FI833047A - Mellanprodukter foer framstaellning av omeprazol - Google Patents

Mellanprodukter foer framstaellning av omeprazol Download PDF

Info

Publication number: FI833047A
Authority: FI; Finland
Prior art keywords: omeprazol; foer framstaellning; mellanprodukter; mellanprodukter foer; sub
Prior art date: 1982-08-26

Application number

FI833047A

Other languages

English (en)

Other versions

FI79701B (fi

FI833047A0 (fi

FI79701C (fi

Inventor

Arne Elof Braendstroem

Bo Robert Lamm

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-26

Filing date

1983-08-25

Publication date

1984-02-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20347627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI833047(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-08-25 Application filed by Haessle Ab filed Critical Haessle Ab

1983-08-25 Publication of FI833047A0 publication Critical patent/FI833047A0/fi

1984-02-27 Publication of FI833047A publication Critical patent/FI833047A/fi

1989-10-31 Publication of FI79701B publication Critical patent/FI79701B/fi

1990-02-12 Application granted granted Critical

1990-02-12 Publication of FI79701C publication Critical patent/FI79701C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Compounds Of Unknown Constitution (AREA)

FI833047A 1982-08-26 1983-08-25 Mellanprodukter foer framstaellning av omeprazol. FI79701C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8204879A SE8204879D0 (sv)	1982-08-26	1982-08-26	Novel chemical intermediates
SE8204879		1982-08-26

Publications (4)

Publication Number	Publication Date
FI833047A0 FI833047A0 (fi)	1983-08-25
FI833047A true FI833047A (fi)	1984-02-27
FI79701B FI79701B (fi)	1989-10-31
FI79701C FI79701C (fi)	1990-02-12

Family

ID=20347627

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI833047A FI79701C (fi)	1982-08-26	1983-08-25	Mellanprodukter foer framstaellning av omeprazol.

Country Status (28)

