FI782680A - 5-substituerade 10,11-dihydro-5h-dibenso(a,d)cyklohepten-5,10-iminer - Google Patents

5-substituerade 10,11-dihydro-5h-dibenso(a,d)cyklohepten-5,10-iminer

Info

Publication number: FI782680A
Authority: FI; Finland
Prior art keywords: iminer; dibenso; cyclohepten; substitutes; dihydro
Prior art date: 1977-09-19

Application number

FI782680A

Other languages

English (en)

Other versions

FI65618C (fi

FI65618B (fi

Inventor

Sandor Karady

Paul Stanley Anderson

Marcia Elizabeth Christy

Ben Edward Evans

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-19

Filing date

1978-09-01

Publication date

1979-03-20

1978-09-01 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1979-03-20 Publication of FI782680A publication Critical patent/FI782680A/fi

1984-02-29 Application granted granted Critical

1984-02-29 Publication of FI65618B publication Critical patent/FI65618B/fi

1984-06-11 Publication of FI65618C publication Critical patent/FI65618C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI782680A 1977-09-19 1978-09-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 10,11-dihydro-5h-dibenso(a d)cyklohepten-5,1 0-miner FI65618C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83463977A	1977-09-19	1977-09-19
US83463977		1977-09-19

Publications (3)

Publication Number	Publication Date
FI782680A true FI782680A (fi)	1979-03-20
FI65618B FI65618B (fi)	1984-02-29
FI65618C FI65618C (fi)	1984-06-11

Family

ID=25267426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI782680A FI65618C (fi)	1977-09-19	1978-09-01	Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 10,11-dihydro-5h-dibenso(a d)cyklohepten-5,1 0-miner

Country Status (33)

Country	Link
JP (1)	JPS5463100A (fi)
AR (1)	AR231544A1 (fi)
AT (1)	AT370103B (fi)
AU (1)	AU520178B2 (fi)
BE (1)	BE870562A (fi)
CA (1)	CA1129850A (fi)
CH (1)	CH637954A5 (fi)
CY (1)	CY1283A (fi)
DE (1)	DE2840786A1 (fi)
DK (1)	DK153843C (fi)
ES (7)	ES473492A1 (fi)
FI (1)	FI65618C (fi)
FR (1)	FR2403334A1 (fi)
GB (2)	GB2004872B (fi)
GR (1)	GR65703B (fi)
HK (1)	HK30885A (fi)
HU (1)	HU180868B (fi)
IE (1)	IE47355B1 (fi)
IL (1)	IL55521A0 (fi)
IT (1)	IT1113279B (fi)
KE (1)	KE3501A (fi)
LU (1)	LU80262A1 (fi)
NL (1)	NL191488C (fi)
NO (1)	NO151861C (fi)
NZ (1)	NZ188361A (fi)
PH (1)	PH15920A (fi)
PL (3)	PL112834B1 (fi)
PT (1)	PT68544A (fi)
SE (1)	SE437520B (fi)
SG (1)	SG9585G (fi)
SU (2)	SU895288A3 (fi)
YU (1)	YU41432B (fi)
ZA (1)	ZA785291B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4232158A (en) *	1979-06-04	1980-11-04	Merck & Co., Inc.	10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) *	1982-04-07	1984-10-16	Merck & Co., Inc.	Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) *	1987-08-13	1987-09-23	Merck Sharp & Dohme	Chemical compounds
US5686614A (en) *	1995-04-11	1997-11-11	Neurogen Corporation	Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) *	1996-03-08	1998-04-14	Neurogen Corporation	Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en)	2015-11-30	2020-03-10	INSERM (Institut National de la Santé et de la Recherche Médicale)	NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE794904A (fr) *	1972-02-04	1973-08-02	Roussel Uclaf	Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) *	1974-05-15	1975-11-14		9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

