FI62301C - Analogifoerfarande foer framstaellning av farmakologiskt aktiva imidazolderivat - Google Patents

Analogifoerfarande foer framstaellning av farmakologiskt aktiva imidazolderivat Download PDF

Info

Publication number: FI62301C
Authority: FI; Finland
Prior art keywords: methyl; imidazolylmethylthio; ethylamino; pyrimidone; lower alkyl
Prior art date: 1973-05-03

Application number

FI1261/74A

Other languages

English (en)

Finnish (fi)

Other versions

FI62301B (fi

Inventor

Graham John Durant

John Colin Emmett

Charon Robin Ganellin

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-05-03

Filing date

1974-04-24

Publication date

1982-12-10

1974-04-24 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1982-08-31 Publication of FI62301B publication Critical patent/FI62301B/fi

1982-12-10 Application granted granted Critical

1982-12-10 Publication of FI62301C publication Critical patent/FI62301C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FI1261/74A 1973-05-03 1974-04-24 Analogifoerfarande foer framstaellning av farmakologiskt aktiva imidazolderivat FI62301C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB2106373		1973-05-03
GB2106373A GB1419994A (en)	1973-05-03	1973-05-03	Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
GB3555173		1973-07-26
GB3555173		1973-07-26

Publications (2)

Publication Number	Publication Date
FI62301B FI62301B (fi)	1982-08-31
FI62301C true FI62301C (fi)	1982-12-10

Family

ID=26255089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI1261/74A FI62301C (fi)	1973-05-03	1974-04-24	Analogifoerfarande foer framstaellning av farmakologiskt aktiva imidazolderivat

Country Status (18)