Country	Link
US (2)	US4544750A (fi)
EP (1)	EP0103553B1 (fi)
JP (1)	JPS5959662A (fi)
KR (1)	KR880000091B1 (fi)
AT (1)	ATE40884T1 (fi)
AU (1)	AU560028B2 (fi)
CA (1)	CA1234118A (fi)
CY (1)	CY1328A (fi)
DD (1)	DD233126A5 (fi)
DE (2)	DE103553T1 (fi)
DK (1)	DK381583A (fi)
ES (1)	ES8404993A1 (fi)
FI (1)	FI79701C (fi)
GB (1)	GB2126226B (fi)
GR (1)	GR79374B (fi)
HK (1)	HK19486A (fi)
HU (1)	HU189738B (fi)
IE (1)	IE55865B1 (fi)
IL (1)	IL69175A (fi)
IS (1)	IS1438B6 (fi)
MY (1)	MY8600503A (fi)
NO (1)	NO164093C (fi)
NZ (1)	NZ204959A (fi)
OA (1)	OA07498A (fi)
PH (1)	PH17786A (fi)
PT (1)	PT77249B (fi)
SE (1)	SE8204879D0 (fi)
ZA (1)	ZA835143B (fi)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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SE8404065D0 (sv) *	1984-08-10	1984-08-10	Haessle Ab	Novel biologically active compounds
SE8504409D0 (sv) *	1985-09-24	1985-09-24	Haessle Ab	Novel chemical intermediates
US5221316A (en) *	1986-04-17	1993-06-22	Imperial Chemical Industries Plc	Fungicides
EP0243012B1 (en) *	1986-04-17	1993-01-13	Imperial Chemical Industries Plc	Pyridyl-acrylic acid ester derivatives, process for their preparation and their use as fungicides
US4920230A (en) *	1987-06-29	1990-04-24	Takeda Chemical Industries, Ltd.	Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group
AT391693B (de) *	1988-11-15	1990-11-12	Cl Pharma	Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
US4965269A (en) *	1989-12-20	1990-10-23	Ab Hassle	Therapeutically active chloro substituted benzimidazoles
ES2026761A6 (es) *	1990-10-31	1992-05-01	Genesis Para La Investigacion	Procedimiento de obtencion del omeprazol.
ES2036948B1 (es) *	1991-11-21	1994-09-01	Genesis Para La Investigacion	Procedimiento de obtencion de compuestos derivados de piridina.
ES2060541B1 (es) *	1993-02-26	1995-11-16	Vinas Lab	Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
SE9301830D0 (sv) *	1993-05-28	1993-05-28	Ab Astra	New compounds
ES2097089B1 (es) *	1995-02-01	1997-12-16	Esteve Quimica Sa	Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
US6699885B2 (en) *	1996-01-04	2004-03-02	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en)	1996-01-04	2003-11-11	Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6437139B1 (en)	1997-05-06	2002-08-20	Pdi-Research Laboratories, Inc.	Synthesis of pharmaceutically useful pyridine derivatives
CA2204580A1 (en) *	1997-05-06	1998-11-06	Michel Zoghbi	Synthesis of pharmaceutically useful pyridine derivatives
GB9717849D0 (en) *	1997-08-23	1997-10-29	Seal Sands Chemicals Limited	Preparation of pyridene derivatives
US6174548B1 (en)	1998-08-28	2001-01-16	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6096340A (en) *	1997-11-14	2000-08-01	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
AU1656699A (en) *	1997-12-24	1999-07-19	Pdi-Research Laboratories, Inc.	Synthesis of pharmaceutically useful pyridine derivatives
US6350876B2 (en)	1998-01-26	2002-02-26	Kuraray Co., Ltd.	4-chloro-3,5-dimethyl-2-sulfonyl pyridines
US6197962B1 (en)	1998-01-26	2001-03-06	Kuraray Co., Ltd.	Method for producing 2-sulfonylpyridine derivatives and method for producing 2-{[(2-pyridyl)methyl]thio}-1H-benzimidazole derivatives
US6303787B1 (en)	1998-05-27	2001-10-16	Natco Pharma Limited	Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
WO2000000474A1 (en) *	1998-06-26	2000-01-06	Russinsky Limited	Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds
US6733778B1 (en)	1999-08-27	2004-05-11	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6353005B1 (en)	1999-03-02	2002-03-05	Sepracor, Inc.	Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6362202B1 (en)	1999-03-02	2002-03-26	Sepracor Inc.	Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6555139B2 (en)	1999-06-28	2003-04-29	Wockhardt Europe Limited	Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en)	1999-06-30	2001-06-12	Wockhardt Europe Limited	Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6262086B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Pharmaceutical unit dosage form
US6312723B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Pharmaceutical unit dosage form
US6780880B1 (en)	1999-08-26	2004-08-24	Robert R. Whittle	FT-Raman spectroscopic measurement
US6369087B1 (en)	1999-08-26	2002-04-09	Robert R. Whittle	Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en)	1999-08-26	2001-12-04	Robert R. Whittle	Dry blend pharmaceutical unit dosage form
US6312712B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Method of improving bioavailability
US6316020B1 (en)	1999-08-26	2001-11-13	Robert R. Whittle	Pharmaceutical formulations
US6268385B1 (en)	1999-08-26	2001-07-31	Robert R. Whittle	Dry blend pharmaceutical formulations
US6262085B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
GB9921578D0 (en) *	1999-09-13	1999-11-17	Cipla Limited	Omeprazole synthesis
ES2171116B1 (es) *	2000-04-14	2003-08-01	Esteve Quimica Sa	Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
AU2000258410A1 (en) *	2000-07-28	2003-12-02	Herbex, Produtos Quimicos, Sa	New method for the preparation of the anti-ulcer compounds omeprazole, lansoprazole and pantoprazole
CZ304524B6 (cs)	2001-05-11	2014-06-18	Tibotec Pharmaceuticals Ltd.	Derivát 2-aminobenzoxazolsulfonamidu, farmaceutická kompozice s jeho obsahem a léčivo pro léčení infekce retroviry
JP2005521662A (ja) *	2002-01-25	2005-07-21	サンタラスインコーポレイティッド	プロトンポンプ阻害剤の経粘膜送達
FR2848555B1 (fr)	2002-12-16	2006-07-28	Negma Gild	Enantiomere(-)du tenatoprazole et son application en therapeutique
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en)	2004-05-25	2014-08-26	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN100376574C (zh) *	2006-06-14	2008-03-26	浙江大学	泰妥拉唑的制备方法
WO2008092939A2 (en)	2007-01-31	2008-08-07	Krka, Tovarna Zdravil, D.D., Novo Mesto	Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation
CN101648912B (zh) *	2009-09-14	2012-07-04	南京第一农药集团有限公司	一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN101648907B (zh) *	2009-09-14	2011-08-03	南京第一农药集团有限公司	2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN102603620B (zh) *	2012-01-13	2014-10-29	江苏中邦制药有限公司	一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
JP2022548785A (ja)	2019-09-24	2022-11-21	プロラクタバイオサイエンス，インコーポレイテッド	炎症性疾患及び免疫疾患の治療のための組成物及び方法
CN112142653B (zh) *	2020-10-22	2022-02-11	成都百泉生物医药科技有限公司	奥美拉唑中间体的制备方法
CN113307773A (zh) *	2021-06-17	2021-08-27	上海毕得医药科技股份有限公司	6-溴-3-甲氧基-1-苯基-1h-吲唑及其合成方法和应用
CN114805193B (zh) *	2022-04-19	2023-06-20	南京红太阳医药研究院有限公司	一种奥美拉唑中间体的制备方法