1978
- 1978-08-28 NL NL7808847A patent/NL191488C/xx not_active IP Right Cessation
- 1978-08-31 SE SE7809187A patent/SE437520B/sv not_active IP Right Cessation
- 1978-09-01 FI FI782680A patent/FI65618C/fi not_active IP Right Cessation
- 1978-09-04 DK DK389978A patent/DK153843C/da not_active IP Right Cessation
- 1978-09-04 NO NO783017A patent/NO151861C/no unknown
- 1978-09-06 NZ NZ188361A patent/NZ188361A/xx unknown
- 1978-09-06 IL IL7855521A patent/IL55521A0/xx not_active IP Right Cessation
- 1978-09-06 PH PH21575A patent/PH15920A/en unknown
- 1978-09-08 AU AU39668/78A patent/AU520178B2/en not_active Expired
- 1978-09-08 GR GR57185A patent/GR65703B/el unknown
- 1978-09-12 PT PT68544A patent/PT68544A/pt unknown
- 1978-09-13 CA CA311,197A patent/CA1129850A/en not_active Expired
- 1978-09-14 AR AR273708A patent/AR231544A1/es active
- 1978-09-15 CH CH969078A patent/CH637954A5/de not_active IP Right Cessation
- 1978-09-15 FR FR7826533A patent/FR2403334A1/fr active Granted
- 1978-09-15 AT AT0669778A patent/AT370103B/de not_active IP Right Cessation
- 1978-09-15 IE IE1866/78A patent/IE47355B1/en not_active IP Right Cessation
- 1978-09-16 PL PL1978209632A patent/PL112834B1/pl unknown
- 1978-09-16 PL PL1978217435A patent/PL118478B1/pl unknown
- 1978-09-16 PL PL1978225938A patent/PL121605B1/pl unknown
- 1978-09-18 SU SU782665603A patent/SU895288A3/ru active
- 1978-09-18 HU HU78ME2204A patent/HU180868B/hu not_active IP Right Cessation
- 1978-09-18 YU YU2196/78A patent/YU41432B/xx unknown
- 1978-09-18 ZA ZA785291A patent/ZA785291B/xx unknown
- 1978-09-18 BE BE190553A patent/BE870562A/xx not_active IP Right Cessation
- 1978-09-18 IT IT51126/78A patent/IT1113279B/it active
- 1978-09-19 GB GB7837284A patent/GB2004872B/en not_active Expired
- 1978-09-19 GB GB8037685A patent/GB2061947B/en not_active Expired
- 1978-09-19 CY CY1283A patent/CY1283A/xx unknown
- 1978-09-19 JP JP11420078A patent/JPS5463100A/ja active Granted
- 1978-09-19 LU LU80262A patent/LU80262A1/xx unknown
- 1978-09-19 ES ES473492A patent/ES473492A1/es not_active Expired
- 1978-09-19 DE DE19782840786 patent/DE2840786A1/de active Granted
1979
- 1979-08-09 ES ES483283A patent/ES483283A1/es not_active Expired
- 1979-08-09 ES ES483287A patent/ES483287A1/es not_active Expired
- 1979-08-09 ES ES483286A patent/ES483286A1/es not_active Expired
- 1979-08-09 ES ES483285A patent/ES483285A1/es not_active Expired
- 1979-08-09 ES ES483284A patent/ES483284A1/es not_active Expired
- 1979-08-09 ES ES483288A patent/ES483288A1/es not_active Expired
- 1979-11-02 SU SU792834514A patent/SU915800A3/ru active
1985
- 1985-02-05 KE KE3501A patent/KE3501A/xx unknown
- 1985-02-07 SG SG95/85A patent/SG9585G/en unknown
- 1985-04-18 HK HK308/85A patent/HK30885A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE7809187L (sv)	1979-03-20
AR231544A1 (es)	1984-12-28
NO151861C (no)	1985-06-19
BE870562A (fr)	1979-03-19
PH15920A (en)	1983-04-22
PL112834B1 (en)	1980-11-29
FI65618C (fi)	1984-06-11
JPS5463100A (en)	1979-05-21
NO783017L (no)	1979-03-20
NL191488C (nl)	1995-08-04
PL209632A1 (pl)	1979-06-04
NL7808847A (nl)	1979-03-21
AU3966878A (en)	1980-03-13
GB2061947A (en)	1981-05-20
LU80262A1 (fr)	1979-06-01
ES483288A1 (es)	1980-04-16
FR2403334B1 (fi)	1982-11-19
GB2061947B (en)	1982-08-04
NZ188361A (en)	1982-06-29
ES483285A1 (es)	1980-09-01
JPS5639315B2 (fi)	1981-09-11
SE437520B (sv)	1985-03-04
NL191488B (nl)	1995-04-03
GB2004872A (en)	1979-04-11
ES483283A1 (es)	1980-04-16
HU180868B (en)	1983-04-29
IL55521A0 (en)	1978-12-17
IE781866L (en)	1979-03-19
NO151861B (no)	1985-03-11
FR2403334A1 (fr)	1979-04-13
IT7851126A0 (it)	1978-09-18
HK30885A (en)	1985-04-26
SU915800A3 (en)	1982-03-23
FI65618B (fi)	1984-02-29
IT1113279B (it)	1986-01-20
ES483287A1 (es)	1980-04-16
CH637954A5 (de)	1983-08-31
DK153843B (da)	1988-09-12
SU895288A3 (ru)	1981-12-30
IE47355B1 (en)	1984-02-22
AT370103B (de)	1983-03-10
GR65703B (en)	1980-10-22
PT68544A (en)	1978-10-01
DE2840786C2 (fi)	1987-05-21
DE2840786A1 (de)	1979-03-22
PL121605B1 (en)	1982-05-31
KE3501A (en)	1985-02-22
PL118478B1 (en)	1981-10-31
ATA669778A (de)	1982-07-15
ES483286A1 (es)	1980-04-16
SG9585G (en)	1985-08-08
CA1129850A (en)	1982-08-17
YU41432B (en)	1987-06-30
YU219678A (en)	1983-02-28
AU520178B2 (en)	1982-01-21
ES473492A1 (es)	1980-07-16
CY1283A (en)	1985-07-05
GB2004872B (en)	1982-04-15
ZA785291B (en)	1980-04-30
DK389978A (da)	1979-03-20
DK153843C (da)	1989-01-23
ES483284A1 (es)	1980-09-01

