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FI854768A - Bensoxazol- och bensotiazolaminderivat. - Google Patents

Bensoxazol- och bensotiazolaminderivat. Download PDF

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Publication number
FI854768A
FI854768A FI854768A FI854768A FI854768A FI 854768 A FI854768 A FI 854768A FI 854768 A FI854768 A FI 854768A FI 854768 A FI854768 A FI 854768A FI 854768 A FI854768 A FI 854768A
Authority
FI
Finland
Prior art keywords
chem
compounds
formula
bensoxazol
bensotiazolaminderivat
Prior art date
Application number
FI854768A
Other languages
English (en)
Other versions
FI82046B (fi
FI82046C (fi
FI854768A0 (fi
Inventor
Raymond Antoine Stokbroekx
Marcel Gerebernus Maria Luyckx
Frans Eduard Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI854768A0 publication Critical patent/FI854768A0/fi
Publication of FI854768A publication Critical patent/FI854768A/fi
Publication of FI82046B publication Critical patent/FI82046B/fi
Application granted granted Critical
Publication of FI82046C publication Critical patent/FI82046C/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Paints Or Removers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
FI854768A 1984-12-03 1985-12-02 Foerfarande foer framstaellning av terapeutiskt anvaendbara bensoxazol-, bensotiazol- och tiazolopyridinaminer. FI82046C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67741284A 1984-12-03 1984-12-03
US67741284 1984-12-03

Publications (4)

Publication Number Publication Date
FI854768A0 FI854768A0 (fi) 1985-12-02
FI854768A true FI854768A (fi) 1986-06-04
FI82046B FI82046B (fi) 1990-09-28
FI82046C FI82046C (fi) 1991-01-10

Family

ID=24718604

Family Applications (1)

Application Number Title Priority Date Filing Date
FI854768A FI82046C (fi) 1984-12-03 1985-12-02 Foerfarande foer framstaellning av terapeutiskt anvaendbara bensoxazol-, bensotiazol- och tiazolopyridinaminer.

Country Status (27)

Country Link
EP (1) EP0184257B1 (fi)
JP (1) JPH0759578B2 (fi)
KR (1) KR870001512B1 (fi)
CN (1) CN1014790B (fi)
AT (1) ATE54916T1 (fi)
AU (1) AU582601B2 (fi)
BG (1) BG60431B2 (fi)
CA (1) CA1260474A (fi)
CY (1) CY1690A (fi)
DE (1) DE3578885D1 (fi)
DK (1) DK165370C (fi)
DZ (1) DZ863A1 (fi)
ES (1) ES8606306A1 (fi)
FI (1) FI82046C (fi)
GR (1) GR852830B (fi)
HK (1) HK49593A (fi)
HU (1) HU196068B (fi)
IE (1) IE58807B1 (fi)
IL (1) IL77197A (fi)
MA (1) MA20582A1 (fi)
NO (1) NO160076C (fi)
NZ (1) NZ214320A (fi)
PH (1) PH26458A (fi)
PT (1) PT81586B (fi)
SU (1) SU1428203A3 (fi)
ZA (1) ZA859224B (fi)
ZW (1) ZW21685A1 (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB2225574B (en) * 1987-12-24 1991-04-24 Wyeth John & Brother Ltd Heterocyclic compounds
IE63474B1 (en) * 1987-12-24 1995-04-19 Wyeth John & Brother Ltd Heterocyclic compounds
JPH0393762A (ja) * 1989-09-04 1991-04-18 Wako Pure Chem Ind Ltd 4‐ハロゲノ‐2‐アルコキシイミノ‐3‐オキソ脂肪酸の製造方法
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (fi) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2725989B1 (fr) * 1994-10-20 1997-01-10 Pf Medicament Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
CZ155897A3 (en) * 1994-11-24 1997-10-15 Janssen Pharmaceutica Nv Intravenous solutions of lubezol
FR2737207B1 (fr) * 1995-07-26 1997-10-17 Pf Medicament Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique
CA2228054A1 (en) * 1995-10-25 1997-05-01 Janssen Pharmaceutica N.V. Lubeluzole n-oxide
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
FR2753970B1 (fr) * 1996-10-01 1998-10-30 Synthelabo Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
ES2317510T3 (es) * 2005-03-09 2009-04-16 F. Hoffmann-La Roche Ag Derivados de benzotiazol, tiazolopiridina, benzooxazol y oxazolopiridina.
BRPI0615449A2 (pt) * 2005-09-02 2011-05-17 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método de tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de sst do subtipo 5 e uso desses compostos
AU2008249329C1 (en) 2007-04-27 2013-07-04 Daiichi Sankyo Company Limited Nitrogenated aromatic 6-membered ring derivative, and pharmaceutical agent comprising the same
FR3001151B1 (fr) 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
CN107573301B (zh) * 2017-11-08 2020-08-11 江苏长青农化股份有限公司 一种三环唑中间体的制备方法
CN114349745B (zh) * 2022-01-14 2023-12-08 黑龙江中医药大学 一种用于治疗心肌缺血的药物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE831249C (de) * 1948-02-09 1952-02-11 Ciba A G Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline
GB1234058A (fi) * 1968-10-21 1971-06-03
DE2545645C2 (de) * 1975-10-11 1983-04-14 Bayer Ag, 5090 Leverkusen Thiazolinylamino-piperidin-Derivate
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
BG60431B2 (bg) 1995-03-31
CN1014790B (zh) 1991-11-20
ES8606306A1 (es) 1986-04-16
HK49593A (en) 1993-05-27
NO160076C (no) 1989-03-08
EP0184257A1 (en) 1986-06-11
JPH0759578B2 (ja) 1995-06-28
SU1428203A3 (ru) 1988-09-30
PH26458A (en) 1992-07-27
NZ214320A (en) 1988-03-30
CY1690A (en) 1994-01-14
HUT40668A (en) 1987-01-28
AU582601B2 (en) 1989-04-06
MA20582A1 (fr) 1986-07-01
KR860004894A (ko) 1986-07-14
PT81586B (pt) 1988-01-22
NO160076B (no) 1988-11-28
CN85108556A (zh) 1986-07-30
DK165370C (da) 1993-04-05
GR852830B (fi) 1986-03-27
ATE54916T1 (de) 1990-08-15
AU5057485A (en) 1986-07-17
DK165370B (da) 1992-11-16
IL77197A (en) 1991-07-18
FI82046B (fi) 1990-09-28
DK558185A (da) 1986-06-04
ES549542A0 (es) 1986-04-16
PT81586A (en) 1986-01-01
EP0184257B1 (en) 1990-07-25
ZW21685A1 (en) 1987-06-17
JPS61137884A (ja) 1986-06-25
DE3578885D1 (de) 1990-08-30
IE58807B1 (en) 1993-11-17
ZA859224B (en) 1987-07-29
DK558185D0 (da) 1985-12-02
HU196068B (en) 1988-09-28
IE853023L (en) 1986-06-03
DZ863A1 (fr) 2004-09-13
NO854837L (no) 1986-06-04
CA1260474A (en) 1989-09-26
KR870001512B1 (ko) 1987-08-20
FI82046C (fi) 1991-01-10
FI854768A0 (fi) 1985-12-02

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Legal Events

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MM Patent lapsed

Owner name: JANSSEN PHARMACEUTICA N.V.