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FI82940B - Foerfarande foer framstaellning av som laekemedel anvaendbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider. - Google Patents

Foerfarande foer framstaellning av som laekemedel anvaendbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider. Download PDF

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Publication number
FI82940B
FI82940B FI862850A FI862850A FI82940B FI 82940 B FI82940 B FI 82940B FI 862850 A FI862850 A FI 862850A FI 862850 A FI862850 A FI 862850A FI 82940 B FI82940 B FI 82940B
Authority
FI
Finland
Prior art keywords
complex
iii
process according
phosphatidylcholine
phospholipids
Prior art date
Application number
FI862850A
Other languages
English (en)
Finnish (fi)
Other versions
FI862850A (fi
FI862850A0 (fi
FI82940C (sv
Inventor
Giorgio Pifferi
Ezio Bombardelli
Bruno Gabetta
Original Assignee
Idb Holding Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11184188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI82940(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idb Holding Spa filed Critical Idb Holding Spa
Publication of FI862850A0 publication Critical patent/FI862850A0/fi
Publication of FI862850A publication Critical patent/FI862850A/fi
Application granted granted Critical
Publication of FI82940B publication Critical patent/FI82940B/fi
Publication of FI82940C publication Critical patent/FI82940C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (8)

1. Förfarande för framställning av som läkemedel användbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider raed formeln 5 (I> CH2-0-R »···, "yVt···’1 /.s W^- „ ' OH O CH-O-P
2 Il\ © O °~R2 15 ddr R och R,, som är likadana eller olika, vardera avser acylresten av 2Q painitin-, stearin-, olein-, linolein- eller linolensyra; R^* avser en av resterna -CHj-CHj-iKCHj),, -CHjCHj-NH, eller -CHjCH(COOH) -NHjj och R3 avser en av radikalerna a,b eller c: OH 25 ‘j0 rr [I A CH OH 2 30 tal <b> ji ' °H 35 (C, 2i 82940 1 varvld molförhillandet mailan flavanolignanerna och fosfolipiderna varie-rar mailan 1:0,3 och 1:2, kAnnetecknat dArav, att man bringar en eller flera naturliga eller syntetiska fosfollpider med formeIn (II) att reagera i aprotiska lösnlngsmedel med en eller flera flavanolignaner g med formeln (III) ch2-o-r I H° ,-'R3 CH-O-R, Tili 10 /0© W^H / OH o CH -O-P (III) 15 (ID (dAr R.R^R, och R, har samma betydelse som tldigare) i molförhillanden melian flavanollgnan och fosfollpid som Ar mellan 1:0,3 och 1:2, och de resulterande kömpiexen Atervlnnes genom utfAlining i olosiiga lösnlngs-20 medel, frystorknlng eller spraytorknlng.
2. Förfarande enligt patentkrav 1, kanne tecknat dArav, att det aprotiska lösnlngsmedlet Ar valt frin en grupp som bestir av dloxan och aceton, och det olösliga lösnlngsmedlet Ar valt frin en grupp som 25 bestir av allfatlska kolvAten och blandnlngar av dessa.
3. Förfarande enligt patentkraven 1-2, kinnetecknat dArav, att flavanollgnanen (III) Ar silybin och fosfollplden (II) Ar fosfatldyl-kolin. 30
4. Förfarande enligt patnetkraven 1-2, kAnnetecknat dArav, att flavanollgnanen (III) Ar sllikristln och fosfollplden (II) Ar dipalmi-toyl-fosfatldyletanolamln. 25 5. Förfarande enligt patentkraven 1-2, kAnnetecknat därav, att flavanollgnanen (III) Ar sllldlanln och fosfollplden (II) Ar distea-royl-fosfatidylkolin. 22 82940 1 6. Förfarande enllgt patentkraven 1-5, kännetecknat därav, att flavanolignanen (III) och fosfolipiden (II) är närvarande i ett molförhällande pa 1:1. 5 7. Förfarande enligt patentkraven 1-2, kännetecknat därav, att flavanolignanen (III) är silymarin och fosfolipiden (II) är fosfatidyl-kolin fran soja.
8. Förfarande enligt patentkrav 7, kännetecknat därav, att 10 silymarinen och fosfatidylkolinen fran soja är närvarande i ett molfor-h! Hand e som varierar melian 1:0,3, 1:1 och 1.2. 15 20 25 30 35
FI862850A 1985-07-17 1986-07-04 Förfarande för framställning av som läkemedel användbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider FI82940C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2160285 1985-07-17
IT8521602A IT1215291B (it) 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.

