FI782081A - N-substituerade estrar av 9,10-dihydrolyserinsyror och foerfarande foer deras framstaellning - Google Patents

N-substituerade estrar av 9,10-dihydrolyserinsyror och foerfarande foer deras framstaellning

Info

Publication number: FI782081A
Authority: FI; Finland
Prior art keywords: dihydrolyserinsyror; estrar; substituerade; foerfarande foer; och foerfarande
Prior art date: 1977-07-21

Application number

FI782081A

Other languages

English (en)

Other versions

FI64369B (fi

FI64369C (fi

Inventor

Rudolf Rucman

Original Assignee

Lek Tovarna Farmacevtskih

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-07-21

Filing date

1978-06-29

Publication date

1979-01-22

1978-06-29 Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih

1979-01-22 Publication of FI782081A publication Critical patent/FI782081A/fi

1983-07-29 Publication of FI64369B publication Critical patent/FI64369B/fi

1983-11-10 Application granted granted Critical

1983-11-10 Publication of FI64369C publication Critical patent/FI64369C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI782081A 1977-07-21 1978-06-29 Foerfarande foer framstaellning av n-substituerade estrar av 9,10-dihydrolyserginsyror FI64369C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
YU181977		1977-07-21
YU1819/77A YU40004B (en)	1977-07-21	1977-07-21	Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid

Publications (3)

Publication Number	Publication Date
FI782081A true FI782081A (fi)	1979-01-22
FI64369B FI64369B (fi)	1983-07-29
FI64369C FI64369C (fi)	1983-11-10

Family

ID=25555705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI782081A FI64369C (fi)	1977-07-21	1978-06-29	Foerfarande foer framstaellning av n-substituerade estrar av 9,10-dihydrolyserginsyror

Country Status (11)

Country	Link
US (1)	US4230859A (fi)
EP (1)	EP0000533B1 (fi)
JP (1)	JPS5436296A (fi)
AT (1)	AT363195B (fi)
CS (1)	CS216231B2 (fi)
DE (1)	DE2860896D1 (fi)
ES (1)	ES471716A1 (fi)
FI (1)	FI64369C (fi)
PT (1)	PT68278A (fi)
SU (1)	SU784775A3 (fi)
YU (1)	YU40004B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4563461A (en) *	1983-03-10	1986-01-07	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
FR2584721B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle
FR2584720B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation de derives n-methyles de l'ergoline
US4906639A (en) *	1985-10-01	1990-03-06	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
US4847261A (en) *	1985-10-01	1989-07-11	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties
US4683236A (en) *	1985-10-01	1987-07-28	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
US4968802A (en) *	1985-10-01	1990-11-06	Eli Lilly And Company	Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4734501A (en) *	1985-10-01	1988-03-29	Eli Lilly And Company	N-alkylation of dihydrolysergic acid
US4845224A (en) *	1985-10-01	1989-07-04	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties
US4713384A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4713385A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4762842A (en) *	1985-10-01	1988-08-09	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4772709A (en) *	1985-10-01	1988-09-20	Eli Lilly And Company	Process of making ketoalkanol esters of dihydrolysergic acid
US4714704A (en) *	1985-10-01	1987-12-22	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4939258A (en) *	1985-10-01	1990-07-03	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
US4820713A (en) *	1985-10-01	1989-04-11	Eli Lilly And Company	Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4810710A (en) *	1985-10-01	1989-03-07	Eli Lilly And Company	4-hydroxycyclohexyl 1-isopropyl-9,10-dihydro-lysergate for the treatment of migraine
US4704395A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists
US4704396A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists
US4683237A (en) *	1985-12-20	1987-07-28	Eli Lilly And Company	Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US4782063A (en) *	1987-05-11	1988-11-01	Eli Lilly And Company	Ergoline esters useful as serotonin antagonists
US4835159A (en) *	1987-05-11	1989-05-30	Eli Lilly And Company	Ergoline esters useful as serotonin antagonists
US4981859A (en) *	1987-06-15	1991-01-01		Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
US4931447A (en) *	1987-06-15	1990-06-05	Eli Lilly And Company	Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
JPH01106511U (fi) *	1988-01-02	1989-07-18
JPH02125915U (fi) *	1989-03-29	1990-10-17

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA631701A (en) *		1961-11-28	Sandoz A.G.	Compounds of the lysergic acid series alkylated at the indol nitrogen atom
FR1175276A (fr) *	1956-05-18	1959-03-23	Sandoz Ag	Nouveaux dérivés de la série de l'acide lysergique et leur préparation
CH344731A (de) *	1956-05-18	1960-02-29	Sandoz Ag	Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US3228943A (en) *	1962-06-11	1966-01-11		Lumilysergol derivatives
US3232942A (en) *	1964-06-02	1966-02-01	Sandoz Ltd	1-substituted (+)-lysergol
GB1298277A (en) *	1969-04-18	1972-11-29	Sandoz Ltd	Preparation of ergot peptide alkaloids
US3879554A (en) *	1970-03-20	1975-04-22	Farmaceutici Italia	Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
NL159384B (nl) *	1971-03-13	1979-02-15	Farmaceutici Italia	Werkwijze voor het bereiden van een geneesmiddel met een adrenolytische activiteit, alsmede werkwijze voor het bereiden van een ester van 1-methyl-10-methoxylumilysergol.
DE2330912C3 (de) *	1972-06-22	1979-01-11	Societa Farmaceutici Italia S.P.A., Mailand (Italien)	Verfahren zur Herstellung von Bromergolinverbindungen

1977
- 1977-07-21 YU YU1819/77A patent/YU40004B/xx unknown
1978
- 1978-06-29 FI FI782081A patent/FI64369C/fi not_active IP Right Cessation
- 1978-07-06 AT AT0490078A patent/AT363195B/de not_active IP Right Cessation
- 1978-07-07 US US05/922,692 patent/US4230859A/en not_active Expired - Lifetime
- 1978-07-12 PT PT68278A patent/PT68278A/pt unknown
- 1978-07-14 ES ES471716A patent/ES471716A1/es not_active Expired
- 1978-07-18 DE DE7878100419T patent/DE2860896D1/de not_active Expired
- 1978-07-18 CS CS784790A patent/CS216231B2/cs unknown
- 1978-07-18 EP EP78100419A patent/EP0000533B1/de not_active Expired
- 1978-07-20 SU SU782637592A patent/SU784775A3/ru active
- 1978-07-21 JP JP8850978A patent/JPS5436296A/ja active Granted

Also Published As

Publication number	Publication date
SU784775A3 (ru)	1980-11-30
EP0000533B1 (de)	1981-08-05
JPS5436296A (en)	1979-03-16
AT363195B (de)	1981-07-10
YU40004B (en)	1985-06-30
JPS5648512B2 (fi)	1981-11-16
FI64369B (fi)	1983-07-29
YU181977A (en)	1983-01-21
EP0000533A1 (de)	1979-02-07
FI64369C (fi)	1983-11-10
US4230859A (en)	1980-10-28
CS216231B2 (en)	1982-10-29
ATA490078A (de)	1980-12-15
ES471716A1 (es)	1979-10-01
PT68278A (en)	1978-08-01
DE2860896D1 (en)	1981-11-05

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Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZