FI863311A0 - PHARMACEUTICAL COMPOSITION INNEHAOLLANDE ACYLERADE FOSFOLIPIDER. - Google Patents
PHARMACEUTICAL COMPOSITION INNEHAOLLANDE ACYLERADE FOSFOLIPIDER.Info
- Publication number
- FI863311A0 FI863311A0 FI863311A FI863311A FI863311A0 FI 863311 A0 FI863311 A0 FI 863311A0 FI 863311 A FI863311 A FI 863311A FI 863311 A FI863311 A FI 863311A FI 863311 A0 FI863311 A0 FI 863311A0
- Authority
- FI
- Finland
- Prior art keywords
- appropriate
- pharmaceutically acceptable
- fosfolipider
- acylerade
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000008105 phosphatidylcholines Chemical class 0.000 abstract 1
- 150000003905 phosphatidylinositols Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The compositions consist of a) a phospholipid of the formula <IMAGE> in which m is two or three, R1 and R2 are, independently of one another, alkyl, alkenyl or acyl each with 10 to 20 C atoms, and X is a direct bond, C1-C4-alkylene, C2-C4-alkenylene or C1-C4-alkylene or C2-C4-alkenylene substituted by hydroxyl, or a pharmaceutically acceptable salt thereof, b) a phospholipid of the formula <IMAGE> in which R3 and R4 are the acyl group of a saturated or unsaturated carboxylic acid with 10 to 20 C atoms and 1 to 2 double bonds, c) a compound or a mixture of compounds with pharmacological properties and, where appropriate, d) a lipid from the group comprising phosphatidylcholines, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, cardiolipin and cholesterol and, where appropriate, a pharmaceutically acceptable carrier solution which is buffered to pH 7.0 to 7.8 and, where appropriate, pharmaceutically acceptable auxiliaries. The compositions can be used in the form of liposomes as administration systems, for example for cancer chemotherapy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76662585A | 1985-08-19 | 1985-08-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI863311A0 true FI863311A0 (en) | 1986-08-15 |
| FI863311A FI863311A (en) | 1987-02-20 |
Family
ID=25077017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI863311A FI863311A (en) | 1985-08-19 | 1986-08-15 | PHARMACEUTICAL COMPOSITION INNEHAOLLANDE ACYLERADE FOSFOLIPIDER. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0213523B1 (en) |
| JP (1) | JPS6296431A (en) |
| KR (1) | KR870001838A (en) |
| AT (1) | ATE59002T1 (en) |
| AU (1) | AU591162B2 (en) |
| CA (1) | CA1273575A (en) |
| DD (1) | DD248736A5 (en) |
| DE (1) | DE3676133D1 (en) |
| DK (1) | DK165314C (en) |
| ES (1) | ES2001099A6 (en) |
| FI (1) | FI863311A (en) |
| GR (1) | GR862144B (en) |
| HU (1) | HU206045B (en) |
| NO (1) | NO171886C (en) |
| NZ (1) | NZ217239A (en) |
| PH (1) | PH26160A (en) |
| PT (1) | PT83204B (en) |
| ZA (1) | ZA866200B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0256989A1 (en) * | 1986-08-18 | 1988-02-24 | Board Of Regents, The University Of Texas System | Pharmaceutical administration systems containing chemotactic peptides |
| DK86988A (en) * | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | LIPOSOM PREPARATION AND APPLICATION THEREOF |
| WO1991014423A1 (en) * | 1990-03-20 | 1991-10-03 | Otsuka Pharmaceutical Co., Ltd. | Liposome preparation |
| DE69429511T2 (en) * | 1993-05-21 | 2002-05-16 | The Liposome Co., Inc. | REDUCTION OF PHYSIOLOGICAL COUNTER REACTIONS INDUCED BY LIPOSOME |