Family Cites Families (6)

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US2735851A (en) *		1956-02-21		Alkanolpykroine-n-oxides
US2663711A (en) *	1951-12-08	1953-12-22	Du Pont	Process for the preparation of pyridine alcohols from pyridine n-oxides
GB1564502A (en) *	1975-07-31	1980-04-10	Smith Kline French Lab	Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
US4472409A (en) *	1981-11-05	1984-09-18	Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung	2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
ZA828136B (en) *	1981-11-05	1983-09-28	Byk Gulden Lomberg Chem Fab	Substituted benzimidazoles,a process for their preparation,their use,and medicaments containing them

1982
- 1982-08-26 SE SE8204879A patent/SE8204879D0/xx unknown
1983
- 1983-06-30 EP EP83850185A patent/EP0103553B1/en not_active Expired
- 1983-06-30 DE DE198383850185T patent/DE103553T1/de active Pending
- 1983-06-30 AT AT83850185T patent/ATE40884T1/de not_active IP Right Cessation
- 1983-06-30 DE DE8383850185T patent/DE3379222D1/de not_active Expired
- 1983-07-06 CA CA000431863A patent/CA1234118A/en not_active Expired
- 1983-07-06 IL IL69175A patent/IL69175A/xx not_active IP Right Cessation
- 1983-07-14 ZA ZA835143A patent/ZA835143B/xx unknown
- 1983-07-20 AU AU17101/83A patent/AU560028B2/en not_active Expired
- 1983-07-20 OA OA58065A patent/OA07498A/xx unknown
- 1983-07-20 NZ NZ204959A patent/NZ204959A/en unknown
- 1983-07-28 IE IE1787/83A patent/IE55865B1/en not_active IP Right Cessation
- 1983-08-02 NO NO832794A patent/NO164093C/no not_active IP Right Cessation
- 1983-08-08 PH PH29368A patent/PH17786A/en unknown
- 1983-08-18 DD DD83254056A patent/DD233126A5/de unknown
- 1983-08-19 DK DK381583A patent/DK381583A/da not_active Application Discontinuation
- 1983-08-24 ES ES525122A patent/ES8404993A1/es not_active Expired
- 1983-08-25 CY CY1328A patent/CY1328A/xx unknown
- 1983-08-25 HU HU832987A patent/HU189738B/hu unknown
- 1983-08-25 FI FI833047A patent/FI79701C/fi not_active IP Right Cessation
- 1983-08-25 GB GB08322866A patent/GB2126226B/en not_active Expired
- 1983-08-25 PT PT77249A patent/PT77249B/pt unknown
- 1983-08-25 JP JP58154250A patent/JPS5959662A/ja active Granted
- 1983-08-26 US US06/526,900 patent/US4544750A/en not_active Expired - Lifetime
- 1983-08-26 GR GR72304A patent/GR79374B/el unknown
- 1983-08-26 IS IS2845A patent/IS1438B6/is unknown
- 1983-08-26 KR KR1019830004003A patent/KR880000091B1/ko not_active IP Right Cessation
1985
- 1985-02-01 US US06/697,396 patent/US4620008A/en not_active Expired - Lifetime
1986
- 1986-03-20 HK HK194/86A patent/HK19486A/xx not_active IP Right Cessation
- 1986-12-30 MY MY503/86A patent/MY8600503A/xx unknown

