[go: up one dir, main page]

FI812652L - Aminosyraderivat foerfarande foer deras framstaellning dessa innehaollande aemnen och deras anvaendning - Google Patents

Aminosyraderivat foerfarande foer deras framstaellning dessa innehaollande aemnen och deras anvaendning

Info

Publication number
FI812652L
FI812652L FI812652A FI812652A FI812652L FI 812652 L FI812652 L FI 812652L FI 812652 A FI812652 A FI 812652A FI 812652 A FI812652 A FI 812652A FI 812652 L FI812652 L FI 812652L
Authority
FI
Finland
Prior art keywords
deras
aminosyraderivat
foerfarande foer
anvaendning
framstaellning
Prior art date
Application number
FI812652A
Other languages
English (en)
Other versions
FI90072C (fi
FI90072B (fi
Inventor
Rolf Geiger
Volker Teetz
Hansjoerg Urbach
Bernward Schoelkens
Rainer Henning
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25787513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI812652(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19803032709 external-priority patent/DE3032709A1/de
Priority claimed from DE19813118191 external-priority patent/DE3118191A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI812652L publication Critical patent/FI812652L/fi
Priority to FI914555A priority Critical patent/FI90069C/fi
Priority to FI914554A priority patent/FI90532C/fi
Application granted granted Critical
Publication of FI90072B publication Critical patent/FI90072B/fi
Publication of FI90072C publication Critical patent/FI90072C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI812652A 1980-08-30 1981-08-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara tetrahydroisokinolinderivat FI90072C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI914555A FI90069C (fi) 1980-08-30 1991-09-27 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dihydroindolderivat
FI914554A FI90532C (fi) 1980-08-30 1991-09-27 Menetelmä uusien terapeuttisesti käyttökelpoisten oktahydroindolijohdannaisten valmistamiseksi

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3032709 1980-08-30
DE19803032709 DE3032709A1 (de) 1980-08-30 1980-08-30 Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE19813118191 DE3118191A1 (de) 1981-05-08 1981-05-08 Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3118191 1981-05-08

Publications (3)

Publication Number Publication Date
FI812652L true FI812652L (fi) 1982-03-01
FI90072B FI90072B (fi) 1993-09-15
FI90072C FI90072C (fi) 1993-12-27

Family

ID=25787513

Family Applications (1)

Application Number Title Priority Date Filing Date
FI812652A FI90072C (fi) 1980-08-30 1981-08-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara tetrahydroisokinolinderivat

Country Status (18)

