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FI67231C - Foerfarande foer framstaellning av en hypokolesteremisk foerening - Google Patents

Foerfarande foer framstaellning av en hypokolesteremisk foerening Download PDF

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Publication number
FI67231C
FI67231C FI801857A FI801857A FI67231C FI 67231 C FI67231 C FI 67231C FI 801857 A FI801857 A FI 801857A FI 801857 A FI801857 A FI 801857A FI 67231 C FI67231 C FI 67231C
Authority
FI
Finland
Prior art keywords
culture
solution
compound
flask
hours
Prior art date
Application number
FI801857A
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English (en)
Finnish (fi)
Other versions
FI67231B (fi
FI801857A (fi
Inventor
Richard L Monaghan
Alfred W Alberts
Carl H Hoffman
George Albers-Schonberg
Henry Joshua
Maria B Lopez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI67231(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/048,946 external-priority patent/US4231938A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI801857A publication Critical patent/FI801857A/fi
Publication of FI67231B publication Critical patent/FI67231B/fi
Application granted granted Critical
Publication of FI67231C publication Critical patent/FI67231C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (5)

1. Förfarande för framställning av en hypokolesteremisk förening med formeIn Q J “· ι^ΐ f CH3 CH3 där vid den streckade linjen kan finnas en enkel bindning eller en dubbelbindning, och Q är ΗΟγ-γ° _ eller OH V V kännetecknat därav, att man i ett odlingsmedium odlar en mlkroorganlsm av släktet Aspergillus terreus, och föreningen isoleras ur odlingsmediet.
2. Förfarande enligt patentkravet 1 för framställning av en förening med formeIn 67231 31 ΗΟγ^γ° -λ y ΓΗ ^ 0 f
3. Förfarande enligt patentkravet 2, kännetecknat därav, att den använda mikroorganismens deponeringsnummer är ATCC 20541 eller 20542.
3. I Λγ\- ’ ch3 kännetecknat därav, att man i ett odlingsmedium odlar en mikroorganism av släktet Aspergillus terreus, och föreningen iso-leras ur odlingsmediet.
4. Förfarande enligt patentkravet 1 för framställning av en förening med formeln H0v _ 0 OH L\C)H ΐ f kännetecknat därav, att man i ett odlingsmedium odlar en mikroorganism av släktet Aspergillus terreus, och föreningen isoleras ur odlingsmediet.
5. Förfarande enligt patentkravet 4, kännetecknat därav, att man använder en mikroorganism med deponerings-numret ATCC 20541 eller 20542.
FI801857A 1979-06-15 1980-06-10 Foerfarande foer framstaellning av en hypokolesteremisk foerening FI67231C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US4894679 1979-06-15
US06/048,946 US4231938A (en) 1979-06-15 1979-06-15 Hypocholesteremic fermentation products and process of preparation
US7780779A 1979-09-21 1979-09-21
US7780779 1979-09-21
US11445980A 1980-01-23 1980-01-23
US11445980 1980-01-23

Publications (3)

Publication Number Publication Date
FI801857A FI801857A (fi) 1980-12-16
FI67231B FI67231B (fi) 1984-10-31
FI67231C true FI67231C (fi) 1985-02-11

Family

ID=27367450

Family Applications (1)

Application Number Title Priority Date Filing Date
FI801857A FI67231C (fi) 1979-06-15 1980-06-10 Foerfarande foer framstaellning av en hypokolesteremisk foerening

Country Status (20)

Country Link
EP (1) EP0022478B1 (sv)
AR (1) AR224008A1 (sv)
AT (1) ATE2620T1 (sv)
AU (1) AU535944B2 (sv)
CA (1) CA1161380A (sv)
DD (1) DD157344A5 (sv)
DE (1) DE3062122D1 (sv)
DK (1) DK149003C (sv)
EG (1) EG16957A (sv)
ES (1) ES492384A0 (sv)
FI (1) FI67231C (sv)
GR (1) GR69216B (sv)
IE (1) IE49685B1 (sv)
IL (1) IL60219A (sv)
NO (1) NO155699C (sv)
NZ (1) NZ193922A (sv)
PL (1) PL125843B1 (sv)
PT (1) PT71371B (sv)
RO (1) RO79487A (sv)
ZW (1) ZW13480A1 (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
DE8533814U1 (de) * 1985-11-30 1986-01-16 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Spülen des Darmes
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
AU618158B2 (en) * 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (sv) 1989-07-21 1995-08-25 Warner Lambert Co Förfarande för framställning av farmaceutiskt användbar /R-(R*,R*)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav
CA2062023A1 (en) 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
HUP9601808A3 (en) * 1995-07-03 2000-06-28 Sankyo Co Treatment of arteriosclerosis and xanthoma
CN1171400A (zh) 1996-03-05 1998-01-28 武田药品工业株式会社 呫吨衍生物,其制备和用途
ES2262228T3 (es) * 1997-02-20 2006-11-16 Dsm Ip Assets B.V. Produccion fermentativa de compuestos valiosos a escala industrial empleando medios quimicamente definidos.
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CN101484166B (zh) 2006-07-05 2012-09-05 奈科明有限责任公司 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Also Published As

Publication number Publication date
ATE2620T1 (de) 1983-03-15
AR224008A1 (es) 1981-10-15
ES8105389A1 (es) 1981-06-01
NO155699B (no) 1987-02-02
AU535944B2 (en) 1984-04-12
PL125843B1 (en) 1983-06-30
CA1161380A (en) 1984-01-31
DK254180A (da) 1980-12-16
FI67231B (fi) 1984-10-31
EG16957A (en) 1990-06-30
DK149003C (da) 1986-08-18
IL60219A (en) 1985-05-31
NO801775L (no) 1980-12-16
DE3062122D1 (en) 1983-03-31
IE801232L (en) 1980-12-15
EP0022478B1 (en) 1983-02-23
RO79487A (ro) 1982-07-06
AU5901780A (en) 1980-12-18
PL224920A1 (sv) 1981-03-27
DK149003B (da) 1985-12-16
NZ193922A (en) 1982-05-25
GR69216B (sv) 1982-05-07
EP0022478A1 (en) 1981-01-21
DD157344A5 (de) 1982-11-03
IL60219A0 (en) 1980-09-16
NO155699C (no) 1987-05-13
IE49685B1 (en) 1985-11-27
FI801857A (fi) 1980-12-16
PT71371B (en) 1981-10-21
ES492384A0 (es) 1981-06-01
ZW13480A1 (en) 1982-02-03
PT71371A (en) 1980-07-01

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Legal Events

Date Code Title Description
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L1

Extension date: 20030622

MA Patent expired

Owner name: MERCK & CO INC.