FI77034B - Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-oxo-4h-pyrimido/2,1-a/isokinolin-3- karboxylsyraderivat. - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-oxo-4h-pyrimido/2,1-a/isokinolin-3- karboxylsyraderivat.

Info

Publication number: FI77034B
Authority: FI; Finland
Prior art keywords: vaerdefulla; pharmacologiskt; carboxylsyraderivat; isokinolin; pyrimido
Prior art date: 1983-11-23

Application number

FI844406A

Other languages

English (en)

Other versions

FI77034C (fi

FI844406L (fi

FI844406A0 (fi

Inventor

Ikuo Ueda

Youichi Shiokawa

Takashi Manabe

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-23

Filing date

1984-11-09

Publication date

1988-09-30

1983-11-23 Priority claimed from GB838331228A external-priority patent/GB8331228D0/en

1984-03-06 Priority claimed from GB848405776A external-priority patent/GB8405776D0/en

1984-10-12 Priority claimed from GB848425791A external-priority patent/GB8425791D0/en

1984-11-09 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1984-11-09 Publication of FI844406A0 publication Critical patent/FI844406A0/fi

1985-05-24 Publication of FI844406L publication Critical patent/FI844406L/fi

1988-09-30 Application granted granted Critical

1988-09-30 Publication of FI77034B publication Critical patent/FI77034B/fi

1989-01-10 Publication of FI77034C publication Critical patent/FI77034C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI844406A 1983-11-23 1984-11-09 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-oxo-4h-pyrimido/2,1-a/isokinolin-3- karboxylsyraderivat. FI77034C (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB838331228A GB8331228D0 (en)	1983-11-23	1983-11-23	Pyrimidoisoquinoline derivatives
GB8331228		1983-11-23
GB8405776		1984-03-06
GB848405776A GB8405776D0 (en)	1984-03-06	1984-03-06	Pyrimidoisoquinoline derivatives
GB848425791A GB8425791D0 (en)	1984-10-12	1984-10-12	Pyrimidoisoquinoline derivatives
GB8425791		1984-10-12

Publications (4)

Publication Number	Publication Date
FI844406A0 FI844406A0 (fi)	1984-11-09
FI844406L FI844406L (fi)	1985-05-24
FI77034B true FI77034B (fi)	1988-09-30
FI77034C FI77034C (fi)	1989-01-10

Family

ID=27262222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI844406A FI77034C (fi)	1983-11-23	1984-11-09	Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-oxo-4h-pyrimido/2,1-a/isokinolin-3- karboxylsyraderivat.

Country Status (17)

Country	Link
US (1)	US4673676A (fi)
EP (1)	EP0143001B1 (fi)
KR (2)	KR920008168B1 (fi)
AR (1)	AR243889A1 (fi)
AT (1)	ATE62484T1 (fi)
AU (1)	AU582554B2 (fi)
CA (1)	CA1232605A (fi)
DE (1)	DE3484420D1 (fi)
DK (1)	DK165789C (fi)
ES (2)	ES537928A0 (fi)
FI (1)	FI77034C (fi)
GR (1)	GR81006B (fi)
HU (1)	HU202528B (fi)
IL (1)	IL73586A (fi)
NO (1)	NO162019C (fi)
PH (1)	PH22068A (fi)
SU (1)	SU1512482A3 (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO162019C (no) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) *	1984-06-27	1987-04-28	G. D. Searle & Co.	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
US7964608B2 (en)	2008-01-25	2011-06-21	High Point Pharmaceuticals, Llc	Tricyclic compounds as modulators of TNF-α synthesis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876788A (en) *	1970-08-27	1975-04-08	Burroughs Wellcome Co	Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
US4017625A (en) *	1975-08-01	1977-04-12	Pfizer Inc.	Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
HU173438B (hu) *	1975-11-27	1979-05-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
US4127720A (en) *	1977-09-21	1978-11-28	Bristol-Myers Company	Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
IE51802B1 (en) *	1979-12-03	1987-04-01	Fujisawa Pharmaceutical Co	Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
JPS59172472A (ja) *	1983-03-18	1984-09-29	Fujisawa Pharmaceut Co Ltd	イソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
JPS59172490A (ja) *	1983-03-18	1984-09-29	Fujisawa Pharmaceut Co Ltd	ピリミドイソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
NO162019C (no) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) *	1984-06-27	1987-04-28	G. D. Searle & Co.	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives

1984
- 1984-11-08 NO NO844466A patent/NO162019C/no unknown
- 1984-11-09 US US06/669,865 patent/US4673676A/en not_active Expired - Fee Related
- 1984-11-09 FI FI844406A patent/FI77034C/fi not_active IP Right Cessation
- 1984-11-09 DK DK536184A patent/DK165789C/da active
- 1984-11-14 AU AU35405/84A patent/AU582554B2/en not_active Ceased
- 1984-11-19 CA CA000468159A patent/CA1232605A/en not_active Expired
- 1984-11-21 IL IL73586A patent/IL73586A/xx unknown
- 1984-11-21 GR GR81006A patent/GR81006B/el unknown
- 1984-11-22 KR KR1019840007323A patent/KR920008168B1/ko not_active IP Right Cessation
- 1984-11-22 SU SU843818298A patent/SU1512482A3/ru active
- 1984-11-22 AR AR84298701A patent/AR243889A1/es active
- 1984-11-22 AT AT84308109T patent/ATE62484T1/de not_active IP Right Cessation
- 1984-11-22 EP EP84308109A patent/EP0143001B1/en not_active Expired - Lifetime
- 1984-11-22 DE DE8484308109T patent/DE3484420D1/de not_active Expired - Fee Related
- 1984-11-22 HU HU844338A patent/HU202528B/hu not_active IP Right Cessation
- 1984-11-23 ES ES537928A patent/ES537928A0/es active Granted
- 1984-11-23 PH PH31478A patent/PH22068A/en unknown
1985
- 1985-08-16 ES ES546222A patent/ES8604220A1/es not_active Expired
1991
- 1991-09-25 KR KR1019910016712A patent/KR920001673B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI77034C (fi)	1989-01-10
AR243889A1 (es)	1993-09-30
HU202528B (en)	1991-03-28
CA1232605A (en)	1988-02-09
AU582554B2 (en)	1989-04-06
AU3540584A (en)	1985-05-30
SU1512482A3 (ru)	1989-09-30
IL73586A0 (en)	1985-02-28
NO844466L (no)	1985-05-24
KR920008168B1 (ko)	1992-09-24
ES546222A0 (es)	1986-01-16
EP0143001A2 (en)	1985-05-29
ES8604220A1 (es)	1986-01-16
ES8602786A1 (es)	1985-12-01
FI844406L (fi)	1985-05-24
ATE62484T1 (de)	1991-04-15
DK165789B (da)	1993-01-18
NO162019C (no)	1989-10-25
DE3484420D1 (en)	1991-05-16
KR850003538A (ko)	1985-06-20
EP0143001A3 (en)	1986-03-19
PH22068A (en)	1988-05-20
IL73586A (en)	1988-12-30
KR920001673B1 (ko)	1992-02-22
US4673676A (en)	1987-06-16
DK165789C (da)	1993-06-14
DK536184D0 (da)	1984-11-09
EP0143001B1 (en)	1991-04-10
GR81006B (en)	1985-01-03
FI844406A0 (fi)	1984-11-09
ES537928A0 (es)	1985-12-01
DK536184A (da)	1985-05-24
HUT35674A (en)	1985-07-29
NO162019B (no)	1989-07-17

Publication	Publication Date	Title
FI842597A (fi)	1984-12-30	1,2,4-triazol-3-on- depressionslaekemdel.
FI844777A0 (fi)	1984-12-04	2,2'-iminobisetanolderivat.
FI843169A0 (fi)	1984-08-10	Substituerade 2,6-substituerade pyridinfoereningar.
FI843779A0 (fi)	1984-09-26	Depressionslaekemedel, 1,2,4-triazolonfoereningar.
FI844412A0 (fi)	1984-11-09	Omkopplarnaetdel, speciellt foer televisionsmottagare, vilken naetdel uppvisar en skyddskoppling foer begraensning av primaerstroemmen.
FI80881B (fi)	1990-04-30	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,5-bentsotiazepinderivat.
FI73953B (fi)	1987-08-31	Foerfarande foer framstaellning av jaernoxid.
FI830239L (fi)	1984-07-26	Foerfarande foer regenerering av betningssyror.
FI844051L (fi)	1985-04-19	Foerfarande foer dehalogenering av 6, 6-dibrompenicillansyra-1,1-dioxid.
FI843285A0 (fi)	1984-08-20	Foerfarande foer framstaellning av 16-fluoro-16,17-didehydro-prostanoider.
FI73528B (fi)	1987-06-30	Foerfarande foer kontrollering av en tvaofasig processmaelta av gjutmaessing.
FI842085A0 (fi)	1984-05-24	7-oxo-4-tia-1-azabicyklo/3,2,0/hept-2- en-derivat.
FI840514A (fi)	1984-08-11	Foerfarande foer framstaellning av erytromycin a cyklisk 11,12-karbonat.
FI841640A (fi)	1984-11-13	Separation av 1,8-kineol.
FI842338A0 (fi)	1984-06-08	2-azabicyklo/2.2.2./oktanderivat, foerfarande foer framstaellning av dessa samt dessa innehaollande farmaceutiska aemnen.
FI77034B (fi)	1988-09-30	Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-oxo-4h-pyrimido/2,1-a/isokinolin-3- karboxylsyraderivat.
DE3577559D1 (de)	1990-06-13	4h-pyrimido(2,1-a)isochinolin-4-onderivate.
FI844499L (fi)	1985-05-19	Anordning foer stabilisering av en fraon en frekvensgenerator, speciellt en kvartsgenerator, avgiven frekvens.
FI843527A0 (fi)	1984-09-07	Foerfarande foer framstaellning av dihydroaryloxialkylamino -1,2,4-triazolderivat.
FI840973A (fi)	1984-09-11	Foerfarande jaemte anordning foer tillverkning av takbeklaednad.
FI844050A0 (fi)	1984-10-15	Foerfarande foer framstaellning av 6,6-dibrompenicillansyra-1,1-dioxid.
FI842268A (fi)	1984-12-15	Foerfarande foer framstaellning av 3,4-di -isobutyryloxi-n-metyl-fenetylamin.
FI842053A0 (fi)	1984-05-23	Foerfarande foer aostadkommande av en armerad murverksbalk, jaemte anordning foer genomfoerande av foerfarandet.
FI851563L (fi)	1985-04-19	Foerfarande foer bortdrivande av faoglar, i synnerhet hackspettar.
FI845107A0 (fi)	1984-12-21	Foerfarande foer framstaellning av 3,4,5-trimetoxibensonitril.

Legal Events

Date	Code	Title	Description
1995-06-09	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: FUJISAWA PHARMACEUTICAL CO., LTD