FI69461C - Analogifoerfarande foer framstaellning av nya saosom laekemedelsaktivaemnen anvaendbara bensotiofen-2-on-3-karboxamider - Google Patents
Analogifoerfarande foer framstaellning av nya saosom laekemedelsaktivaemnen anvaendbara bensotiofen-2-on-3-karboxamider Download PDFInfo
- Publication number
- FI69461C FI69461C FI771044A FI771044A FI69461C FI 69461 C FI69461 C FI 69461C FI 771044 A FI771044 A FI 771044A FI 771044 A FI771044 A FI 771044A FI 69461 C FI69461 C FI 69461C
- Authority
- FI
- Finland
- Prior art keywords
- benzo
- oxo
- formula
- dihydro
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (2)
1. Analogiförfarande för framställning av nya, sasom läkemedels-aktivämnen användbara bensotiofen-2-on-3-karboxamider med formeln II 23 68461 i'phS—r$-NH-Ri m , W'° i vilken 1,2-fenylenringen Ph eventuellt är ytterligare substituerad med klor, lägalkoxi eller nitro och betecknar lagalkyl, eventuellt raed fluor, klor, brom, lägalkoxi, lagalkyl, trifluorimetyl eller lag-alkoxikarbony1 substituerad fenyl, eventuellt med halogen substitue-rad pyridyl, tiazolyl, eller med lagalkyl substituerad isoxazo-lyl, sarat salter därav, vilka även kan föreligga i den motsvaran-de tautomera 2-hydroksibenso(b)tiofen-formen, kännetecknat därav, att a) en bensotiofen-2-on-förening med formeln * Ph H 9Hf2, (II) ·. · · =0 V v omsättes med en förening med formeln
0. C - N (III) *o ^R°2 i vilken Rq betecknar en företrad eller förestrad hydroxigrupp eller en eventuellt substituerad aminogrupp, och R° betecknar väte, eller i vilken Rq och R^ tillsammans bildar en bindning, eller b) förening med formeln v v i vilken R* betecknar en företrad eller förestrad hydroxigrupp, omsättes med en amin med formeln R^-NH2 (V), eller c) en förening med formeln
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH453876 | 1976-04-09 | ||
| CH453876A CH630082A5 (de) | 1976-04-09 | 1976-04-09 | Verfahren zur herstellung von oxothiaverbindungen. |
| CH1599476A CH629797A5 (en) | 1976-12-20 | 1976-12-20 | Process for the preparation of salts of oxothia compounds |
| CH1599476 | 1976-12-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771044A FI771044A (sv) | 1977-10-10 |
| FI69461B FI69461B (fi) | 1985-10-31 |
| FI69461C true FI69461C (fi) | 1986-02-10 |
Family
ID=25695718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771044A FI69461C (fi) | 1976-04-09 | 1977-04-04 | Analogifoerfarande foer framstaellning av nya saosom laekemedelsaktivaemnen anvaendbara bensotiofen-2-on-3-karboxamider |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4320138A (sv) |
| JP (1) | JPS52125158A (sv) |
| AR (3) | AR218869A1 (sv) |
| AT (1) | AT357148B (sv) |
| CA (1) | CA1112248A (sv) |
| CS (4) | CS207395B2 (sv) |
| CY (1) | CY1138A (sv) |
| DD (1) | DD130659A5 (sv) |
| DE (1) | DE2713584C2 (sv) |
| DK (1) | DK152046C (sv) |
| ES (1) | ES457528A1 (sv) |
| FI (1) | FI69461C (sv) |
| FR (1) | FR2347363A1 (sv) |
| GB (1) | GB1544339A (sv) |
| GR (1) | GR70652B (sv) |
| HK (1) | HK6182A (sv) |
| HU (1) | HU180438B (sv) |
| IE (1) | IE44987B1 (sv) |
| IL (1) | IL51847A (sv) |
| KE (1) | KE3185A (sv) |
| MY (1) | MY8200244A (sv) |
| NL (1) | NL7703802A (sv) |
| NO (1) | NO146810C (sv) |
| NZ (1) | NZ183747A (sv) |
| PL (3) | PL111459B1 (sv) |
| SE (1) | SE432930B (sv) |
