[go: up one dir, main page]

FI854747L - Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. - Google Patents

Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. Download PDF

Info

Publication number
FI854747L
FI854747L FI854747A FI854747A FI854747L FI 854747 L FI854747 L FI 854747L FI 854747 A FI854747 A FI 854747A FI 854747 A FI854747 A FI 854747A FI 854747 L FI854747 L FI 854747L
Authority
FI
Finland
Prior art keywords
inhiberande
dipeptider
renin
dem
deras framstaellning
Prior art date
Application number
FI854747A
Other languages
English (en)
Other versions
FI854747A0 (fi
Inventor
Yasuhiro Morisawa
Yuichiro Yabe
Mitsuru Kataoka
Yasuteru Iijima
Tatsuo Kokubu
Kunio Hiwada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI854747A0 publication Critical patent/FI854747A0/fi
Publication of FI854747L publication Critical patent/FI854747L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI854747A 1984-11-30 1985-11-29 Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. FI854747L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25287884 1984-11-30
JP26803584 1984-12-19
JP1517785 1985-01-29

Publications (2)

Publication Number Publication Date
FI854747A0 FI854747A0 (fi) 1985-11-29
FI854747L true FI854747L (fi) 1986-05-31

Family

ID=27280905

Family Applications (1)

Application Number Title Priority Date Filing Date
FI854747A FI854747L (fi) 1984-11-30 1985-11-29 Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem.

Country Status (8)

Country Link
EP (1) EP0186977A3 (fi)
KR (1) KR910001721B1 (fi)
DK (1) DK554685A (fi)
ES (1) ES8800958A1 (fi)
FI (1) FI854747L (fi)
HU (1) HUT39463A (fi)
NO (1) NO854825L (fi)
SU (1) SU1676454A3 (fi)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
KR870005013A (ko) * 1985-11-29 1987-06-04 가와무라 요시부미 레닌-억제 올리고펩티드, 그의 제조방법 및 용도
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3610593A1 (de) * 1986-03-29 1987-10-01 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
US4735933A (en) * 1986-12-15 1988-04-05 Warner-Lambert Company Renin inhibitors III
US4895834A (en) * 1986-12-15 1990-01-23 Warner-Lambert Company Renin inhibitors III
DE3789101T2 (de) * 1986-12-19 1994-07-21 Sankyo Co Renin inhibierende Oligopeptide, ihre Präparation und ihre Anwendung.
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions
US5024994A (en) * 1986-12-23 1991-06-18 Warner-Lambert Company Renin inhibitors IV
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II
KR890701619A (ko) * 1987-10-26 1989-12-22 크리스틴 에이.트러트웨인 레닌 억제제, 그의 제조 방법, 그 사용 방법 및 이들을 함유한 조성물
US5063207A (en) * 1987-10-26 1991-11-05 Warner-Lambert Company Renin inhibitors, method for using them, and compositions containing them
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
US5036054A (en) * 1988-02-11 1991-07-30 Warner-Lambert Company Renin inhibitors containing alpha-heteroatom amino acids
CA2004846A1 (en) * 1988-12-19 1990-06-19 Yutaka Koike N-substituted acylamino acid compounds, process for their production and their use
US5106835A (en) * 1988-12-27 1992-04-21 American Cyanamid Company Renin inhibitors
ES2077021T3 (es) * 1989-02-16 1995-11-16 Sankyo Co Peptidos que tienen actividad inhibidora de renina, su preparacion y uso.
CA2100171A1 (en) * 1991-01-31 1992-08-01 Kazumi Shiosaki Endothelin converting enzyme inhibitors
US5227401A (en) * 1991-10-29 1993-07-13 G. D. Searle & Co. Ethynyl alanine amino diol compounds for treatment of hypertension
US5223535A (en) * 1991-10-29 1993-06-29 G. D. Searle & Co. Propargyl glycine amino propargyl diol compounds for treatment of hypertension
US5330996A (en) * 1991-10-29 1994-07-19 G. D. Searle & Co. Amino acyl amino propargyl diol compounds for treatment of hypertension
EP0539976A1 (en) * 1991-10-29 1993-05-05 G.D. Searle & Co. Ethynyl-alanine-amino-diol compounds for treatment of hypertension
US5246969A (en) * 1992-07-20 1993-09-21 G. D. Searle & Co. Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5317039A (en) * 1992-07-20 1994-05-31 G. D. Searle & Co. Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5268391A (en) * 1992-07-20 1993-12-07 C. D. Searle & Co. Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5314920A (en) * 1992-07-20 1994-05-24 G. D. Searle & Co. Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension
US5252591A (en) * 1992-08-14 1993-10-12 G. D. Searle & Company Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5298505A (en) * 1992-08-14 1994-03-29 G. D. Searle & Co. Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5312838A (en) * 1992-09-21 1994-05-17 G. D. Searle & Co. β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5414018A (en) * 1993-09-24 1995-05-09 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension
US5416119A (en) * 1993-10-25 1995-05-16 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension
US5432201A (en) * 1993-11-22 1995-07-11 G. D. Searle & Co. Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension
US5508466A (en) * 1994-04-13 1996-04-16 G.D. Searle & Co. Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent
US5780494A (en) * 1994-11-14 1998-07-14 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension
MX346043B (es) * 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070458A (en) * 1974-02-28 1978-01-24 Sanraku-Ocean Co., Ltd. Novel physiologically active peptide and its n-acyl derivatives and processes for producing thereof
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
JPS61152967A (ja) * 1984-12-26 1986-07-11 Toyota Motor Corp 内燃機関の着火時期センサ