| JPH10507450A (en) * | 1994-10-14 | 1998-07-21 | ザ リポソーム カンパニー、インコーポレーテッド | Ether lipid liposomes and their therapeutic use |
| US8038984B2 (en) | 1998-06-20 | 2011-10-18 | Washington University | Membrane-permeant peptide complexes for treatment of sepsis |
| US7306784B2 (en) | 1998-06-20 | 2007-12-11 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US6589503B1 (en) | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US7803351B2 (en) | 2004-08-20 | 2010-09-28 | Washington University | Blood brain barrier permeation peptides |
| JP2006248978A (en) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | New liposome preparation |
| EP3676296A1 (en) | 2017-08-30 | 2020-07-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-mesothelin radiolabelled single domain antibodies suitable for the imaging and treatment of cancers |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3218027A1 (en) * | 1982-05-13 | 1983-11-17 | A. Nattermann & Cie GmbH, 5000 Köln | PHOSPHOLIPID SOLUTIONS |
-
1986
- 1986-07-18 PH PH34151A patent/PH26160A/en unknown
- 1986-08-14 PT PT83204A patent/PT83204B/en not_active IP Right Cessation
- 1986-08-15 FI FI863311A patent/FI863311A/en not_active Application Discontinuation
- 1986-08-15 CA CA000516015A patent/CA1273575A/en not_active Expired - Lifetime
- 1986-08-18 AT AT86111368T patent/ATE59002T1/en not_active IP Right Cessation
- 1986-08-18 NZ NZ217239A patent/NZ217239A/en unknown
- 1986-08-18 JP JP61191795A patent/JPS6296431A/en active Pending
- 1986-08-18 GR GR862144A patent/GR862144B/en unknown
- 1986-08-18 HU HU863618A patent/HU206045B/en not_active IP Right Cessation
- 1986-08-18 EP EP86111368A patent/EP0213523B1/en not_active Expired - Lifetime
- 1986-08-18 KR KR1019860006783A patent/KR870001838A/en not_active Application Discontinuation
- 1986-08-18 NO NO863315A patent/NO171886C/en unknown
- 1986-08-18 ES ES8601163A patent/ES2001099A6/en not_active Expired
- 1986-08-18 DK DK392786A patent/DK165314C/en not_active IP Right Cessation
- 1986-08-18 DD DD86293707A patent/DD248736A5/en not_active IP Right Cessation
- 1986-08-18 AU AU61556/86A patent/AU591162B2/en not_active Ceased
- 1986-08-18 DE DE8686111368T patent/DE3676133D1/en not_active Expired - Lifetime
- 1986-08-18 ZA ZA866200A patent/ZA866200B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO171886B (en) | 1993-02-08 |
| DD248736A5 (en) | 1987-08-19 |
| JPS6296431A (en) | 1987-05-02 |
| EP0213523A3 (en) | 1987-10-14 |
| AU591162B2 (en) | 1989-11-30 |
| NZ217239A (en) | 1989-09-27 |
| AU6155686A (en) | 1987-02-26 |
| EP0213523A2 (en) | 1987-03-11 |
| PH26160A (en) | 1992-03-18 |
| PT83204A (en) | 1986-09-01 |
| HUT41634A (en) | 1987-05-28 |
| DK392786A (en) | 1987-02-20 |
| ATE59002T1 (en) | 1990-12-15 |
| NO863315D0 (en) | 1986-08-18 |
| DK392786D0 (en) | 1986-08-18 |
| PT83204B (en) | 1989-03-30 |
| CA1273575A (en) | 1990-09-04 |
| FI863311A (en) | 1987-02-20 |
| HU206045B (en) | 1992-08-28 |
| DK165314C (en) | 1993-03-29 |
| ES2001099A6 (en) | 1988-04-16 |
| ZA866200B (en) | 1987-03-25 |
| DK165314B (en) | 1992-11-09 |
| KR870001838A (en) | 1987-03-28 |
| EP0213523B1 (en) | 1990-12-12 |
| NO863315L (en) | 1987-02-20 |
| GR862144B (en) | 1986-12-23 |
| DE3676133D1 (en) | 1991-01-24 |
| NO171886C (en) | 1993-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| FD | Application lapsed |
Owner name: THE BOARD OF REGENTS UNIVERSITY OF TEXAS |