FI83220B - Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,3-dimetyl-1h-purin-2,6-dionderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,3-dimetyl-1h-purin-2,6-dionderivat. Download PDFInfo
- Publication number
- FI83220B FI83220B FI853763A FI853763A FI83220B FI 83220 B FI83220 B FI 83220B FI 853763 A FI853763 A FI 853763A FI 853763 A FI853763 A FI 853763A FI 83220 B FI83220 B FI 83220B
- Authority
- FI
- Finland
- Prior art keywords
- dimethyl
- formula
- purine
- compound
- dione
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Claims (2)
1 N
10 -N-Alk-N (1) 1 $ R 15 i vilken formel Alk är C2.4-alkandiyl, R är väte, hydroxi, C1.4-alkyl, halogen eller metoxi och den streckade linjen är en eventuell bindning mellan kolatomerna 3 och 4, k ä n -netecknat därav, att en förening med formeln 20 CH, I 3 °γΝ YN^ {II) CH3-N -N-Alk-W 25 0 där Alk betecknar samma som ovan och W är en reaktiv av-gäende grupp, företrädesvis halogen, omsätts med ett pipe-rldinderivat med formeln 30 R II 17 83220 där R och den streckade Iinjen betecknar samma som ovan, företrädesvis i ett i förhällande till reaktionen inert lösningsmedel; och, om sä önskas, omvandlas en erhällen förening med formeln I pä och i för sig känt sätt tili en 5 annan förening med formeln I och/eller omvandlas en förening med formeln I tili ett farmaceutiskt godtagbart syra-additionssalt genom användning av en lämplig syra eller omvandlas ett syraadditionssalt tili en fri bas genom användning av en alkali och/eller omvandlas en förening med 10 formeln I tili en stereokemisk isomerform.
1. Förfarande för framställning av nya terapeutiskt användbara 1,3-dimetyl-lH-purin-2,6-dionderivat med for-5 mein I och farmaceutiskt godtagbara syraadditionssalter därav, CH,
2. Förfarande enligt patentkravet 1 för framställ-ning av 7-[2-[4-(lH-indol-3-yl)-l-piperidinyl]etyl]-3,7-dihydro-1,3-dimetyl-lH-purin-2,6-dion eller ett farmaceutiskt godtagbart syraadditionssalt därav, k ä n n e -15 tecknat därav, att en förening med formeln II, där Alk är -CH2CH2- och W är klor, brom eller jod, omsätts med 3-(4-piperidinyl)-lH-indol i ett i förhällande tili reaktionen inert lösningsmedel eventuellt i närvaro av en bas och, om sä önskas, omvandlas den erhällna föreningen tili 20 ett farmaceutiskt godtagbart syraadditionssalt genom användning en lämplig syra eller omvandlas det erhällna sy-raadditionssaltet tili fri bas genom användninig av alka li.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65656184 | 1984-10-01 | ||
| US06/656,561 US4548939A (en) | 1984-10-01 | 1984-10-01 | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI853763A0 FI853763A0 (fi) | 1985-09-30 |
| FI853763L FI853763L (fi) | 1986-04-02 |
| FI83220B true FI83220B (fi) | 1991-02-28 |
| FI83220C FI83220C (sv) | 1991-06-10 |
Family
ID=24633577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI853763A FI83220C (sv) | 1984-10-01 | 1985-09-30 | Förfarande för framställning av terapeutiskt användbara 1,3-dimetyl-1H -purin-2,6-dionderivat |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4548939A (sv) |
| EP (1) | EP0177087B1 (sv) |
| JP (1) | JPH0653742B2 (sv) |
| CN (1) | CN1011311B (sv) |
| AT (1) | ATE60604T1 (sv) |