Country Link
US (2) US5158959A (fi)
EP (2) EP0046953B1 (fi)
JP (3) JPS5777672A (fi)
KR (3) KR850001269B1 (fi)
AR (2) AR240949A1 (fi)
AU (2) AU599151B2 (fi)
CS (1) CS409491A3 (fi)
DE (2) DE3177130D1 (fi)
DK (1) DK169382B1 (fi)
ES (3) ES504955A0 (fi)
FI (1) FI90072C (fi)
GR (1) GR75331B (fi)
HU (1) HU189531B (fi)
IE (1) IE67438B1 (fi)
NO (1) NO812933L (fi)
NZ (1) NZ198195A (fi)
PH (1) PH16812A (fi)
PT (1) PT73584B (fi)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (fi) * 1981-03-19 1985-05-11 Usv Pharma Corp
JPS5833430A (ja) * 1981-03-25 1983-02-26 Showa Denko Kk 吹込成形金型
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0079522B1 (en) * 1981-11-09 1986-05-07 Merck & Co. Inc. N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3227055A1 (de) * 1982-07-20 1984-01-26 Hoechst Ag, 6230 Frankfurt Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
FI841052A7 (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
FR2546886B2 (fr) * 1983-06-06 1986-05-16 Adir Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3408923A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Carboxyalkyldipeptidderivate, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
CA1313724C (en) * 1987-02-19 1993-02-16 Shizuo Saito Aminoacid derivatives as antihypertensives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
WO1991007386A1 (en) * 1989-11-21 1991-05-30 Schering Corporation Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
TW197945B (fi) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6489344B1 (en) 1998-06-19 2002-12-03 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) * 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
WO2001004090A2 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
WO2003040115A1 (fr) * 2001-11-09 2003-05-15 Aventis Pharma S.A. Derives de 2-amino-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
EP1392639B1 (en) * 2001-05-03 2008-09-17 Galileo Laboratories, Inc. Pyruvate derivatives
AU2003213092A1 (en) 2002-02-15 2003-09-09 Smithkline Beecham Corporation Syntheses of quinazolinones
WO2003074048A1 (en) * 2002-03-01 2003-09-12 Warner-Lambert Company Llc Method of treating osteoarthritis
DE60333094D1 (de) * 2002-04-17 2010-08-05 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
CN100491358C (zh) * 2002-05-09 2009-05-27 赛特凯恩蒂克公司 嘧啶酮类化合物、组合物及方法
JP2005530785A (ja) 2002-05-09 2005-10-13 サイトキネティクス・インコーポレーテッド 化合物、組成物、及び方法
WO2003103575A2 (en) 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
EP1556357A4 (en) * 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
US6949538B2 (en) * 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004009036A2 (en) 2002-07-23 2004-01-29 Cytokinetics, Inc. Compounds compositions and methods
EP1539180A4 (en) * 2002-08-21 2006-08-30 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
JP2005539062A (ja) * 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
US7557115B2 (en) 2002-09-30 2009-07-07 Cytokinetics, Inc. Compounds, compositions, and methods
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
WO2005041888A2 (en) * 2003-11-03 2005-05-12 Cytokinetics, Inc. Pyrimidin-4-one compounds, compositions and methods
WO2005046588A2 (en) * 2003-11-07 2005-05-26 Cytokinetics, Inc. Compounds, compositions, and methods
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
US7795448B2 (en) * 2004-05-06 2010-09-14 Cytokinetics, Incorporated Imidazoyl-benzamide anti-cancer agents
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
US7504413B2 (en) * 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
SI1679072T1 (sl) * 2005-01-06 2009-02-28 Ipca Lab Ltd Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila
JP2009514865A (ja) * 2005-11-02 2009-04-09 サイトキネティクス・インコーポレーテッド 有糸分裂キネシン阻害剤
CN101143846B (zh) * 2006-09-12 2011-02-02 南京新港医药有限公司 喹那普利拉的金属盐
US8580998B2 (en) 2008-12-11 2013-11-12 University Of Georgia Research Foundation, Inc. Preparation of alkenes by mild thermolysis of sulfoxides
WO2016178591A2 (en) * 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
ES2912316T3 (es) 2018-07-06 2022-05-25 Respiratorius Ab Publ Nuevas amidas broncodilatadoras heteroenlazadas

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501497A (en) * 1964-02-19 1970-03-17 Sterling Drug Inc (1-indolinyl)-lower alkylamidoximes and -amidine
US3472872A (en) * 1964-02-19 1969-10-14 Sterling Drug Inc Indolyl-lower-alkyl-amidoximes
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350633A (en) * 1980-07-01 1982-09-21 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
US5162362A (en) * 1980-08-30 1992-11-10 Hoechst Aktiengesellschaft Octahydroindole-2-carboxylic acids
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4374817A (en) * 1981-08-21 1983-02-22 Fmc Corporation Formulation of phosphate rock slurries
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
US4431644A (en) * 1982-03-08 1984-02-14 Schering Corporation Antihypertensive agents
US4431645A (en) * 1982-03-08 1984-02-14 Schering Corporation Antihypertensive agents
US4490386A (en) * 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines

Also Published As

Publication number Publication date
AR240702A1 (es) 1990-09-28
DK383581A (da) 1982-03-01
JPS5777672A (en) 1982-05-15
AU627741B2 (en) 1992-09-03
JPH0678355B2 (ja) 1994-10-05
JPH01125398A (ja) 1989-05-17
AU599151B2 (en) 1990-07-12
PT73584B (de) 1983-02-08
AU3662589A (en) 1989-10-05
FI90072C (fi) 1993-12-27
NO812933L (no) 1982-03-01
ES505604A0 (es) 1982-11-16
AU544756B2 (en) 1985-06-13
HU189531B (en) 1986-07-28
NZ198195A (en) 1985-02-28
PH16812A (en) 1984-03-06
DK169382B1 (da) 1994-10-17
IE811986L (en) 1982-02-28
JPH07121955B2 (ja) 1995-12-25
AU7928487A (en) 1988-02-04
IE67438B1 (en) 1996-04-03
KR850001270B1 (ko) 1985-09-04
ES8301214A1 (es) 1982-11-16
PT73584A (de) 1981-09-01
AU7471881A (en) 1982-03-11
AR240949A1 (es) 1991-03-27
KR850002743A (ko) 1985-05-15
GR75331B (fi) 1984-07-13
CS409491A3 (en) 1992-05-13
EP0278530A3 (de) 1989-08-02
ES8206471A1 (es) 1982-08-16
KR850001288B1 (ko) 1985-09-09
US5401766A (en) 1995-03-28
ES8301215A1 (es) 1982-11-16
EP0046953A3 (en) 1982-05-05
EP0278530A2 (de) 1988-08-17
ES504955A0 (es) 1982-08-16
KR830006219A (ko) 1983-09-20
EP0046953B1 (de) 1989-12-06
DE3177130D1 (de) 1990-01-11
KR850002742A (ko) 1985-05-15
DE3177311D1 (de) 1994-06-09
EP0046953A2 (de) 1982-03-10
ES505605A0 (es) 1982-11-16
JPH04217994A (ja) 1992-08-07
FI90072B (fi) 1993-09-15
KR850001269B1 (ko) 1985-09-04
US5158959A (en) 1992-10-27

Similar Documents

Publication Publication Date Title
FI811762L (fi) Ml-236b-derivater och deras framstaellning
FI812652L (fi) Aminosyraderivat foerfarande foer deras framstaellning dessa innehaollande aemnen och deras anvaendning
FI813346L (fi) Foerpackningar och omslag foer multienheter
FI813408L (fi) Karbostyril-foereningar kompositioner innehaollande dessa och foerfarande foer deras framstaellning
FI811422L (fi) Anordning foer stamkvistning och roejning
FI813872L (fi) Blekningsaktivator-korn och deras framstaellning
FI813526L (fi) Bensoheterocykliska foereningar och foerfarande foer deras framstaellning
FI802279A7 (fi) Ytbelagt titandioxidpigment och foerfarande foer framstaellning daerav
FI811591L (fi) Stickugn och i denna infoerbar stickvagn
FI810712L (fi) Heterocykliska foereningar deras framstaellning och anvaendning
FI802106A7 (fi) Torkningsfoerfarande och anordning
FI801356A7 (fi) Kodsystem i flerkanalanalysanordning och anordning foer systemet
FI810718L (fi) Slitbana foer daeck och daeck innehaollande en dylik slitbana
FI814163L (fi) Laodgjutningsfoerfarande och gjutanordning
FI813524L (fi) Maleinsyra-anhydridkopolymerater och deras framstaellning
FI812215L (fi) 7-substituerade benzopyrander och foerfarande foer deras framstaellning
FI65643B (fi) Spikplatta jaemte saett och anordning foer tillverkning av densamma
FI812504L (fi) Desinfekterande och steriliserande komposition
FI811532L (fi) Dioxidfoereningar foerfaranden foer deras framstaellning och deras anvaendning
FI813604L (fi) Sek -butylbifenylprodukt och foerfarande foer framstaellning daerav
FI800647A7 (fi) Saett och anordning foer foerstyvning och raetning av startplaotar
FI810916L (fi) Kirurgiskt haeftningsinstrument och styranordning
FI811900L (fi) Larvicider och insekticider
FI801037A7 (fi) Foerfarande foer tillverkning och hopsaettning av laosdelar
FI823488L (fi) Aromatiska formaldehydkondensationspolymerer och tandvaordskompositioner innehaollande dessa

Legal Events

Date Code Title Description
FG Patent granted

Owner name: HOECHST AKTIENGESELLSCHAFT

BB Publication of examined application
MA Patent expired

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH