden og fremgangsmaade til dets fremstilling
NL186860C (nl)	1991-03-18	N,n'-bis-(3-picolyl)-4-methoxy-isoftalamidemonohydraat, werkwijze voor de bereiding daarvan en farmaceutische preparaten, die dit bevatten.
ES515141A1 (es)	1983-05-01	Procedimiento para la obtencion de frasquitos tubulares y ampollas.
IT8321732A0 (it)	1983-06-22	Apparecchio di diluizione, specialmente per la fabbricazione di medicinali omeopatici.

Legal Events

Date	Code	Title	Description
1993-01-18	BB	Publication of examined application
1998-06-24	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: SRI INTERNATIONAL