Country	Link
US (1)	US3932644A (sv)
JP (1)	JPS5855145B2 (sv)
AU (1)	AU477220B2 (sv)
BE (1)	BE814032A (sv)
CA (1)	CA1041108A (sv)
CH (1)	CH605917A5 (sv)
DE (1)	DE2421548A1 (sv)
ES (1)	ES425936A1 (sv)
FI (1)	FI62301C (sv)
FR (1)	FR2227869B1 (sv)
GB (1)	GB1419994A (sv)
HU (1)	HU168863B (sv)
IE (1)	IE40014B1 (sv)
IL (1)	IL44526A (sv)
IN (1)	IN138721B (sv)
NL (1)	NL7404811A (sv)
SE (1)	SE416299B (sv)
SU (1)	SU719500A3 (sv)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4578459A (en) *	1973-05-03	1986-03-25	Smithkline & French Laboratories Limited	Heterocyclic alkylaminoheterocycles
JPS5239976U (sv) *	1975-09-12	1977-03-22
US4145546A (en)	1975-10-02	1979-03-20	Smith Kline & French Laboratories Limited	4-Pyrimidone compounds
IN146736B (sv) *	1975-10-02	1979-08-25	Smith Kline French Lab
US4218452A (en)	1975-10-02	1980-08-19	Smith Kline & French Laboratories Limited	Substituted 4-pyrimidone compounds, compositions and methods of use
US4216318A (en) *	1975-12-29	1980-08-05	Smith Kline & French Laboratories Limited	Heterocyclic alkyl 4-pyrimidones
MW5076A1 (en) *	1975-12-29	1978-02-08	Smith Kline French Lab	Pharmacologicalle active compounds
US4378365A (en) *	1976-05-14	1983-03-29	Smith Kline & French Laboratories Limited	Pharmaceutical compositions
US4649138A (en) *	1976-05-14	1987-03-10	Smithkline & French Laboratories Limited	Pharmaceutical compositions
NZ186511A (en) *	1977-03-19	1980-11-14	Smith Kline French Lab	3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
US4165378A (en)	1977-04-20	1979-08-21	Ici Americas Inc.	Guanidine derivatives of imidazoles and thiazoles
ZA782129B (en)	1977-04-20	1979-03-28	Ici Ltd	Hertocyclic derivatives
US4539207A (en) *	1978-02-13	1985-09-03	Smith Kline & French Laboratories Limited	Pyrimidine compounds
IN151188B (sv) *	1978-02-13	1983-03-05	Smith Kline French Lab
IL57005A (en) *	1978-04-11	1983-11-30	Smith Kline French Lab	Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
AR228941A1 (es)	1978-04-26	1983-05-13	Glaxo Group Ltd	Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
ATE1353T1 (de)	1978-05-24	1982-08-15	Imperial Chemical Industries Plc	Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4584384A (en) *	1978-05-30	1986-04-22	Smith Kline & French Laboratories Limited	Nitro pyrroles
IL57415A (en) *	1978-05-30	1984-08-31	Smith Kline French Lab	Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
ZA792607B (en) *	1978-05-30	1980-07-30	Smith Kline French Lab	Nitro compounds
IL57416A (en) *	1978-05-30	1983-03-31	Smith Kline French Lab	Nitro compounds,processes for preparing them and compositions containing them
ZA793392B (en) *	1978-07-15	1980-08-27	Smith Kline French Lab	Isoureas and isothioureas
ZA793443B (en) *	1978-07-26	1980-12-31	Glaxo Group Ltd	Heterocyclic derivatives
US4374836A (en)	1978-10-16	1983-02-22	Imperial Chemical Industries Ltd.	Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4496567A (en) *	1978-11-13	1985-01-29	Smith Kline & French Laboratories Limited	Phenyl alkylaminopyrimidones
US4521418A (en) *	1979-02-21	1985-06-04	Smith Kline & French Laboratories Limited	Guanidinothiazolyl derivatives
US4256743A (en) *	1979-02-22	1981-03-17	President And Fellows Of Harvard College	Inhibition of bone resorption with H1 -blocking antihistamines
JPS55120571A (en) *	1979-03-02	1980-09-17	Glaxo Group Ltd	Heterocyclic derivative
ZA801151B (en) *	1979-03-02	1981-02-25	Glaxo Group Ltd	Heterocyclic derivatives
AU531142B2 (en) *	1979-04-04	1983-08-11	Smith Kline & French Laboratories Limited	2 amino- pyimindones
DE3067564D1 (en) *	1979-10-22	1984-05-24	Glaxo Group Ltd	1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL61233A (en) *	1979-10-24	1984-08-31	Smith Kline French Lab	Guanidino thiazolylalkylamino(alkylthioalkylamino)nitro pyrroles,process for their preparation and pharmaceutical compositions containing them
IL61234A (en) *	1979-10-24	1984-03-30	Smith Kline French Lab	Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them
CH655104A5 (fr) *	1980-02-28	1986-03-27	Glaxo Group Ltd	Derives heterocycliques triazoliques, procedes pour leur preparation et compositions pharmaceutiques les comportant.
US4439609A (en) *	1980-10-01	1984-03-27	Smith Kline & French Laboratories Limited	Pyridines
ZW21281A1 (en) *	1980-10-01	1981-11-18	Smith Kline French Lab	Amine derivatives
US4352933A (en) *	1981-02-06	1982-10-05	Smithkline Beckman Corporation	Chemical methods and intermediates for preparing substituted pyrimidinones
US4439437A (en) *	1981-04-28	1984-03-27	Smith Kline & French Laboratories Limited	2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or butyl)amino]-3-(hydroxy or carboxy)pyridines, compositions containing same and method of use
IE53068B1 (en) *	1981-06-15	1988-05-25	Merck & Co Inc	Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
US4525477A (en) *	1981-12-02	1985-06-25	Smith Kline & French Laboratories Limited	2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
EP0102026A3 (en) *	1982-08-20	1984-05-16	Hoechst Uk Limited	Thiazole derivatives
EP0104611A3 (en) *	1982-09-28	1985-06-12	Hoechst Uk Limited	Thiatriazine derivatives
JO1275B1 (en) *	1982-12-03	1985-04-20	هنري براون ثوماس	Chemical process
AU2222083A (en) *	1982-12-14	1984-06-21	Smith Kline & French Laboratories Limited	Pyridine derivatives
EP0112704B1 (en) *	1982-12-23	1987-10-07	Smith Kline & French Laboratories Limited	Pyridine derivatives
PT77856B (en) *	1982-12-23	1986-04-16	Smith Kline French Lab	Pyridine derivatives
GB8311443D0 (en) *	1983-04-27	1983-06-02	Smith Kline French Lab	Chemical compounds
GB8318638D0 (en) *	1983-07-09	1983-08-10	Smith Kline French Lab	Chemical compounds
GB8328907D0 (en) *	1983-10-28	1983-11-30	Smith Kline French Lab	Chemical compounds
GB8332091D0 (en) *	1983-12-01	1984-01-11	Smith Kline French Lab	Chemical compounds
GB2344588B (en) *	1997-07-25	2001-11-14	Black James Foundation	1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
GB9715814D0 (en)	1997-07-25	1997-10-01	Black James Foundation	Histamine H3 receptor ligands
EP4196793A1 (en)	2020-08-11	2023-06-21	Université de Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE758759A (fr) *	1969-11-12	1971-05-10	Merck & Co Inc	Pyridones anti-inflammatoires
US3853897A (en) *	1971-07-16	1974-12-10	Merck & Co Inc	Certain 1-substituted-3-amino-1(2h)pyridones

