FI62666C - Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav Download PDF

Info

Publication number: FI62666C
Authority: FI; Finland
Prior art keywords: formula; chloro; compound; piperazinyl; pyrazine
Prior art date: 1975-04-21

Application number

FI760978A

Other languages

English (en)

Finnish (fi)

Other versions

FI62666B (fi

FI760978A (ro

Inventor

Walfred Spencer Saari

Jr William Carl Lumma

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-09

Publication date

1983-02-10

1976-04-09 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1976-10-22 Publication of FI760978A publication Critical patent/FI760978A/fi

1982-10-29 Publication of FI62666B publication Critical patent/FI62666B/fi

1983-02-10 Application granted granted Critical

1983-02-10 Publication of FI62666C publication Critical patent/FI62666C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI760978A 1975-04-21 1976-04-09 Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav FI62666C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21
US57005275		1975-04-21

Publications (3)

Publication Number	Publication Date
FI760978A FI760978A (ro)	1976-10-22
FI62666B FI62666B (fi)	1982-10-29
FI62666C true FI62666C (fi)	1983-02-10

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI760978A FI62666C (fi)	1975-04-21	1976-04-09	Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav

Country Status (36)

Country	Link
JP (1)	JPS51136688A (ro)
AR (1)	AR210349A1 (ro)
AT (1)	AT353795B (ro)
AU (1)	AU496854B2 (ro)
BE (1)	BE840904A (ro)
BG (1)	BG34185A3 (ro)
CA (1)	CA1059128A (ro)
CH (1)	CH619462A5 (ro)
CS (1)	CS195726B2 (ro)
CY (1)	CY1090A (ro)
DD (1)	DD124599A5 (ro)
DE (1)	DE2617205C3 (ro)
DK (1)	DK143899C (ro)
EG (1)	EG12387A (ro)
ES (4)	ES447150A1 (ro)
FI (1)	FI62666C (ro)
FR (1)	FR2308367A1 (ro)
GB (1)	GB1492528A (ro)
GR (1)	GR59900B (ro)
HK (1)	HK60380A (ro)
HU (1)	HU172684B (ro)
IE (1)	IE42979B1 (ro)
IL (1)	IL49391A (ro)
KE (1)	KE3088A (ro)
LU (1)	LU74795A1 (ro)
MY (1)	MY8100225A (ro)
NL (1)	NL167692C (ro)
NO (1)	NO146599C (ro)
PH (1)	PH12274A (ro)
PL (1)	PL99664B1 (ro)
PT (1)	PT65027B (ro)
RO (1)	RO73278A (ro)
SE (1)	SE421695B (ro)
SU (1)	SU638260A3 (ro)
YU (1)	YU100676A (ro)
ZA (1)	ZA762320B (ro)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
BR9813279B1 (pt) *	1997-10-27	2010-11-16		derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina.
AU773830B2 (en)	1999-04-26	2004-06-10	Neurosearch A/S	Heteroaryl diazacycloalkanes, their preparation and use
US6995161B2 (en) *	2000-02-16	2006-02-07	Neurogen Corporation	Substituted arylpyrazines
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
KR20050025628A (ko) *	2002-07-19	2005-03-14	바이오비트럼 에이비	5-ｈｔ2ａ 수용체 관련 장애의 치료를 위한 신규피페라지닐-피라지논 유도체
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
1977
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
DE2617205A1 (de)	1976-10-28
IE42979L (en)	1976-10-21
AR210349A1 (es)	1977-07-29
ZA762320B (en)	1977-11-30
YU100676A (en)	1982-08-31
CS195726B2 (en)	1980-02-29
DK143899B (da)	1981-10-26
DK143899C (da)	1982-04-13
FI62666B (fi)	1982-10-29
AT353795B (de)	1979-12-10
ES459406A1 (es)	1978-08-16
DK164476A (da)	1976-10-22
FR2308367A1 (fr)	1976-11-19
NO761207L (ro)	1976-10-22
NO146599C (no)	1982-11-03
ES447150A1 (es)	1977-09-16
JPS5522475B2 (ro)	1980-06-17
DE2617205B2 (de)	1980-05-08
PH12274A (en)	1978-12-12
PT65027A (en)	1976-05-01
CY1090A (en)	1980-12-27
SE7604093L (sv)	1976-10-22
BE840904A (fr)	1976-08-16
FI760978A (ro)	1976-10-22
AU1296676A (en)	1977-10-20
GR59900B (en)	1978-03-16
IE42979B1 (en)	1980-11-19
GB1492528A (en)	1977-11-23
HK60380A (en)	1980-11-07
IL49391A (en)	1979-09-30
AU496854B2 (en)	1978-11-02
FR2308367B1 (ro)	1979-09-21
ATA288376A (de)	1979-05-15
JPS51136688A (en)	1976-11-26
NL7603800A (nl)	1976-10-25
NL167692B (nl)	1981-08-17
IL49391A0 (en)	1976-06-30
CA1059128A (en)	1979-07-24
EG12387A (en)	1978-12-31
HU172684B (hu)	1978-11-28
SE421695B (sv)	1982-01-25
BG34185A3 (en)	1983-07-15
KE3088A (en)	1980-11-07
DE2617205C3 (de)	1981-01-29
ES459407A1 (es)	1978-08-16
MY8100225A (en)	1981-12-31
ES459405A1 (es)	1978-08-16
NO146599B (no)	1982-07-26
LU74795A1 (ro)	1977-02-07
RO73278A (ro)	1982-09-09
PT65027B (en)	1978-04-03
DD124599A5 (ro)	1977-03-02
SU638260A3 (ru)	1978-12-15
PL99664B1 (pl)	1978-07-31
CH619462A5 (en)	1980-09-30
NL167692C (nl)	1982-01-18

Similar Documents

Publication	Publication Date	Title
FI62666C (fi)	1983-02-10	Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav
US7579365B2 (en)	2009-08-25	Indolyl-3-glyoxylic acid derivatives having antitumor action
US3696197A (en)	1972-10-03	Pharmaceutical compositions containing homopyrimidazole derivatives
EP0079545B1 (en)	1986-05-21	Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
HU184989B (en)	1987-06-30	Process for preparing derivatives of 2-/4-/diphenyl-methyl/-piperazin-1-yl/-acetic acid
HU211256A9 (en)	1995-11-28	New benzimidazolone derivatives
JPH0735371B2 (ja)	1995-04-19	新規なオキサゾロピリジン誘導体、これらの製造法およびそれらを含む製薬組成物
JP2002504103A (ja)	2002-02-05	３−置換された３、４−ジヒドロチエノ［２、３−ｄ］ピリミジン誘導体
US3944551A (en)	1976-03-16	N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines
HU190635B (en)	1986-09-29	Process for preparing benzoxazoline-derivatives and the pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions comprising the same as active substance
FI94953B (fi)	1995-08-15	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
LV10716B (en)	1995-12-20	Novel derivatives of triazolopyridine and triazoloquinoline aminoalkylthio compounds, methods for preparation thereof, medicinal preparations containing same, their use as analgetics
HU201057B (en)	1990-09-28	Process for producing 6-phenyl-3-(piperazinyl-alkyl)-1h,3h-pyrimidin-2,4-dion derivatives and pharmaceutical compositions containing them
FI77456C (fi)	1989-03-10	Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/2-/4-(2-metoxifenyl) -1-piperazinyl/etyl/-2,4-(1h,3h)-kinazolindionderivat.
IE840682L (en)	1984-09-21	Bis(piperazinyl or homopiperazinyl) alkanes
US4065451A (en)	1977-12-27	1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts
ES2215312T3 (es)	2004-10-01	Derivados de pirido(3',4':4,5)tieno(2,3-d)-pirimidina 3-substituidos, su obtencion y empleo.
US4022779A (en)	1977-05-10	Amino derivatives of pyrido(3,4-b)pyrazine carboxylic acids and esters
EP3277687B1 (en)	2019-10-30	7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer
CN110950807B (zh)	2023-03-03	联芳基类化合物、其制备方法、药物组合物及其应用
JPH1017555A (ja)	1998-01-20	６−アミノ−５−メチルウラシル誘導体
KR790001500B1 (ko)	1979-10-24	피페라지닐 피라진 화합물의 제법
US3838122A (en)	1974-09-24	2-heterocyclic-1,3-benzodiazepines
FI82048B (fi)	1990-09-28	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetraoxo-3,7-diazabicyklo (3,3,1)- nonanderivat.
CN106957303A (zh)	2017-07-18	选择性AuroraA激酶抑制活性的喹唑啉衍生物及其制备方法以及应用

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: MERCK & CO INC.