FI52078C - Menetelmä N-alkyyli-1,4-dihydro-pyridiinien valmistamiseksi. - Google Patents

Menetelmä N-alkyyli-1,4-dihydro-pyridiinien valmistamiseksi.

Info

Publication number: FI52078C
Authority: FI; Finland
Prior art keywords: dihydropyridines; alkyl; preparation
Prior art date: 1969-05-10

Application number

FI701259A

Other languages

English (en)

Swedish (sv)

Other versions

FI52078B (fi

Inventor

Friedrich Bossert

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-05-10

Filing date

1970-05-05

Publication date

1977-06-10

1970-05-05 Application filed by Bayer Ag filed Critical Bayer Ag

1977-02-28 Application granted granted Critical

1977-02-28 Publication of FI52078B publication Critical patent/FI52078B/fi

1977-06-10 Publication of FI52078C publication Critical patent/FI52078C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI701259A 1969-05-10 1970-05-05 Menetelmä N-alkyyli-1,4-dihydro-pyridiinien valmistamiseksi. FI52078C (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE1923990A DE1923990C3 (de)	1969-05-10	1969-05-10	Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern

Publications (2)

Publication Number	Publication Date
FI52078B FI52078B (fi)	1977-02-28
FI52078C true FI52078C (fi)	1977-06-10

Family

ID=5733869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI701259A FI52078C (fi)	1969-05-10	1970-05-05	Menetelmä N-alkyyli-1,4-dihydro-pyridiinien valmistamiseksi.

Country Status (15)

Country	Link
US (1)	US3773773A (fi)
JP (1)	JPS4935277B1 (fi)
AT (1)	AT299200B (fi)
BE (1)	BE750139A (fi)
BR (1)	BR6915159D0 (fi)
DE (1)	DE1923990C3 (fi)
DK (1)	DK136246B (fi)
FI (1)	FI52078C (fi)
FR (1)	FR2051515B1 (fi)
GB (1)	GB1305793A (fi)
IL (1)	IL34304A (fi)
NL (1)	NL7006628A (fi)
NO (1)	NO133274C (fi)
SE (1)	SE376915B (fi)
YU (1)	YU33268B (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963188A1 (de) *	1969-12-17	1971-06-24	Bayer Ag	Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2117572C3 (de) *	1971-04-10	1980-03-20	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) *	1971-04-10	1979-10-11	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1430961A (en) *	1972-01-22	1976-04-07	Yamanouchi Pharma Co Ltd	1-substituted-1,4-dihyddrypyridine derivatives
US4021434A (en) *	1972-01-22	1977-05-03	Yamanouchi Pharmaceutical Co., Ltd.	Sodium β-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-1-yl]ethyl sulfate
US3988458A (en) *	1972-03-06	1976-10-26	Bayer Aktiengesellschaft	Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid esters
US3992545A (en) *	1972-03-06	1976-11-16	Bayer Aktiengesellschaft	2-Amino-4,5-dihydropyridine derivatives in pharmaceutical compositions
US3985886A (en) *	1972-03-06	1976-10-12	Bayer Aktiengesellschaft	2-Amino-4,5-dihydropyridine derivatives and process for their preparation
DE2210674C3 (de) *	1972-03-06	1981-09-24	Bayer Ag, 5090 Leverkusen	2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DD106832A5 (fi) *	1972-03-06	1974-07-05
US3917620A (en) *	1972-03-06	1975-11-04	Bayer Ag	2-Amino-4,5-dihydropyridine derivatives
US3933834A (en) *	1972-03-06	1976-01-20	Bayer Aktiengesellschaft	Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid
US3935223A (en) *	1972-03-06	1976-01-27	Bayer Aktiengesellschaft	2-Amino-1,4-dihydropyridine derivatives
US3857849A (en) *	1973-02-28	1974-12-31	Bayer Ag	2-amino-1,4-dihydropyridine derivatives
US3939171A (en) *	1972-03-06	1976-02-17	Bayer Aktiengesellschaft	2-Amino-1,4-dihydropyridine derivatives
US3887558A (en) *	1972-03-06	1975-06-03	Bayer Ag	Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof
US3957998A (en) *	1972-03-06	1976-05-18	Bayer Aktiengesellschaft	Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarboxylic acid esters for effecting coronary vessel dilation and treating hypertension
DE2218644C3 (de) *	1972-04-18	1982-08-19	Bayer Ag, 5090 Leverkusen	Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3968117A (en) *	1972-06-10	1976-07-06	Bayer Aktiengesellschaft	1,4-Dihydropyridines
DE2228363A1 (de) *	1972-06-10	1974-01-03	Bayer Ag	1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2239815C2 (de) *	1972-08-12	1983-02-10	Bayer Ag, 5090 Leverkusen	2-Alkylamino-dihydropyridine, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US4136187A (en) *	1972-08-12	1979-01-23	Bayer Aktiengesellschaft	Antihypertensive 2-amino-4,5-dihydropyridine derivatives
DE2242787C2 (de) *	1972-08-31	1982-01-21	Bayer Ag, 5090 Leverkusen	4-Phenyl-6-amino-3,4-dihydropyridon-(2)-3,5-dicarbonsäure-diäthylesterderivate, ein Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2242786A1 (de) *	1972-08-31	1974-03-14	Bayer Ag	Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
GB1409865A (en) *	1973-02-13	1975-10-15	Science Union & Cie	Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
FR2218107A1 (en) *	1973-02-20	1974-09-13	Yamanouchi Pharma Co Ltd	Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents
US4002762A (en) *	1973-03-03	1977-01-11	Bayer Aktiengesellschaft	2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension
GB1425729A (en) *	1973-06-12	1976-02-18	Smith Kline French Lab	1,4-dihydropyridine compounds
DE2335466A1 (de) *	1973-07-12	1975-01-30	Bayer Ag	Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4020178A (en) *	1973-07-12	1977-04-26	Bayer Aktiengesellschaft	1,4-Dihydropyridine esters used as coronary dilators and anti-hypertensives
FR2320750A1 (fr) *	1975-08-12	1977-03-11	Hexachimie	Dihydro-1,4 pyridines et leur application therapeutique
US4466972A (en) *	1977-06-20	1984-08-21	Sandoz Ltd.	Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
DE2738153A1 (de) *	1977-08-24	1979-03-08	Bayer Ag	2-pyridyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
FR2405937A1 (fr) *	1977-10-14	1979-05-11	Labaz	Nouveaux derives de dihydropyridine, leur procede de preparation et leur application
SU798099A1 (ru) *	1978-03-06	1981-01-23	Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp	1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь
DE3022030A1 (de) *	1980-06-12	1981-12-17	Bayer Ag, 5090 Leverkusen	4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
US4321384A (en) *	1981-02-27	1982-03-23	American Home Products Corporation	Antihypertensive agents
US4365063A (en) *	1981-08-31	1982-12-21	American Home Products Corporation	Antihypertensive agents
NZ201395A (en) *	1981-07-30	1987-02-20	Bayer Ag	Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
JPS58159490A (ja) *	1982-02-23	1983-09-21	Nikken Kagaku Kk	１，４−ジヒドロピリジン化合物
US4500532A (en) *	1983-03-03	1985-02-19	Usv Pharmaceutical Corporation	1-(Substituted aminoalkyl)-1,4-dihydropyridines
US4771057A (en) *	1986-02-03	1988-09-13	University Of Alberta	Reduced pyridyl derivatives with cardiovascular regulating properties
DE58908012D1 (de) *	1989-03-20	1994-08-11	Siemens Ag	Lichtempfindliches Gemisch.
US5258521A (en) *	1989-07-26	1993-11-02	Tosoh Corporation	Process of producing optically active propionic acid ester derivatives
DE4011695A1 (de) *	1990-04-11	1991-10-17	Bayer Ag	Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
DE4125271A1 (de) *	1991-07-31	1993-02-11	Bayer Ag	Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
DE4133257A1 (de) *	1991-10-08	1993-04-15	Bayer Ag	N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
DE4223867A1 (de) *	1992-07-20	1994-01-27	Bayer Ag	Spezieller 1,4-Dihydropyridin-3,5-dicarbonsäureester, Verfahren zu seiner Herstellung und seine pharmazeutische Verwendung
DE4430094A1 (de) *	1994-08-25	1996-02-29	Bayer Ag	Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel
JPH1039510A (ja) *	1996-07-29	1998-02-13	Nitto Denko Corp	ネガ型フォトレジスト組成物及びその利用
JP2002508324A (ja) *	1997-12-13	2002-03-19	ブリストル−マイヤーズスクイブカンパニー	サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用
US6653481B2 (en) *	2000-12-29	2003-11-25	Synthon Bv	Process for making amlodipine
CN110606822A (zh) *	2011-11-24	2019-12-24	里克特吉迪翁公司	具有hsp调节活性的1,4-二氢吡啶衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3325505A (en) *	1965-02-24	1967-06-13	Smith Kline French Lab	4-cycloalkyl(or cycloalkenyl)-dihydropyridines
US3441648A (en) *	1967-02-07	1969-04-29	Smithkline Corp	Compositions and methods for lowering blood pressure with 1,4-dihydropyridines