| SU (4) | SU795475A3 (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH634840A5 (de) * | 1978-06-29 | 1983-02-28 | Ciba Geigy Ag | 2-oxo-2,3-dihydro-benzo(b)thiophen-verbindung und daraus hergestellte pharmazeutische praeparate. |
| AT392787B (de) * | 1978-06-29 | 1991-06-10 | Ciba Geigy Ag | Verfahren zur herstellung des neuen n-(2-thienyl)-2-oxo-2,3-dihydro-benzo(b)thiophen-3-carboxamids |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3413308A (en) * | 1966-09-02 | 1968-11-26 | Dow Chemical Co | Substituted benzo(b)thiophene-2-carboxanilides |
| US3655693A (en) * | 1969-06-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory salicyclic acid derivatives |
| US3676463A (en) * | 1970-10-15 | 1972-07-11 | Pfizer | Oxobenzofuran carboxamides |
| US3971814A (en) * | 1972-11-27 | 1976-07-27 | Warner-Lambert Company | Benzo(b)thiophene derivatives |
| GB1571847A (en) * | 1974-01-02 | 1980-07-23 | Systems Eng & Mfg | Waste water treatment |
-
1977
- 1977-03-28 DE DE2713584A patent/DE2713584C2/de not_active Expired
- 1977-03-31 NZ NZ183747A patent/NZ183747A/xx unknown
- 1977-04-01 GB GB13857/77A patent/GB1544339A/en not_active Expired
- 1977-04-01 CY CY1138A patent/CY1138A/xx unknown
- 1977-04-04 FI FI771044A patent/FI69461C/fi not_active IP Right Cessation
- 1977-04-05 ES ES457528A patent/ES457528A1/es not_active Expired
- 1977-04-06 SU SU772468109A patent/SU795475A3/ru active
- 1977-04-06 NO NO771231A patent/NO146810C/no unknown
- 1977-04-06 GR GR53186A patent/GR70652B/el unknown
- 1977-04-06 NL NL7703802A patent/NL7703802A/xx not_active Application Discontinuation
- 1977-04-06 SE SE7704033A patent/SE432930B/sv not_active IP Right Cessation
- 1977-04-06 DK DK158777A patent/DK152046C/da not_active IP Right Cessation
- 1977-04-07 CS CS772337A patent/CS207395B2/cs unknown
- 1977-04-07 DD DD7700198312A patent/DD130659A5/xx unknown
- 1977-04-07 FR FR7710590A patent/FR2347363A1/fr active Granted
- 1977-04-07 IE IE741/77A patent/IE44987B1/en not_active IP Right Cessation
- 1977-04-07 CS CS772337A patent/CS207392B2/cs unknown
- 1977-04-07 CS CS772337A patent/CS207394B2/cs unknown
- 1977-04-07 CS CS772337A patent/CS207393B2/cs unknown
- 1977-04-07 CA CA275,837A patent/CA1112248A/en not_active Expired
- 1977-04-08 IL IL51847A patent/IL51847A/xx unknown
- 1977-04-08 HU HU77CI1728A patent/HU180438B/hu unknown
- 1977-04-08 PL PL1977204751A patent/PL111459B1/pl unknown
- 1977-04-08 PL PL1977204750A patent/PL111456B1/pl unknown
- 1977-04-08 PL PL1977197311A patent/PL110653B1/pl unknown
- 1977-04-08 AT AT248577A patent/AT357148B/de not_active IP Right Cessation
- 1977-04-09 JP JP3998877A patent/JPS52125158A/ja active Granted
- 1977-04-11 AR AR267166A patent/AR218869A1/es active
-
1978
- 1978-02-06 SU SU782468109D patent/SU898956A3/ru active
- 1978-02-08 SU SU782576952A patent/SU791239A3/ru active
- 1978-02-14 AR AR271100A patent/AR224614A1/es active
- 1978-02-14 AR AR271101A patent/AR225401A1/es active
- 1978-05-11 SU SU782612600A patent/SU738510A3/ru active
-
1980
- 1980-12-08 US US06/214,168 patent/US4320138A/en not_active Expired - Lifetime
-
1982
- 1982-02-08 KE KE3185A patent/KE3185A/xx unknown
- 1982-02-11 HK HK61/82A patent/HK6182A/xx unknown
- 1982-12-30 MY MY244/82A patent/MY8200244A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: CIBA-GEIGY AG |