Also Published As

Publication number	Publication date
IE831787L (en)	1984-02-26
ES525122A0 (es)	1984-05-16
CA1234118A (en)	1988-03-15
PT77249B (en)	1986-07-14
GR79374B (fi)	1984-10-22
IL69175A0 (en)	1983-11-30
OA07498A (en)	1985-03-31
HK19486A (en)	1986-03-27
PH17786A (en)	1984-12-13
EP0103553A1 (en)	1984-03-21
FI79701B (fi)	1989-10-31
SE8204879D0 (sv)	1982-08-26
US4620008A (en)	1986-10-28
HU189738B (en)	1986-07-28
IS2845A7 (is)	1984-02-27
ES8404993A1 (es)	1984-05-16
KR880000091B1 (ko)	1988-02-23
AU1710183A (en)	1984-03-01
EP0103553B1 (en)	1989-02-22
US4544750A (en)	1985-10-01
CY1328A (en)	1986-06-27
FI833047A0 (fi)	1983-08-25
GB2126226B (en)	1985-09-18
IE55865B1 (en)	1991-01-30
ZA835143B (en)	1984-04-25
IS1438B6 (is)	1990-09-25
NO164093B (no)	1990-05-21
FI79701C (fi)	1990-02-12
JPS6353987B2 (fi)	1988-10-26
NO164093C (no)	1990-08-29
DK381583A (da)	1984-02-27
NO832794L (no)	1984-02-27
IL69175A (en)	1987-01-30
PT77249A (en)	1983-09-01
DD233126A5 (de)	1986-02-19
DK381583D0 (da)	1983-08-19
GB8322866D0 (en)	1983-09-28
GB2126226A (en)	1984-03-21
DE3379222D1 (en)	1989-03-30
ATE40884T1 (de)	1989-03-15
MY8600503A (en)	1986-12-31
JPS5959662A (ja)	1984-04-05
AU560028B2 (en)	1987-03-26
KR840005718A (ko)	1984-11-15
DE103553T1 (de)	1984-09-27
NZ204959A (en)	1985-12-13

Publication	Publication Date	Title
FI833047A (fi)	1984-02-27	Mellanprodukter foer framstaellning av omeprazol
FI853625A0 (fi)	1985-09-20	Tetralinderivat, deras framstaellning och anvaendning.
BG33886A3 (en)	1983-05-16	Method for heterocyclic compounds producing
FI812635L (fi)	1982-03-03	Piperidylidenderivat deras framstaellning och dessa innehaollande farmaceutiska blandningar
BG35328A3 (en)	1984-03-15	Method for preparing imidodisulphamidic derivatives
BG35330A3 (en)	1984-03-15	Method for preparing 3- iodine- methylcephalosporines
BG41821A3 (en)	1987-08-14	Method for preparing pyridyl derivatives
BG40968A3 (en)	1987-03-14	Method for preparing heterocyclic compounds
AP8800109A0 (en)	1989-01-31	"Heterocyclic insecticides".
BG38338A3 (en)	1985-11-15	Method for preparing 6 alpha- methylhydrocortisonic derivatives
BG35895A3 (en)	1984-07-16	Method for preparing of n- substituted- 2- haloacetanilides
FI821141L (fi)	1982-10-02	5,6-dihydro-11-alkylen-morfantridin-6-one, deras framstaellning och dessa innehaollande laekemedel
FI830939A0 (fi)	1983-03-21	Foerfarande foer framstaellning av nya derivat av indolizino(8,7-b)indol
GR1000471B (el)	1992-07-30	Μεθοδος παρασκευης κινολινοθειοαιθερων.
BG42001A3 (en)	1987-09-15	Method for preparing of 1- aryl- 2- aminoethanol derivatives
GR880100452A (el)	1989-04-12	Μυκητοκτονες συνθεσεις με βαση νικοτινικα παραγωγα,νεα νικοτινικα παραγωγα και η παρασκευη τους
JPS5283532A (en)	1977-07-12	Novel aromatic compounds
GR1000138B (el)	1991-09-27	Νεα παραγωγα ριβοφουρανουρονικου οξεος, μεθοδος δια την παρασευη αυτων και η χρησιμοποιησις αυτων.
BG35030A3 (en)	1984-01-16	Method for preparing bicyclo (2.2.1) heptanic derivatives

Legal Events

Date	Code	Title	Description
2004-08-31	MA	Patent expired	Owner name: AKTIEBOLAGET HAESSLE