1973
- 1973-05-03 GB GB2106373A patent/GB1419994A/en not_active Expired
1974
- 1974-03-26 IN IN664/CAL/74A patent/IN138721B/en unknown
- 1974-03-29 IL IL7444526A patent/IL44526A/xx unknown
- 1974-04-09 NL NL7404811A patent/NL7404811A/xx not_active Application Discontinuation
- 1974-04-09 CA CA197,225A patent/CA1041108A/en not_active Expired
- 1974-04-22 BE BE143479A patent/BE814032A/xx not_active IP Right Cessation
- 1974-04-24 FI FI1261/74A patent/FI62301C/fi active
- 1974-04-24 US US05/463,647 patent/US3932644A/en not_active Expired - Lifetime
- 1974-04-29 SE SE7405732A patent/SE416299B/sv unknown
- 1974-04-30 SU SU742021439A patent/SU719500A3/ru active
- 1974-04-30 FR FR7415085A patent/FR2227869B1/fr not_active Expired
- 1974-04-30 JP JP49049242A patent/JPS5855145B2/ja not_active Expired
- 1974-05-02 HU HUSI1399A patent/HU168863B/hu unknown
- 1974-05-02 CH CH600174A patent/CH605917A5/xx not_active IP Right Cessation
- 1974-05-03 ES ES74425936A patent/ES425936A1/es not_active Expired
- 1974-05-03 IE IE949/74A patent/IE40014B1/xx unknown
- 1974-05-03 DE DE2421548A patent/DE2421548A1/de not_active Withdrawn
- 1974-05-03 AU AU68598/74A patent/AU477220B2/en not_active Expired

Also Published As

Publication number	Publication date
US3932644A (en)	1976-01-13
DE2421548A1 (de)	1974-11-21
CH605917A5 (sv)	1978-10-13
BE814032A (fr)	1974-10-22
AU6859874A (en)	1975-11-06
NL7404811A (sv)	1974-11-05
IL44526A0 (en)	1974-06-30
JPS5025565A (sv)	1975-03-18
IN138721B (sv)	1976-03-20
IE40014B1 (en)	1979-02-28
GB1419994A (en)	1976-01-07
FR2227869A1 (sv)	1974-11-29
ES425936A1 (es)	1976-09-16
HU168863B (sv)	1976-07-28
JPS5855145B2 (ja)	1983-12-08
FI62301B (fi)	1982-08-31
IE40014L (en)	1974-11-03
SU719500A3 (ru)	1980-02-29
AU477220B2 (en)	1976-10-21
IL44526A (en)	1979-05-31
SE416299B (sv)	1980-12-15
CA1041108A (en)	1978-10-24
FR2227869B1 (sv)	1978-07-21

Publication	Publication Date	Title
FI62301C (fi)	1982-12-10	Analogifoerfarande foer framstaellning av farmakologiskt aktiva imidazolderivat
IE59309B1 (en)	1994-02-09	New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them
WO1997020821A1 (en)	1997-06-12	Heteroaryl derivatives
WO1997020822A1 (en)	1997-06-12	Quinazolin-2,4-diazirines as npy receptor antagonist
CA1334199C (en)	1995-01-31	Dopamine beta hydroxylase inhibitors
HU193275B (en)	1987-09-28	Process for production of derivatives of dihydripirizin and medical preparatives containing thereof
US4005205A (en)	1977-01-25	Compositions and methods for inhibiting H2 histamine receptors
CZ284757B6 (cs)	1999-02-17	Nové deriváty triazolpyrimidinu, způsob jejich přípravy a farmaceutické směsi je obsahující
EP0077983A1 (en)	1983-05-04	Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
EP0122494A2 (en)	1984-10-24	Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
US4104381A (en)	1978-08-01	Pharmacologically active compounds
US4399142A (en)	1983-08-16	Pharmacologically active compounds
US4153793A (en)	1979-05-08	Imidazo alkylamino pyrimidones
NZ202974A (en)	1985-01-31	Benzodioxine derivatives and pharmaceutical compositions
US4181730A (en)	1980-01-01	Pharmacologically active compounds as inhibitors of H-2 histamine receptors
WO2020167952A1 (en)	2020-08-20	Mat2a inhibitors
US4035374A (en)	1977-07-12	Imidazolyl alkylaminopyridone and pyridinethione compounds
US4260744A (en)	1981-04-07	Pharmacologically active compounds
US4341787A (en)	1982-07-27	Pharmacologically active compounds
US4467087A (en)	1984-08-21	1,2,4-Triazines
US4578459A (en)	1986-03-25	Heterocyclic alkylaminoheterocycles
US4374251A (en)	1983-02-15	Imidazoline containing imidazoles
Brown et al.	1980	Unfused heterobicycles as amplifiers of phleomycin. I. Some pyridinyl-and pyrazolyl-pyrimidines, bithiazoles and thiazolylpyridines
US4600720A (en)	1986-07-15	Pharmacologically active compounds
US4810800A (en)	1989-03-07	Novel imidazole dopamine beta hydroxylase inhibitors