FI80454B - Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2-piperazino-pteridiner. - Google Patents
Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2-piperazino-pteridiner. Download PDFInfo
- Publication number
- FI80454B FI80454B FI842622A FI842622A FI80454B FI 80454 B FI80454 B FI 80454B FI 842622 A FI842622 A FI 842622A FI 842622 A FI842622 A FI 842622A FI 80454 B FI80454 B FI 80454B
- Authority
- FI
- Finland
- Prior art keywords
- piperazino
- pteridine
- group
- formula
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (4)
1. Förfarande för framställning av farmakologiskt värdefulla 2-piperazinopteridiner med formeln I R1 N N N N- H (I) R2 där Rl är fenyläiky1amino-» dialkylaminogrupp, piperidino-, morfo-lino-, tiomorfolino- eller 1-oxidotiomorfolinogrupp, R2 är dialkylamino-, piperidino-, morfolino-, tiomorfolino-eller 1-oxidotiomorfolinogrupp och R3 är halogenatom, alkoxi-alkyltio-, fenylalkoxi- eller fenylalkyltiogrupp, varvid alkyldelen i respektive fall kan innehalla 1-3 kolatomer, och deras syraadditionssalter, speciellt deras fysiologiskt lampiiga syraadditionssalter med oorganiska eller organiska syror, kännetecknat därav, att a) för framställning av föreningar med den allmänna formeln I, där R3 är en halogenatom, bringas en förening med den allmänna formeln II Rlx^NYN^Z2 I an Rt A n R2 där Rl och R2 avser samma som ovan, 23 80454 R'3 är halogenatom och Z2 är en nukleofiliskt utbytbar grupp, sasom en halogenatom, att reagera med et piperazin med den allmänna formeln II H - N N - H (III) eller b) för framställning av föreningar med den allmänna formeln I, där R3 är alkoxi-, alkylmerkapto-, fenylalkoxi- eller fenyl-alkylmerkaptogrupp, brlngas en förening med den allmänna formeln IV R, . ^ N Nv /N N- H Ύ Y z3^n *2 där R^ och R2 avser samma som ovan och Z3 är en nukloefiliskt utbytbar grupp, sasom en halogenatom, att reagera med en förening med den allmänna formeln V R31 - H (V) där R31 eventuellt är en med fenylgrupp substituerad alkoxi- eller alkylmerkaptogrupp, varvid alkyldelen respektive innehaller 1-3 kolatomer, eller omsättes med dennas aikaiisalt och därefter vid behov överföres en sl erhallen förening med den 24 80454 allmänna formeln I till sitt syraadditionssalt, speciellt till sitt fysiologiskt lämpliga syraadditionssalt med en oorganisk eller organisk syra.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln I Mr 6-bensyltio-4,7-dimorfolino-2-piperazino-pteridin eller dess syraadditionssalt.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln i Mr 6-klor- 4,7-bis-(dimetylamino)-2-piperazino-pteridin eller dess syraadditionssalt.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln I Mr 6-bensyltio-4,7-bis-(dimetylamino)-2-piperazino-pteridin eller dess syraadditionssalt. i!
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3323932 | 1983-07-02 | ||
| DE19833323932 DE3323932A1 (de) | 1983-07-02 | 1983-07-02 | Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI842622A0 FI842622A0 (fi) | 1984-06-29 |
| FI842622A FI842622A (fi) | 1985-01-03 |
| FI80454B true FI80454B (fi) | 1990-02-28 |
| FI80454C FI80454C (sv) | 1990-06-11 |
Family
ID=6203017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI842622A FI80454C (sv) | 1983-07-02 | 1984-06-29 | Förfarande för framställning av farmakologiskt värdefulla 2-piperazino -pteridiner |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0134922B1 (sv) |
| JP (1) | JPS6025991A (sv) |
| AT (1) | ATE39253T1 (sv) |
| AU (1) | AU565105B2 (sv) |
| CA (1) | CA1233179A (sv) |
| DD (1) | DD229990A5 (sv) |
| DE (2) | DE3323932A1 (sv) |
| DK (1) | DK159113C (sv) |
| ES (2) | ES8503352A1 (sv) |
| FI (1) | FI80454C (sv) |
| GB (1) | GB2143232B (sv) |
| HU (1) | HU190932B (sv) |
| IL (1) | IL72265A (sv) |
| NO (1) | NO160920C (sv) |
| NZ (1) | NZ208725A (sv) |
| PH (1) | PH22493A (sv) |
| ZA (1) | ZA844968B (sv) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445298A1 (de) * | 1984-12-12 | 1986-06-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
| DE3540952C2 (de) * | 1985-11-19 | 1997-08-14 | Thomae Gmbh Dr K | 2-Piperazino-pteridine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US7276506B2 (en) | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| DE10202468A1 (de) * | 2002-01-23 | 2004-09-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung |
| ES2295897T3 (es) * | 2003-08-29 | 2008-04-16 | 4 Aza Ip Nv | Efectos inmunodepresores de derivados de pteridina. |
| GB2407089A (en) * | 2003-10-17 | 2005-04-20 | 4 Aza Bioscience Nv | Pteridine derivatives |
| DE102004057645A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057595A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057594A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057618A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| EP2032585B1 (de) | 2006-05-24 | 2014-07-23 | Boehringer Ingelheim International GmbH | Substituierte pteridine als therapeutika |
| WO2007135027A1 (de) * | 2006-05-24 | 2007-11-29 | Boehringer Ingelheim International Gmbh | Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind |
| WO2008003149A2 (en) * | 2006-07-06 | 2008-01-10 | Gilead Sciences , Inc. | Substituted pteridines for the treatment and prevention of viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| WO2008009079A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| EP3722297A1 (en) | 2015-03-04 | 2020-10-14 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| EP3507288B1 (en) | 2016-09-02 | 2020-08-26 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| PL3507276T3 (pl) | 2016-09-02 | 2022-02-21 | Gilead Sciences, Inc. | Związki modulatory receptorów toll-podobnych |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2940972A (en) * | 1957-06-27 | 1960-06-14 | Thomae Gmbh Dr K | Tri-and tetra-substituted pteridine derivatives |
| FR1352111A (fr) * | 1962-01-25 | 1964-02-14 | Lumiere Lab | Triamino ptéridines et leur préparation |
-
1983
- 1983-07-02 DE DE19833323932 patent/DE3323932A1/de not_active Withdrawn
-
1984
- 1984-06-11 ES ES533298A patent/ES8503352A1/es not_active Expired
- 1984-06-19 AT AT84106993T patent/ATE39253T1/de not_active IP Right Cessation
- 1984-06-19 DE DE8484106993T patent/DE3475620D1/de not_active Expired
- 1984-06-19 EP EP84106993A patent/EP0134922B1/de not_active Expired
- 1984-06-28 DK DK316284A patent/DK159113C/da not_active IP Right Cessation
- 1984-06-28 JP JP59132187A patent/JPS6025991A/ja active Pending
- 1984-06-29 NZ NZ208725A patent/NZ208725A/xx unknown
- 1984-06-29 DD DD84264739A patent/DD229990A5/de not_active IP Right Cessation
- 1984-06-29 PH PH30906A patent/PH22493A/en unknown
- 1984-06-29 CA CA000457880A patent/CA1233179A/en not_active Expired
- 1984-06-29 FI FI842622A patent/FI80454C/sv not_active IP Right Cessation
- 1984-06-29 IL IL72265A patent/IL72265A/xx unknown
- 1984-06-29 NO NO842631A patent/NO160920C/no unknown
- 1984-06-29 ZA ZA844968A patent/ZA844968B/xx unknown
- 1984-06-29 GB GB08416682A patent/GB2143232B/en not_active Expired
- 1984-07-02 HU HU842559A patent/HU190932B/hu not_active IP Right Cessation
- 1984-07-02 AU AU30092/84A patent/AU565105B2/en not_active Ceased
- 1984-11-20 ES ES537785A patent/ES8601205A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK316284D0 (da) | 1984-06-28 |
| ES537785A0 (es) | 1985-10-16 |
| EP0134922B1 (de) | 1988-12-14 |
| NO160920C (no) | 1989-06-14 |
| IL72265A0 (en) | 1984-10-31 |
| NO160920B (no) | 1989-03-06 |
| NO842631L (no) | 1985-01-03 |
| ES533298A0 (es) | 1985-02-16 |
| FI80454C (sv) | 1990-06-11 |
| AU3009284A (en) | 1985-01-03 |
| ZA844968B (en) | 1986-03-26 |
| HU190932B (en) | 1986-12-28 |
| FI842622A (fi) | 1985-01-03 |
| IL72265A (en) | 1987-08-31 |
| ES8601205A1 (es) | 1985-10-16 |
| GB2143232B (en) | 1986-11-05 |
| AU565105B2 (en) | 1987-09-03 |
| DK159113B (da) | 1990-09-03 |
| CA1233179A (en) | 1988-02-23 |
| DE3323932A1 (de) | 1985-01-10 |
| DK316284A (da) | 1985-01-03 |
| PH22493A (en) | 1988-09-12 |
| ATE39253T1 (de) | 1988-12-15 |
| HUT34487A (en) | 1985-03-28 |
| DK159113C (da) | 1991-02-18 |
| GB2143232A (en) | 1985-02-06 |
| DD229990A5 (de) | 1985-11-20 |
| JPS6025991A (ja) | 1985-02-08 |
| EP0134922A1 (de) | 1985-03-27 |
| GB8416682D0 (en) | 1984-08-01 |
| ES8503352A1 (es) | 1985-02-16 |
| DE3475620D1 (en) | 1989-01-19 |
| FI842622A0 (fi) | 1984-06-29 |
| NZ208725A (en) | 1988-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: DR. KARL THOMAE GESELLSCHAFT MIT |