Also Published As

Publication number Publication date
EP0186977A2 (en) 1986-07-09
FI854747A0 (fi) 1985-11-29
KR860004080A (ko) 1986-06-16
ES8800958A1 (es) 1987-12-01
KR910001721B1 (ko) 1991-03-22
DK554685D0 (da) 1985-11-29
DK554685A (da) 1986-05-31
EP0186977A3 (en) 1987-09-16
ES549457A0 (es) 1987-12-01
HUT39463A (en) 1986-09-29
SU1676454A3 (ru) 1991-09-07
NO854825L (no) 1986-06-02

Similar Documents

Publication Publication Date Title
FI854747L (fi) Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem.
FI840655A (fi) Foerbaettrade nykleinsyrareagenser, foerfarande foer deras framstaellning och anvaendning av dessa.
FI852659L (fi) Foerstadier av 3-hydroximorfinaner, substituerade benzoatesterderivat, deras mellanprodukter och foerfaranden.
FI854363L (fi) Prefabricerade moduler och anvaendning av dem i byggnadsindustrin.
FI843929A0 (fi) Skivstruktur i flera skikt, foerfarande foer framstaellning av densamma och behaollare framstaellda daerav.
FI862591A0 (fi) Profilpelare foer fastspaenning av skivor, saerskilt glasskivor, foer utstaellningsvitriner, foersaeljningsbord marknadsloesare och motsvarande.
FI872106A0 (fi) Extrakt av nerium-arter, foerfarande foer framstaellning av dem och deras anvaendning.
FI853392A0 (fi) Kontinuerligt arbetande press foer pressande av spaonplattbanor, fiberplattbanor och motsvarande pressmaterialbanor.
FI853393A0 (fi) Kontinuerligt arbetande press foer pressande av spaonplattbanor, fiberplattbanor och motsvarande pressmaterialbanor.
FI843692A0 (fi) Azolderivat, foerfarande foer framstaellning av dem, kompositioner innehaollande dem och anvaendning av dem.
FI851547A0 (fi) Nagellackkompositioenr och anordning foer applicering av dem.
FI855201A0 (fi) Belagda fiskfoderpelletter och foerfarande foer framstaellning av dem.
FI855037L (fi) Foerfarande foer framstaellning av latexpolymerkompositioner, latexpolymerkompositioner och deras anvaendning.
FI862206L (fi) Anordning foer fasthaollning, akustisk taetning och vibrationsisolering av en elektroakustisk omvandlare.
FI852851A0 (fi) Naftylanaloger av mevalonlakton och derivat av dem, foerfaranden foer framstaellning av dem och deras anvaendning.
FI853224A0 (fi) Foerfarande och anordning foer framstaellning av haolplattor och motsvarande byggelement, foeretraedesvis av betong.
FI843813A0 (fi) Cyklisk process foer framstaellning av en alkaliloesning av cellulosakarbamat, foer utfaellning av karbamaten och foer aotervinning av kemikalierna.
FI853513L (fi) Foeroreningsavlaegsningsenhet foer verktyg foer avlaegsnande av radioaktiv, kemisk och biologisk foerorening fraon dessa.
FI875540L (fi) Polymerer innehaollande imidgrupper, framstaellda av steriskt foerhindrade diaminer, och foerfaranden foer framstaellning av dem.
FI863081A0 (fi) Foerfarande foer aostadkommande av en skyddad omgivning omkring en arbetszon, skyddshoelje foer utfoerande av foerfarandet och foerfarande foer foerpackning av skyddshoeljet.
FI852464A0 (fi) Foerfarande foer framstaellning av flerskiktkretskort en medelst detta foerfarande framstaelld, fastsatt skiktstruktur och anvaendning av denna skiktstruktur i detta framstaellningsfoerfarande.
FI844419A0 (fi) Foerfarande foer styrning av alkalisk cellulosakokning medelst en snabb analysator, vilken maeter oorganiska och organiska kokvaetskekomponenter.
FI850841A0 (fi) Korsfogsbalkar, fraesmaskin foer framstaellning av dessa och av dessa framstaellda byggnader.
FI843895L (fi) Foerfarande foer avlaegsnande av vatten fraon en fiberbana, speciellt fraon en pappers- eller kartongbana och en vaotpress i en pappersmaskin foer tillaempning av foerfarandet.
FI853912A0 (fi) Saett och anordning att initiera, oevervaka och avbryta foerbraenningen av braennbara gaser.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: SANKYO COMPANY LIMITED