Publication	Publication Date	Title
FI782823A (fi)	1979-03-17	Foerbaettrad haordloedningskomposition. l: 4b 23k 35/28 a
DK155485C (da)	1989-09-04	Konditionerings-slaamaskine
PL205461A1 (pl)	1979-02-12	Srodek chwastobojczy
PL210379A1 (pl)	1979-07-02	Srodek chwastobojczy
SE7803890L (sv)	1978-10-10	Guajakonsyra a
HK22182A (en)	1982-06-04	1-phenyl-3-azabicyclo(3,1,0)hexan-2-ones
TR19604A (tr)	1979-09-01	2,6-dinitroanilin herbisid terkipler
IT7821697A0 (it)	1978-03-28	Astuccio a cassa.
PL208435A1 (pl)	1979-03-26	Srodek chwastobojczy
FI783032A (fi)	1979-04-07	Foerfarande foer torkning av traemassa. l: 4f 26b 23/02 a
PL207767A1 (pl)	1979-04-09	Srodek chwastobojczy
PL210032A1 (pl)	1979-05-21	Srodek chwastobojczy
PL204307A1 (pl)	1978-11-06	Srodek chwastobojczy
FI801622A (fi)	1980-12-05	10,11-dihydro-5h-dibenso /a d/ cyklohepten-5,10-iminer
FI782680A (fi)	1979-03-20	5-substituerade 10,11-dihydro-5h-dibenso(a,d)cyklohepten-5,10-iminer
IT7829814A0 (it)	1978-11-15	Valvola a farfalla.
IT7830011A0 (it)	1978-11-21	Aloctina a.
IT7820183A0 (it)	1978-02-10	Apparecchiatura a solenoide.
IT7819024A0 (it)	1978-01-04	Apparato depuratore a movimento vorticoso.
IT1096166B (it)	1985-08-17	Agenti funghicidi a base di 3-cloro-4h-1,2,6-tiadiazin-4-one mono-5-sostitutito
ES235674Y (es)	1978-11-16	Un transformador.
PL203976A1 (pl)	1978-10-23	Srodek chwastobojczy
IT1088966B (it)	1985-06-10	13,14-dideidro-prostaglandine
CS909078A2 (en)	1985-06-13	Zpusob vyroby derivatu 9 aminopyrido (1,2 a)pyrimidinu
PL207194A1 (pl)	1979-02-26	Srodek chwastobojczy

Legal Events

Date	Code	Title	Description
1996-04-16	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: MERCK & CO INC.