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FI69462C - Foerfarande foer framstaellning av inflammationsmotverkande 4,-diaryl-2-(substituerad tio sulfinyl eller sulfonyl)imida zoderivat - Google Patents

Foerfarande foer framstaellning av inflammationsmotverkande 4,-diaryl-2-(substituerad tio sulfinyl eller sulfonyl)imida zoderivat Download PDF

Info

Publication number
FI69462C
FI69462C FI780428A FI780428A FI69462C FI 69462 C FI69462 C FI 69462C FI 780428 A FI780428 A FI 780428A FI 780428 A FI780428 A FI 780428A FI 69462 C FI69462 C FI 69462C
Authority
FI
Finland
Prior art keywords
thienyl
imidazole
mixture
give
pyridyl
Prior art date
Application number
FI780428A
Other languages
English (en)
Finnish (fi)
Other versions
FI780428A (fi
FI69462B (fi
Inventor
Saul Carl Cherkofsky
Thomas Ray Sharpe
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/865,832 external-priority patent/US4159338A/en
Application filed by Du Pont filed Critical Du Pont
Publication of FI780428A publication Critical patent/FI780428A/fi
Publication of FI69462B publication Critical patent/FI69462B/fi
Application granted granted Critical
Publication of FI69462C publication Critical patent/FI69462C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI780428A 1977-02-09 1978-02-09 Foerfarande foer framstaellning av inflammationsmotverkande 4,-diaryl-2-(substituerad tio sulfinyl eller sulfonyl)imida zoderivat FI69462C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76722077A 1977-02-09 1977-02-09
US76722077 1977-02-09
US86583278 1978-01-05
US05/865,832 US4159338A (en) 1977-02-09 1978-01-05 Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Publications (3)

Publication Number Publication Date
FI780428A FI780428A (fi) 1978-08-10
FI69462B FI69462B (fi) 1985-10-31
FI69462C true FI69462C (fi) 1986-02-10

Family

ID=27117879

Family Applications (1)

Application Number Title Priority Date Filing Date
FI780428A FI69462C (fi) 1977-02-09 1978-02-09 Foerfarande foer framstaellning av inflammationsmotverkande 4,-diaryl-2-(substituerad tio sulfinyl eller sulfonyl)imida zoderivat

Country Status (26)

Country Link
JP (1) JPS53130664A (el)
AR (1) AR219310A1 (el)
AT (1) AT361470B (el)
AU (1) AU517028B2 (el)
CA (1) CA1105024A (el)
CH (1) CH644108A5 (el)
DE (1) DE2805167A1 (el)
DK (1) DK16778A (el)
ES (1) ES466794A1 (el)
FI (1) FI69462C (el)
FR (1) FR2380275A1 (el)
GB (1) GB1564184A (el)
GR (1) GR64142B (el)
HU (1) HU178211B (el)
IE (1) IE46187B1 (el)
IL (1) IL53995A (el)
IT (1) IT1092588B (el)
LU (1) LU79024A1 (el)
MX (1) MX5933E (el)
NL (1) NL7801453A (el)
NO (1) NO148265C (el)
NZ (1) NZ186410A (el)
PH (1) PH13852A (el)
PT (1) PT67626B (el)
SE (1) SE7801467L (el)
YU (1) YU28878A (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1302A (en) * 1978-04-11 1985-12-06 Ciba Geigy Ag Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (da) * 1978-10-02 1980-04-03 Du Pont Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler
AT374198B (de) * 1979-04-10 1984-03-26 Ciba Geigy Ag Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate, ihrer n-oxyde und ihrer salze
FI850995L (fi) * 1984-03-16 1985-09-17 Ciba Geigy Ag Foerfarande foer framstaellning av nya 3-merkapto-1,2,4-triazacykloalkadienderivat.
EP0994858A1 (en) * 1997-06-30 2000-04-26 Ortho-McNeil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (el) * 1972-07-29 1978-11-24
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler

Also Published As

Publication number Publication date
YU28878A (en) 1983-01-21
AU517028B2 (en) 1981-07-02
IT7820078A0 (it) 1978-02-07
NO780433L (no) 1978-08-10
FI780428A (fi) 1978-08-10
IE46187B1 (en) 1983-03-23
PT67626B (en) 1979-07-17
AT361470B (de) 1981-03-10
NO148265B (no) 1983-05-30
DE2805167A1 (de) 1978-08-10
NL7801453A (nl) 1978-08-11
FI69462B (fi) 1985-10-31
ATA86978A (de) 1980-08-15
IL53995A (en) 1982-02-28
SE7801467L (sv) 1978-08-10
JPS53130664A (en) 1978-11-14
FR2380275B1 (el) 1982-01-08
GB1564184A (en) 1980-04-02
LU79024A1 (fr) 1979-05-25
GR64142B (en) 1980-01-28
IL53995A0 (en) 1978-04-30
CH644108A5 (en) 1984-07-13
FR2380275A1 (fr) 1978-09-08
ES466794A1 (es) 1979-08-01
HU178211B (en) 1982-03-28
NO148265C (no) 1983-09-07
DK16778A (da) 1978-08-10
PT67626A (en) 1978-03-01
NZ186410A (en) 1979-12-11
AR219310A1 (es) 1980-08-15
PH13852A (en) 1980-10-22
IE780279L (en) 1978-08-09
CA1105024A (en) 1981-07-14
MX5933E (es) 1984-08-30
AU3309678A (en) 1979-08-16
IT1092588B (it) 1985-07-12

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: E.I. DU PONT DE NEMOURS AND CO