Publications (4)

Publication Number Publication Date
FI862850A0 FI862850A0 (fi) 1986-07-04
FI862850A FI862850A (fi) 1987-01-18
FI82940B true FI82940B (fi) 1991-01-31
FI82940C FI82940C (sv) 1991-05-10

Family

ID=11184188

Family Applications (1)

Application Number Title Priority Date Filing Date
FI862850A FI82940C (sv) 1985-07-17 1986-07-04 Förfarande för framställning av som läkemedel användbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider

Country Status (18)

Country Link
US (1) US4764508A (sv)
EP (1) EP0209038B2 (sv)
JP (1) JPH0692399B2 (sv)
KR (1) KR890002430B1 (sv)
AR (1) AR241117A1 (sv)
AT (1) ATE46513T1 (sv)
CA (1) CA1259324A (sv)
CS (1) CS257289B2 (sv)
DE (1) DE3665717D1 (sv)
DK (1) DK170804B1 (sv)
ES (1) ES2002101A6 (sv)
FI (1) FI82940C (sv)
GR (1) GR861825B (sv)
HU (1) HU197332B (sv)
IT (1) IT1215291B (sv)
MX (1) MX3173A (sv)
PT (1) PT82988B (sv)
YU (1) YU45790B (sv)

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IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1222012B (it) * 1987-07-10 1990-08-31 Indena Spa Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
IT1241673B (it) * 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
IT1238684B (it) * 1990-02-09 1993-09-01 Indena Spa Derivati del bilobalide,loro usi e formulazioni che li contegono
DK0464297T3 (da) * 1990-07-05 1995-10-09 Indena Spa Komplekser af neolignanderivater med phospholipider, anvendelsen deraf samt farmaceutiske og kosmetiske formuleringer indeholdende disse
JP2672439B2 (ja) * 1991-09-25 1997-11-05 倉敷紡績 株式会社 強化押出成形体
GB9211659D0 (en) * 1992-06-02 1992-07-15 Indena Spa New alkaloid derivatives,their use and pharmaceutical formulations containing them
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US5922757A (en) * 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
ITMI20010429A1 (it) * 2001-03-02 2002-09-02 Indena Spa Composizioni farmaceutiche e cosmetiche per la protezione della pelledai danni indotti dalle radiazioni solari
KR100385366B1 (ko) * 2001-03-05 2003-05-27 부광약품 주식회사 생체이용율을 개선한 실리마린 제제 조성물
ATE363486T1 (de) 2001-07-27 2007-06-15 Neptune Technologies & Bioress Flavonoide und mehrfach ungesättigte fettsäuren enthaltende natürliche phospholipide maritimen ursprungs sowie deren anwendungen
CA2450770A1 (en) * 2001-08-01 2003-02-13 Altana Pharma Ag Combination of selective cox-2 inhibitor and lung surfactant for respiratory syndrome
CZ292832B6 (cs) * 2001-08-30 2003-12-17 Ivax Pharmaceuticals S.R.O. Způsob přípravy silymarinu se zvýšenou rozpustností
ITMI20031388A1 (it) * 2003-07-08 2005-01-09 Indena Spa Formulazioni per il trattamento e la prevenzione di patologie della prostata.
ITMI20051942A1 (it) * 2005-10-14 2007-04-15 S I I T S R L Servizio Interna Composizioni galattogeniche a base di silimarina
EP1837030A1 (en) 2006-03-09 2007-09-26 INDENA S.p.A. Phospholipid complexes of curcumin having improved bioavailability
