FI83308B - Foerfarande foer framstaellning av terapeutiskt aktiva dihydropyridinderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva dihydropyridinderivat. Download PDFInfo
- Publication number
- FI83308B FI83308B FI851857A FI851857A FI83308B FI 83308 B FI83308 B FI 83308B FI 851857 A FI851857 A FI 851857A FI 851857 A FI851857 A FI 851857A FI 83308 B FI83308 B FI 83308B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compound
- sub
- methyl
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
1. Förfarande för framställning av ett terapeutiskt aktivt 1,4-dihydropyridinderivat med formeln (I)
5 HR R1OOC \X><C^COOR2 Y X CH.'^^N^^CH9-0-Y-0H -3 H 10 eller ett farmaceutiskt godtagbart sait därav, 1 vilken formel R är fenyl, som eventuellt är substltuerad med en eller tvä substituenter av gruppen halogen och trifluorme-tyl, R1 och R2 är oberoende av varandra Cj-C^-alkyl och Y är
15 -CH2CH(CH3)-, -CH2C(CH3)2- eller -(CH2)n-, väri n är 2, 3 eller 4, kännetecknat därav, att a) för framställning av en förening med formeln (I), väri Y är -(CH2)n, en förening med formeln
20. H R R 00C OK^COOR2 a jT (v) CHX CH_0 (CH0) .COOX H l l n-1 25 väri R, R1, R2 och n är ovan definierade och X är H eller Cj-C^alkyl, reduceras medelst ett reducerande medel, eller b) för framställning av en förening med formeln (I), väri Y är -(CH2)n-, ett oxazin med formeln 30 H R R1OOC ^XKX^COOR2 T l 11111 \ 35 0 28 83308 väri R, R1 och R2 är ovan definierade, reduceras medelst ett reducerande medel, eller c) för framställning av en förening med formeln (I), väri Y är -CH2CH(CH3)- eller -CH2C(CH3)2-, en förening 5 med formeln H R R OOCN>J^><r^COOR2 T ΪΓ <IV1 10 ch2och2coch3 omsätts antingen i) med ett reducerande medel, varvid en förening med formeln (I), väri Y är -CH2CH(CH3)-, bildas, eller 15 ii) med metyllitium, varvid en förening med formeln (I), väri Y är -CH2C(CH3)2-, bildas; och om sä önskas omvandlas den genom förfarandet a), b) eller c) erhällna föreningen med formeln (I) tili ett far-maceutiskt godtagbart sait. 20
2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att R är klorfenyl, 2,3-diklorfenyl eller 2-klor-3-trifluormetylfenyl.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att Y är -(CH2)2-, -(CH2)4-, 25 -CH2CH(CH3)- eller -CH2C(CH3)2-, R1 är metyl och R2 är etyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8412208 | 1984-05-12 | ||
| GB848412208A GB8412208D0 (en) | 1984-05-12 | 1984-05-12 | Quinolone inotropic agents |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI851857A0 FI851857A0 (fi) | 1985-05-10 |
| FI851857L FI851857L (fi) | 1985-11-13 |
| FI83308B true FI83308B (fi) | 1991-03-15 |
| FI83308C FI83308C (sv) | 1991-06-25 |
Family
ID=10560892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI851857A FI83308C (sv) | 1984-05-12 | 1985-05-10 | Förfarande för framställning av terapeutiskt aktiva dihydropyridinderi vat |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4654353A (sv) |
| EP (1) | EP0161917B1 (sv) |
| JP (1) | JPS60246368A (sv) |
| KR (1) | KR880000131B1 (sv) |
| AT (1) | ATE50988T1 (sv) |
| AU (1) | AU554257B2 (sv) |
| CA (1) | CA1278573C (sv) |
| DD (1) | DD235867A5 (sv) |
| DE (1) | DE3576499D1 (sv) |
| DK (1) | DK162982C (sv) |
| ES (2) | ES8609252A1 (sv) |
| FI (1) | FI83308C (sv) |
| GB (1) | GB8412208D0 (sv) |
| GR (1) | GR851130B (sv) |
| HU (1) | HU194172B (sv) |
| IE (1) | IE57751B1 (sv) |
| IL (1) | IL75165A (sv) |
| NO (1) | NO851886L (sv) |
| NZ (1) | NZ212033A (sv) |
| PH (1) | PH20931A (sv) |
| PL (1) | PL253328A1 (sv) |
| PT (1) | PT80427B (sv) |
| SU (1) | SU1417795A3 (sv) |
| YU (1) | YU78085A (sv) |
| ZA (1) | ZA853543B (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930011486B1 (ko) * | 1985-08-06 | 1993-12-08 | 베링거 만하임 이탈리아 에스.피.에이. | 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘 |
| GB8526411D0 (en) * | 1985-10-25 | 1985-11-27 | Pfizer Ltd | Dihydropyridines |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
| US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
| GB8709447D0 (en) * | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Dihydropyridines |
| US6541479B1 (en) * | 1997-12-02 | 2003-04-01 | Massachusetts College Of Pharmacy | Calcium channel blockers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
| CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| EP0100189B1 (en) * | 1982-07-22 | 1986-05-28 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
| DE3311005A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3567460D1 (en) * | 1984-06-07 | 1989-02-16 | Pfizer Ltd | Dihydropyridines |
-
1984
- 1984-05-12 GB GB848412208A patent/GB8412208D0/en active Pending
-
1985
- 1985-04-26 US US06/727,704 patent/US4654353A/en not_active Expired - Lifetime
- 1985-05-07 PH PH32235A patent/PH20931A/en unknown
- 1985-05-09 JP JP60098876A patent/JPS60246368A/ja active Granted
- 1985-05-09 GR GR851130A patent/GR851130B/el unknown
- 1985-05-09 PT PT80427A patent/PT80427B/pt not_active IP Right Cessation
- 1985-05-10 IL IL75165A patent/IL75165A/xx unknown
- 1985-05-10 AT AT85303304T patent/ATE50988T1/de not_active IP Right Cessation
- 1985-05-10 ES ES543033A patent/ES8609252A1/es not_active Expired
- 1985-05-10 NO NO851886A patent/NO851886L/no unknown
- 1985-05-10 ZA ZA853543A patent/ZA853543B/xx unknown
- 1985-05-10 PL PL25332885A patent/PL253328A1/xx unknown
- 1985-05-10 IE IE1168/85A patent/IE57751B1/en not_active IP Right Cessation
- 1985-05-10 DE DE8585303304T patent/DE3576499D1/de not_active Expired - Lifetime
- 1985-05-10 YU YU00780/85A patent/YU78085A/xx unknown
- 1985-05-10 EP EP85303304A patent/EP0161917B1/en not_active Expired - Lifetime
- 1985-05-10 DD DD85276212A patent/DD235867A5/de unknown
- 1985-05-10 FI FI851857A patent/FI83308C/sv not_active IP Right Cessation
- 1985-05-10 CA CA000481320A patent/CA1278573C/en not_active Expired - Lifetime
- 1985-05-10 HU HU851778A patent/HU194172B/hu unknown
- 1985-05-10 AU AU42269/85A patent/AU554257B2/en not_active Ceased
- 1985-05-10 DK DK207885A patent/DK162982C/da active
- 1985-05-10 NZ NZ212033A patent/NZ212033A/en unknown
- 1985-05-11 SU SU853901005A patent/SU1417795A3/ru active
- 1985-05-11 KR KR1019850003214A patent/KR880000131B1/ko not_active IP Right Cessation
-
1986
- 1986-01-16 ES ES550965A patent/ES8703429A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: PFIZER CORPORATION |