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FI831049A0 - NYA CYCLOALKA / C / PYRROLKARBONSYRADERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDEAEMNEN OCH DERAS ANVAENDNING SAMT NYA CYKLOALKA / C / PYRROLKARBONSYROR FOSDER OOSOM MELLAN - Google Patents

NYA CYCLOALKA / C / PYRROLKARBONSYRADERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDEAEMNEN OCH DERAS ANVAENDNING SAMT NYA CYKLOALKA / C / PYRROLKARBONSYROR FOSDER OOSOM MELLAN

Info

Publication number
FI831049A0
FI831049A0 FI831049A FI831049A FI831049A0 FI 831049 A0 FI831049 A0 FI 831049A0 FI 831049 A FI831049 A FI 831049A FI 831049 A FI831049 A FI 831049A FI 831049 A0 FI831049 A0 FI 831049A0
Authority
FI
Finland
Prior art keywords
nya
pyrrolkarbonsyror
pyrrolkarbonsyraderivat
oosom
innehaollandeaemnen
Prior art date
Application number
FI831049A
Other languages
Finnish (fi)
Other versions
FI831049A7 (en
FI831049L (en
Inventor
Rainer Henning
Hansjoerg Urbach
Rolf Geiger
Volker Teetz
Reinhard Becker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI831049A0 publication Critical patent/FI831049A0/en
Publication of FI831049A7 publication Critical patent/FI831049A7/en
Publication of FI831049L publication Critical patent/FI831049L/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI831049A 1982-03-30 1983-03-28 NYA CYCLOALKA / C / PYRROLKARBONSYRADERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDEAEMNEN OCH DERAS ANVAENDNING SAMT NYA CYKLOALKA / C / PYRROLKARBONSYROR FOSDER OOSOM MELLAN FI831049L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823211676 DE3211676A1 (en) 1982-03-30 1982-03-30 NEW DERIVATIVES OF CYCLOALKA (C) PYRROL CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF, THEIR SUBSTANCES AND THE USE THEREOF AND NEW CYCLOALKA (C) PYRROL CARBONIC ACIDS AS THE INTERMEDIATE LEVELS AND METHODS

Publications (3)

Publication Number Publication Date
FI831049A0 true FI831049A0 (en) 1983-03-28
FI831049A7 FI831049A7 (en) 1983-10-01
FI831049L FI831049L (en) 1983-10-01

Family

ID=6159702

Family Applications (1)

Application Number Title Priority Date Filing Date
FI831049A FI831049L (en) 1982-03-30 1983-03-28 NYA CYCLOALKA / C / PYRROLKARBONSYRADERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDEAEMNEN OCH DERAS ANVAENDNING SAMT NYA CYKLOALKA / C / PYRROLKARBONSYROR FOSDER OOSOM MELLAN

Country Status (17)

Country Link
EP (1) EP0090362A3 (en)
JP (1) JPS58177967A (en)
KR (1) KR840004069A (en)
AU (1) AU560124B2 (en)
CA (1) CA1198118A (en)
DE (1) DE3211676A1 (en)
DK (1) DK144783A (en)
ES (2) ES8401937A1 (en)
FI (1) FI831049L (en)
GR (1) GR78157B (en)
HU (1) HU193876B (en)
IL (1) IL68267A (en)
NO (2) NO831168L (en)
NZ (1) NZ203719A (en)
PH (1) PH19003A (en)
PT (1) PT76472B (en)
ZA (1) ZA832229B (en)

Families Citing this family (44)