1969
- 1969-05-10 DE DE1923990A patent/DE1923990C3/de not_active Expired
- 1969-12-15 BR BR215159/69A patent/BR6915159D0/pt unknown
1970
- 1970-04-13 IL IL34304A patent/IL34304A/en unknown
- 1970-04-20 YU YU1026/70A patent/YU33268B/xx unknown
- 1970-04-21 GB GB1902770A patent/GB1305793A/en not_active Expired
- 1970-04-27 SE SE7005793A patent/SE376915B/xx unknown
- 1970-05-04 DK DK224370AA patent/DK136246B/da unknown
- 1970-05-04 JP JP45037598A patent/JPS4935277B1/ja active Pending
- 1970-05-04 NO NO1683/70A patent/NO133274C/no unknown
- 1970-05-05 FI FI701259A patent/FI52078C/fi active
- 1970-05-06 NL NL7006628A patent/NL7006628A/xx unknown
- 1970-05-06 AT AT409470A patent/AT299200B/de not_active IP Right Cessation
- 1970-05-08 FR FR707016863A patent/FR2051515B1/fr not_active Expired
- 1970-05-08 BE BE750139D patent/BE750139A/xx unknown
1971
- 1971-11-22 US US00201152A patent/US3773773A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB1305793A (fi)	1973-02-07
IL34304A (en)	1973-06-29
NL7006628A (fi)	1970-11-12
BR6915159D0 (pt)	1973-04-19
BE750139A (fi)	1970-11-09
NO133274B (fi)	1975-12-29
IL34304A0 (en)	1970-06-17
FR2051515B1 (fi)	1974-07-12
YU102670A (en)	1976-03-31
FR2051515A1 (fi)	1971-04-09
DK136246B (da)	1977-09-12
DE1923990B2 (de)	1978-03-30
US3773773A (en)	1973-11-20
NO133274C (fi)	1976-04-07
DK136246C (fi)	1978-02-13
AT299200B (de)	1972-06-12
DE1923990C3 (de)	1978-11-23
JPS4935277B1 (fi)	1974-09-20
YU33268B (en)	1976-08-31
SE376915B (fi)	1975-06-16
FI52078B (fi)	1977-02-28
DE1923990A1 (de)	1970-11-19

Publication	Publication Date	Title
FI52078C (fi)	1977-06-10	Menetelmä N-alkyyli-1,4-dihydro-pyridiinien valmistamiseksi.
DK125794B (da)	1973-05-07	Analogifremgangsmåde til fremstilling af 2,3-dichlorphenoxyeddikesyrederivater.
DK132174B (da)	1975-11-03	Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimider.
DK127113B (da)	1973-09-24	Analogifremgangsmåde til fremstilling af 1,4-dihydropyridiner.
FI49503C (fi)	1975-07-10	Analogiamenetelmä 1,2,3,4-tetrahydro-4-fenyyli-isokinoliinijohdannaist en valmistamiseksi.
DK140697B (da)	1979-10-29	Fremgangsmåde til fremstilling af 2-amino-4-hydroxy-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin.
BG17560A3 (bg)	1973-11-10	Метод за получаане на 4,20, 22- буфатриеноли- драмнозид- етери
DK140842B (da)	1979-11-26	Fremgangsmåde til fremstilling af 8,9-didebydro-10alfa-alkoxy-ergolener.
FI52090C (fi)	1977-06-10	Menetelmä mikrobeja tappavan 2-amino-4-hydroksi-7,7-dimetyyli-7,8-dihy dropteridiinin valmistamiseksi
FI52216C (fi)	1977-07-11	Menetelmä gamma-piperidinobutyrofenonijohdannaisten valmistamiseksi.
CH550151A (fr)	1974-06-14	Procede de preparation de nouvelles iodomethylsulfones.
DK127778B (da)	1974-01-07	Fremgangsmåde til fremstilling af 3',4'-dideoxy-kenamycin B.
DK127812B (da)	1974-01-14	Analogifremgangsmåde til fremstilling af 3,5-dibrom-zearalan.
DK126654B (da)	1973-08-06	Analogifremgangsmåde til fremstilling af 2-hydroxymethyl-3-carboxylsyreamido-quinoxalin-di-N-oxider-(1,4).
DK127421B (da)	1973-11-05	Fremgangsmåde til fremstilling af cardenolid-3[2',3'-didesoxyglycosider].
FI52862C (fi)	1977-12-12	Menetelmä uusien mikrobinvastaisten 3-(5-nitro-2-imidatsolyyli-metylee ni-amino)-2-oksatsolidinonien valmistamiseksi.
DK124331B (da)	1972-10-09	Analogifremgangsmåde til fremstilling af 14β-hydroksy-15α-acyloksy-4,20(22)-kardadienolider.
DK123818B (da)	1972-08-07	Fremgangsmåde til fremstilling af 14β-hydroxy-card-20(22)-enolider eller -bufa-20,20-dienolider.
DK122456B (da)	1972-03-06	Fremgangsmåde til fremstilling af quinoxalin-di-N-oxid-aldehyd.
FI46723C (fi)	1973-06-11	Menetelmä 1,18-dimetyyli-5alfa-H-androst-1-eenijohdannaisten valmistam iseksi.
FI47351C (fi)	1973-11-12	Menetelmä 7alfa-metyyli-1alfa,2alfa-metyleeni-androstenolonien valmist amiseksi.
DK126186B (da)	1973-06-18	Fremgangsmåde til fremstilling af 13β-alkylgona-4,9-diener.
DK125790B (da)	1973-05-07	Fremgangsmåde til fremstilling af L-β-3,4-dihydroxyphenyl-α-alanin.
FI51810C (fi)	1977-04-12	Menetelmä dimetyylisulfoksidin valmistamiseksi.
DK126190B (da)	1973-06-18	Fremgangsmåde til fremstilling af 4-chlor-14β-hydroxy-carda-4,20(22)-dienolider.