[go: up one dir, main page]

FI80450C - Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin - Google Patents

Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin Download PDF

Info

Publication number
FI80450C
FI80450C FI810039A FI810039A FI80450C FI 80450 C FI80450 C FI 80450C FI 810039 A FI810039 A FI 810039A FI 810039 A FI810039 A FI 810039A FI 80450 C FI80450 C FI 80450C
Authority
FI
Finland
Prior art keywords
methyl
formula
dimethylamino
nitro
thio
Prior art date
Application number
FI810039A
Other languages
English (en)
Finnish (fi)
Other versions
FI80450B (fi
FI810039L (fi
Inventor
John Watson Clitherow
John Bradshaw
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI810039L publication Critical patent/FI810039L/fi
Priority to FI894014A priority Critical patent/FI84059C/sv
Publication of FI80450B publication Critical patent/FI80450B/fi
Application granted granted Critical
Publication of FI80450C publication Critical patent/FI80450C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (4)

1. Förfarande för framställning av N-[2-[[5-[(dimetylamino)-metyl]-2-furanylmetyl]-tio]etyl]-N'-metyl-2-nitro-l,1-eten-diamin enligt den allmänna formeln (I) /\ /\ »HN02 Me2NCH2 O CH2SCH2CH2NHCNHMe (I) kännetecknat därav, att en tiol enligt formeln (II) Me2NCH2 N0 CH2SH (II) omsätts med ett alkyleringsmedel enligt formeln (III) CH2 ^ chno2 1 ^ » N-CNHMe (III) CH2
2. Förfarandet enligt patentkravet 1, kännetecknat därav, att tiolen enligt formeln (II) bildas in situ ur syra-additionssalt.
3. N-metyl-a-(nitromety1 en)-1-atsiridin-metanamin, med formeln (III) CH2 _ CHN02
1. H I N-CNHMe (III) CH2
FI810039A 1980-01-08 1981-01-08 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin FI80450C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI894014A FI84059C (sv) 1980-01-08 1989-08-28 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8000581 1980-01-08
GB8000580 1980-01-08
GB8000580 1980-01-08
GB8000581 1980-01-08
GB8039336 1980-12-08
GB8039336 1980-12-08

Publications (3)

Publication Number Publication Date
FI810039L FI810039L (fi) 1981-07-09
FI80450B FI80450B (fi) 1990-02-28
FI80450C true FI80450C (sv) 1990-06-11

Family

ID=27260837

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810039A FI80450C (sv) 1980-01-08 1981-01-08 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin

Country Status (14)

Country Link
JP (1) JPH02167259A (sv)
AR (1) AR225940A1 (sv)
AT (1) AT376966B (sv)
CH (1) CH650257A5 (sv)
DE (1) DE3100364A1 (sv)
DK (1) DK157865C (sv)
ES (1) ES8200673A1 (sv)
FI (1) FI80450C (sv)
FR (1) FR2473044A1 (sv)
HU (1) HU182272B (sv)
NL (1) NL8100068A (sv)
PT (1) PT72320B (sv)
SE (2) SE449747B (sv)
YU (1) YU42372B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IL56265A (en) 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
GR65283B (en) * 1977-12-30 1980-08-01 Crc Ricerca Chim Method for the alkyliosis of 4(5)-merka ptomethyl-imidazoles with aziridin derivatives
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
NO811501L (no) * 1980-05-13 1981-11-16 Crc Ricerca Chim Fremgangsmaate ved fremstilling av etendiaminderivater, samt mellomprodukter for disse

Also Published As

Publication number Publication date
FR2473044B1 (sv) 1984-04-13
SE449747B (sv) 1987-05-18
PT72320B (en) 1982-07-23
SE8502780D0 (sv) 1985-06-05
DK157865C (da) 1990-07-30
FI80450B (fi) 1990-02-28
PT72320A (en) 1981-02-01
CH650257A5 (fr) 1985-07-15
ES498389A0 (es) 1981-11-16
YU42372B (en) 1988-08-31
SE8100074L (sv) 1981-07-09
YU2781A (en) 1983-06-30
AT376966B (de) 1985-01-25
FI810039L (fi) 1981-07-09
DK7181A (da) 1981-07-09
DK157865B (da) 1990-02-26
ES8200673A1 (es) 1981-11-16
HU182272B (en) 1983-12-28
JPH02167259A (ja) 1990-06-27
DE3100364C2 (sv) 1989-12-28
SE460604B (sv) 1989-10-30
ATA3781A (de) 1984-06-15
NL8100068A (nl) 1981-08-03
FR2473044A1 (fr) 1981-07-10
AR225940A1 (es) 1982-05-14
JPH0346465B2 (sv) 1991-07-16
SE8502780L (sv) 1985-06-05
DE3100364A1 (de) 1981-11-19

Similar Documents

Publication Publication Date Title
US3283003A (en) 2-(n-lower alkyl-n-cycloheptyl- and cyclooctylamino) ethyl guanidines
FI80450C (sv) Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin
US4968808A (en) Process for the preparation of nitroethene derivatives
KR840002007B1 (ko) 푸란유도체의 제조방법
CZ288652B6 (cs) Způsob přípravy derivátů kyseliny gama-merkaptokarboxylové
FI76080C (sv) Förfarande för framställning av furanderivat
KR100342142B1 (ko) 신규한중간체및n,n'-가교된비스인돌릴말레이미드를제조하기위한그의용도
US4440938A (en) Process for the preparation of a furan derivative
FI81571C (sv) Förfarande för framställning av N-/2-//5-/(dimetylamino)-metyl/-2-fura nylmetyl/tio/-etyl/-N'-metyl-2-nitro-1,1-etendiamin
FI84060B (fi) Foerfarande foer framstaellning av n-/2-//5-/(dimetylamino)metyl/-2-furanylmetyl/tio/etyl/-n'-metyl-2- nitro-1,1-etendiamin.
FI63753C (sv) Förfarande för framställning av kristallint simetidin
FI82241B (fi) Foerfarande foer framstaellning av n-/2-//5-/(dimetylamino)metyl/-2-furanylmetyl/tio/etyl/-n'-metyl -2-nitro-1,1-etendiamin.
EP0299034B1 (en) Process for the preparation of compounds with antiulcer action
US5932584A (en) Optically active 2,3-dihydroimidazo(1,2-C) quinazoline derivatives, the preparation and antihypertensive use thereof
PL190946B1 (pl) Związki 2-tiotiazolidyn-5-onu, sposoby ich wytwarzania oraz sposoby wytwarzania związków 2-imidazolidyn-5-onu
FI84059C (sv) Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin
US4413135A (en) Intermediates in the preparation of ranitidine
KR840002002B1 (ko) 아지리딘 유도체의 제조방법
JPS642590B2 (sv)
CS233160B1 (cs) Způsob výroby meziproduktů H^-antihistaminik

Legal Events

Date Code Title Description
MA Patent expired

Owner name: GLAXO GROUP LIMITED