| AU (1) | AU576386B2 (sv) |
| CA (1) | CA1262348A (sv) |
| DE (1) | DE3581577D1 (sv) |
| DK (1) | DK163996C (sv) |
| ES (1) | ES8609324A1 (sv) |
| FI (1) | FI83220C (sv) |
| GR (1) | GR852375B (sv) |
| IE (1) | IE58747B1 (sv) |
| NO (1) | NO162069C (sv) |
| NZ (1) | NZ213498A (sv) |
| PT (1) | PT81229B (sv) |
| ZA (1) | ZA857553B (sv) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH648559A5 (de) * | 1981-07-20 | 1985-03-29 | Siegfried Ag | Theophyllinderivate und verfahren zu deren herstellung. |
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| AU611469B2 (en) * | 1987-08-13 | 1991-06-13 | Glaxo Group Limited | Indole derivatives |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| DK733788A (da) * | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
| GB8819024D0 (en) * | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| DK292A (da) * | 1991-11-29 | 1992-01-02 | Tanisake Kk | Middel |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| CN108042542A (zh) * | 2007-06-22 | 2018-05-18 | 海德拉生物科学公司 | 用于治疗病症的方法和组合物 |
| US8318728B2 (en) | 2008-05-14 | 2012-11-27 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
| FR2334358A1 (fr) * | 1975-12-12 | 1977-07-08 | Sogeras | Nouveaux medicaments derives de l'indole |
| FR2362628A1 (fr) * | 1976-08-26 | 1978-03-24 | Roussel Uclaf | Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments |
| EP0011399A1 (en) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them |
| DE2922159A1 (de) * | 1979-05-31 | 1980-12-04 | Boehringer Mannheim Gmbh | Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
| US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
| US4359468A (en) * | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| CH648559A5 (de) * | 1981-07-20 | 1985-03-29 | Siegfried Ag | Theophyllinderivate und verfahren zu deren herstellung. |
-
1984
- 1984-10-01 US US06/656,561 patent/US4548939A/en not_active Expired - Fee Related
-
1985
- 1985-07-30 CN CN85105804A patent/CN1011311B/zh not_active Expired
- 1985-09-10 CA CA000490317A patent/CA1262348A/en not_active Expired
- 1985-09-16 NZ NZ213498A patent/NZ213498A/en unknown
- 1985-09-18 AT AT85201484T patent/ATE60604T1/de not_active IP Right Cessation
- 1985-09-18 DE DE8585201484T patent/DE3581577D1/de not_active Expired - Fee Related
- 1985-09-18 EP EP85201484A patent/EP0177087B1/en not_active Expired - Lifetime
- 1985-09-27 JP JP60212731A patent/JPH0653742B2/ja not_active Expired - Lifetime
- 1985-09-30 AU AU48124/85A patent/AU576386B2/en not_active Ceased
- 1985-09-30 IE IE240385A patent/IE58747B1/en not_active IP Right Cessation
- 1985-09-30 FI FI853763A patent/FI83220C/sv not_active IP Right Cessation
- 1985-09-30 GR GR852375A patent/GR852375B/el unknown
- 1985-09-30 NO NO853856A patent/NO162069C/no unknown
- 1985-09-30 ZA ZA857553A patent/ZA857553B/xx unknown
- 1985-09-30 ES ES547447A patent/ES8609324A1/es not_active Expired
- 1985-09-30 DK DK444085A patent/DK163996C/da not_active IP Right Cessation
- 1985-10-01 PT PT81229A patent/PT81229B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0177087A2 (en) | 1986-04-09 |
| ES8609324A1 (es) | 1986-07-16 |
| NZ213498A (en) | 1988-04-29 |
| DK163996B (da) | 1992-04-27 |
| IE58747B1 (en) | 1993-11-03 |
| FI853763L (fi) | 1986-04-02 |
| JPH0653742B2 (ja) | 1994-07-20 |
| NO162069C (no) | 1989-11-01 |
| JPS6187681A (ja) | 1986-05-06 |
| AU576386B2 (en) | 1988-08-25 |
| EP0177087A3 (en) | 1986-06-11 |
| DK444085A (da) | 1986-04-02 |
| ATE60604T1 (de) | 1991-02-15 |
| ZA857553B (en) | 1987-05-27 |
| US4548939A (en) | 1985-10-22 |
| DK163996C (da) | 1992-09-21 |
| PT81229A (en) | 1985-11-01 |
| PT81229B (pt) | 1987-11-30 |
| AU4812485A (en) | 1986-04-10 |
| DK444085D0 (da) | 1985-09-30 |
| CA1262348A (en) | 1989-10-17 |
| NO162069B (no) | 1989-07-24 |
| ES547447A0 (es) | 1986-07-16 |
| EP0177087B1 (en) | 1991-01-30 |
| CN1011311B (zh) | 1991-01-23 |
| CN85105804A (zh) | 1986-10-22 |
| FI83220C (sv) | 1991-06-10 |
| FI853763A0 (fi) | 1985-09-30 |
| NO853856L (no) | 1986-04-02 |
| IE852403L (en) | 1986-04-01 |
| GR852375B (sv) | 1986-01-31 |
| DE3581577D1 (de) | 1991-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK169073B1 (da) | (4-piperidinylmethyl og -hetero)puriner, præparater indeholdende disse samt fremgangsmåde til fremstilling af disse purinforbindelser | |
| AU671836B2 (en) | Fused imidazole and triazole derivatives as 5-HT1 receptor agonists | |
| EP0464558B1 (en) | Antimigraine alkoxypyrimidine derivatives | |
| FI83220B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,3-dimetyl-1h-purin-2,6-dionderivat. | |
| CS227690B2 (en) | Manufacture of derivatives of 5h-thiazolo-and 5h-1,3,4-thiadiazolo/3,2-a/pirimidin-5-pyrimidin-5-on and 3,4-dihydro-2h,6h-pyrimido/2,1-b/ /1,3/-thiazin-6-on | |
| PT98168B (pt) | Processo para a preparacao de novos derivados do indole e de composicoes farmaceuticas que os contem | |
| RU2146256C1 (ru) | ПРОИЗВОДНЫЕ АЗОЛА И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ С АКТИВНОСТЬЮ В ОТНОШЕНИИ СЕРОТОНИНОВОГО (5-HT1Dα)РЕЦЕПТОРА | |
| US5053411A (en) | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | |
| JPH072839A (ja) | 縮合５員複素環化合物、それらの調製方法及びこれらの化合物を含む医薬組成物 | |
| HU211874A9 (en) | Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same | |
| PT98366B (pt) | Processo para a preparacao de novos derivados de tiazolilo substituido e de pitidinilo substituido e de composicoes farmaceuticas que os contem | |
| EP0223344A1 (en) | Gamma-carbolines | |
| CA2210913C (en) | Antipsychotic 4-(1h-indolyl-1-yl)-1-substituted piperidine derivatives | |
| AU606778B2 (en) | Derivatives of 2-{(4-piperidinyl)methyl}-1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics | |
| RU2156249C2 (ru) | Соединения фенилиндола | |
| CS248020B2 (en) | Production method of the (+)-enantiomere or (+-)-racemical 4a,9b-trans-hexahydro-1h-pyridoindole derivatives | |
| EP0719264B1 (en) | Imidazolone and oxazolone derivatives as dopamine antagonists | |
| US5641787A (en) | Indole derivatives as dopamine D4 antagonists | |
| JPH0733744A (ja) | インダゾール誘導体およびその塩 | |
| FI81800B (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2-bensisoxazol-3-yl-1-piperidinylalkylpyridopyrimidinon- och -tiazolopyrimidinonderivat. | |
| JPH07165754A (ja) | ヘテロアリールピペリジン、その製造方法およびそれを含有する医薬組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: JANSSEN PHARMACEUTICA N.V. |