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DE3226768A1 (en) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3246503A1 (en) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (5.3.0) -DECAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THE USE THEREOF
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (en) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED AMINO ACIDS AND THEIR ESTERS
FI841052A7 (en) * 1983-03-16 1984-09-17 Usv Pharma Corp FOERENINGAR FOER BEHANDLING AV BLODTRYCKSSJUKDOMAR.
FR2546886B2 (en) * 1983-06-06 1986-05-16 Adir DERIVATIVES OF ISOINDOLEDICARBOXYLIC ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333455A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3410732A1 (en) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt METHOD FOR TREATING GLAUCOMA
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (en) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt METHOD FOR TREATING HEART INSUFFICIENCY
ZA855659B (en) * 1984-07-30 1987-03-25 Schering Corp Novel process for the preparation of cis,endo-octahydrocyclopenta(b)pyrrole-2-carboxylate
DE3431541A1 (en) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt CIS, ENDO-2-AZABICYCLOALKAN-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (en) * 1986-10-02 1988-04-14 Hoechst Ag COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS WITH CALCIUMANTAGONISTS AND THEIR USE IN MEDICINAL PRODUCTS
DE3639879A1 (en) * 1986-11-21 1988-06-01 Hoechst Ag METHOD FOR PRODUCING MONO, BI AND TRICYCLIC AMINO ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD, AND A METHOD FOR PRODUCING THE SAME
DE3722007A1 (en) * 1987-07-03 1989-01-12 Hoechst Ag METHOD FOR PRODUCING BICYCLIC AMINOCARBONIC ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD AND THE USE THEREOF
JPH0278659A (en) * 1988-09-12 1990-03-19 Shionogi & Co Ltd Compound of azabicycloalkanes
DE3839127A1 (en) * 1988-11-19 1990-05-23 Hoechst Ag PYRROLIDONE-2-CARBONIC ACID DERIVATIVES WITH PSYCHOTROPER EFFECT
DD284030A5 (en) 1988-11-24 1990-10-31 Hoechst Ag,De PROCESS FOR THE PREPARATION OF PEPTIDES WITH BRADYKININ-ANTAGONISTIC EFFECT
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (en) 1996-03-20 1998-05-29 Roussel Uclaf NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE59706273D1 (en) 1996-03-20 2002-03-21 Hoechst Ag Bone resorption inhibitors and vitronectin receptor antagonists
ATE212037T1 (en) 1996-10-18 2002-02-15 Vertex Pharma INHIBITORS OF SERINE PROTEASES, IN PARTICULAR THE NS3 PROTEASE OF THE HEPATITIS C VIRUS
DE19653647A1 (en) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin receptor antagonists, their preparation and their use
DE19741235A1 (en) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE19741873A1 (en) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them
DE19751251A1 (en) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them
DE19821483A1 (en) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
SV2003000617A (en) 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
UY28500A1 (en) 2003-09-05 2005-04-29 Vertex Pharma INHIBITORS OF SERINE PROTEASES, IN PARTICULAR PROTEASA NS3-NS4A HCV.
SI1934179T1 (en) * 2005-08-19 2010-08-31 Vertex Pharma Processes and intermediates
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (en) 2005-08-26 2007-08-22 Vertex Pharma INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
WO2007109080A2 (en) 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
EP2463285A1 (en) 2007-02-27 2012-06-13 Vertex Pharmaceuticals Inc. Co-crystals and pharmaceutical compositions comprising the same
CA2679426A1 (en) 2007-02-27 2008-09-04 Luc Farmer Inhibitors of serine proteases
TW200922933A (en) 2007-08-30 2009-06-01 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
CN102816106A (en) 2008-06-24 2012-12-12 默沙东公司 Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
JP5829529B2 (en) * 2011-08-29 2015-12-09 日本曹達株式会社 Optically active quaternary ammonium salt and method for producing optically active compound

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DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT76472A (en) 1983-04-01
ES8402570A1 (en) 1984-02-01
AU1297083A (en) 1983-10-06
FI831049A7 (en) 1983-10-01
ES521741A0 (en) 1984-02-01
HU193876B (en) 1987-12-28
ES521041A0 (en) 1984-01-01
EP0090362A3 (en) 1985-09-18
ES8401937A1 (en) 1984-01-01
IL68267A (en) 1987-03-31
NO834352L (en) 1983-10-03
IL68267A0 (en) 1983-06-15
DK144783D0 (en) 1983-03-29
JPS58177967A (en) 1983-10-18
PT76472B (en) 1986-01-24
DE3211676A1 (en) 1983-10-06
CA1198118A (en) 1985-12-17
NZ203719A (en) 1986-02-21
GR78157B (en) 1984-09-26
DK144783A (en) 1983-10-01
PH19003A (en) 1985-12-03
AU560124B2 (en) 1987-04-02
FI831049L (en) 1983-10-01
EP0090362A2 (en) 1983-10-05
ZA832229B (en) 1983-12-28
KR840004069A (en) 1984-10-06
NO831168L (en) 1983-10-03

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Owner name: HOECHST AKTIENGESELLSCHAFT