EP1844785A1 (en) * 2006-04-13 2007-10-17 Indena S.P.A. Phospholipid complexes of olive fruits or leaves extracts having improved bioavailability
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CZ300846B6 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
US8337835B2 (en) 2009-04-10 2012-12-25 Washington University Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders
IT1395351B1 (it) 2009-07-09 2012-09-14 Axioma Srl Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli
CN104434935B (zh) 2009-10-29 2019-07-16 阿卡斯蒂制药股份有限公司 浓治疗性磷脂组合物
ITMI20121317A1 (it) * 2012-07-27 2014-01-28 Indena Spa Composizioni per il trattamento della fatica oncologica
ITMI20121784A1 (it) 2012-10-22 2014-04-23 Velleja Res Srl Composizioni galattogeniche a base di fosfatidilserina
ITMI20130425A1 (it) * 2013-03-20 2014-09-21 Istituto Biochimico Italiano Composizione per il trattamento della sindrome metabolica e delle alterazioni metabolico-ossidative nei pazienti con steatoepatite non alcolica (nash)
CN103751785A (zh) * 2014-01-27 2014-04-30 江苏健佳药业有限公司 一种水飞蓟素磷脂复合物及其制备方法
CN104306332B (zh) * 2014-09-24 2017-02-15 东南大学 一种喜树碱类磷脂化合物、其药物组合物及应用
CN105983014A (zh) * 2015-03-23 2016-10-05 天士力制药集团股份有限公司 一种含有水飞蓟宾、ve和左旋肉碱的药物组合物
CN105983016B (zh) * 2015-03-23 2023-08-11 天士力医药集团股份有限公司 一种含有水飞蓟宾的药物组合
ITUB20155532A1 (it) * 2015-11-12 2017-05-12 St Biochimico Italiano Giovanni Lorenzini Spa Formulazione farmaceutica orale comprendente silibina
IT201600105201A1 (it) 2016-10-19 2018-04-19 Nutrilinea Srl Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche
WO2019070109A1 (es) * 2017-10-03 2019-04-11 Infinite Clinical Research International, S.A. De C.V. Triconjugado para el tratamiento de diabetes mellitus
CN117715634A (zh) 2021-05-18 2024-03-15 普罗斯塔西斯有限责任公司 包含化合物的混合物的组合物及其用途

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SE442562B (sv) * 1983-01-26 1986-01-13 Asea Ab Sett att innesluta radioaktivt eller annat farligt avfall och en behallare for sadant avfall

Also Published As

Publication number Publication date
FI862850A (fi) 1987-01-18
EP0209038B2 (en) 1996-03-27
FI862850A0 (fi) 1986-07-04
MX3173A (es) 1993-09-01
KR870001188A (ko) 1987-03-12
US4764508A (en) 1988-08-16
CS257289B2 (en) 1988-04-15
HU197332B (en) 1989-03-28
IT1215291B (it) 1990-01-31
DE3665717D1 (en) 1989-10-26
PT82988A (en) 1986-08-01
DK339086A (da) 1987-01-18
CA1259324A (en) 1989-09-12
IT8521602A0 (it) 1985-07-17
GR861825B (en) 1986-11-18
DK170804B1 (da) 1996-01-22
PT82988B (pt) 1988-07-01
DK339086D0 (da) 1986-07-16
AR241117A1 (es) 1991-11-15
AR241117A2 (es) 1991-11-15
KR890002430B1 (ko) 1989-07-03
ES2002101A6 (es) 1988-07-16
YU128086A (en) 1988-02-29
EP0209038A1 (en) 1987-01-21
EP0209038B1 (en) 1989-09-20
ATE46513T1 (de) 1989-10-15
FI82940C (sv) 1991-05-10
YU45790B (sh) 1992-07-20
JPH0692399B2 (ja) 1994-11-16
JPS6222781A (ja) 1987-01-30
HUT44567A (en) 1988-03-28

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