FI120252B - Menetelmä titaanista tai sen lejeeringistä valmistetun siirrännäisen käsittelemiseksi - Google Patents
Menetelmä titaanista tai sen lejeeringistä valmistetun siirrännäisen käsittelemiseksi Download PDFInfo
- Publication number
- FI120252B FI120252B FI962549A FI962549A FI120252B FI 120252 B FI120252 B FI 120252B FI 962549 A FI962549 A FI 962549A FI 962549 A FI962549 A FI 962549A FI 120252 B FI120252 B FI 120252B
- Authority
- FI
- Finland
- Prior art keywords
- graft
- titanium
- treated
- treatment
- bone
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 36
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims description 21
- 239000010936 titanium Substances 0.000 title claims description 21
- 229910052719 titanium Inorganic materials 0.000 title claims description 21
- 229910001069 Ti alloy Inorganic materials 0.000 title claims description 8
- 239000007943 implant Substances 0.000 title abstract description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000011282 treatment Methods 0.000 claims description 37
- 239000000243 solution Substances 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- -1 fluoride ions Chemical class 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 description 38
- 238000012360 testing method Methods 0.000 description 20
- 238000001556 precipitation Methods 0.000 description 12
- 229910052751 metal Inorganic materials 0.000 description 11
- 239000002184 metal Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 239000011575 calcium Substances 0.000 description 9
- 239000000956 alloy Substances 0.000 description 8
- 229910045601 alloy Inorganic materials 0.000 description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 5
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 5
- 239000007995 HEPES buffer Substances 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 229910001424 calcium ion Inorganic materials 0.000 description 5
- 239000001506 calcium phosphate Substances 0.000 description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 description 5
- 235000011010 calcium phosphates Nutrition 0.000 description 5
- 229910052731 fluorine Inorganic materials 0.000 description 5
- 239000011737 fluorine Substances 0.000 description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 230000000399 orthopedic effect Effects 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000000527 sonication Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000035876 healing Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229940091925 mediplast Drugs 0.000 description 3
- 239000012047 saturated solution Substances 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 239000007836 KH2PO4 Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000010306 acid treatment Methods 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 238000009864 tensile test Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- UGBLISDIHDMHJX-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one;hydrochloride Chemical compound [Cl-].COC1=CC=CC=C1N1CC[NH+](CCCC(=O)C=2C=CC(F)=CC=2)CC1 UGBLISDIHDMHJX-UHFFFAOYSA-N 0.000 description 1
- 241000700112 Chinchilla Species 0.000 description 1
- 208000002354 Edentulous Jaw Diseases 0.000 description 1
- 229910000997 High-speed steel Inorganic materials 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005524 ceramic coating Methods 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000007586 pull-out test Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F1/00—Etching metallic material by chemical means
- C23F1/10—Etching compositions
- C23F1/14—Aqueous compositions
- C23F1/16—Acidic compositions
- C23F1/26—Acidic compositions for etching refractory metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Metallurgy (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
- ing And Chemical Polishing (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9304209 | 1993-12-20 | ||
| SE9304209A SE9304209D0 (sv) | 1993-12-20 | 1993-12-20 | New process for treating a metallic surgical implant |
| SE9401928A SE503638C2 (sv) | 1994-06-03 | 1994-06-03 | Metallimplantat vars yta innehåller fluor och/eller fluorjoner |
| SE9401928 | 1994-06-03 | ||
| PCT/SE1994/001225 WO1995017217A1 (en) | 1993-12-20 | 1994-12-19 | Metallic implant and process for treating a metallic implant |
| SE9401225 | 1994-12-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962549A0 FI962549A0 (fi) | 1996-06-19 |
| FI962549L FI962549L (fi) | 1996-06-19 |
| FI120252B true FI120252B (fi) | 2009-08-31 |
Family
ID=26661906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962549A FI120252B (fi) | 1993-12-20 | 1996-06-19 | Menetelmä titaanista tai sen lejeeringistä valmistetun siirrännäisen käsittelemiseksi |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0738160B1 (no) |
| JP (1) | JP3683910B2 (no) |
| AT (1) | ATE337032T1 (no) |
| AU (1) | AU700523B2 (no) |
| DE (1) | DE69434831T2 (no) |
| ES (1) | ES2270422T3 (no) |
| FI (1) | FI120252B (no) |
| NO (1) | NO311072B1 (no) |
| NZ (1) | NZ277905A (no) |
| WO (1) | WO1995017217A1 (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048870B1 (en) | 1993-12-20 | 2006-05-23 | Astrazeneca Ab | Metallic implant and process for treating a metallic implant |
| SE523236C2 (sv) | 2002-07-19 | 2004-04-06 | Astra Tech Ab | Ett implantat och ett förfarande för behandling av en implantatyta |
| SE523288C2 (sv) * | 2002-07-19 | 2004-04-06 | Astra Tech Ab | Ett implantat och ett förfarande för behandling av en implantatyta |
| WO2006091582A2 (en) | 2005-02-24 | 2006-08-31 | Implant Innovations, Inc. | Surface treatment methods for implants made of titanium or titanium alloy |
| NO325290B1 (no) * | 2006-10-10 | 2008-03-17 | Gunnar Rolla | Titanimplantat og fremgangsmate for fremstilling derav |
| EP2121053B1 (en) * | 2006-12-21 | 2013-07-24 | Corticalis AS | Metal oxide scaffolds |
| EP2014259A1 (en) | 2007-07-09 | 2009-01-14 | Astra Tech AB | A bone tissue implant comprising lithium ions |
| EP2014319A1 (en) | 2007-07-09 | 2009-01-14 | Astra Tech AB | A bone tissue implant comprising strontium ions |
| ES2352635B1 (es) * | 2010-09-16 | 2011-12-29 | Biotechnology Institute, I Mas D, S.L. | Implante con calcio en su superficie, y método de modificación de la superficie de un implante para dotar a dicha superficie de calcio. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE58905636D1 (de) * | 1989-03-23 | 1993-10-21 | Straumann Inst Ag | Metallisches Implantat. |
| JP2930619B2 (ja) * | 1989-10-30 | 1999-08-03 | 春幸 川原 | チタンもしくはチタン基合金製生体修復部材及びその表面処理法 |
| NO924697D0 (no) * | 1992-12-04 | 1992-12-04 | Jan Erik Ellingsen | Kirurgisk implantat og en fremgangsmaate for behandling avkirurgisk implantat |
-
1994
- 1994-12-19 NZ NZ277905A patent/NZ277905A/en not_active IP Right Cessation
- 1994-12-19 AT AT95904729T patent/ATE337032T1/de active
- 1994-12-19 WO PCT/SE1994/001225 patent/WO1995017217A1/en active IP Right Grant
- 1994-12-19 ES ES95904729T patent/ES2270422T3/es not_active Expired - Lifetime
- 1994-12-19 EP EP95904729A patent/EP0738160B1/en not_active Expired - Lifetime
- 1994-12-19 AU AU13298/95A patent/AU700523B2/en not_active Ceased
- 1994-12-19 JP JP51735895A patent/JP3683910B2/ja not_active Expired - Lifetime
- 1994-12-19 DE DE69434831T patent/DE69434831T2/de not_active Expired - Lifetime
-
1996
- 1996-06-18 NO NO19962580A patent/NO311072B1/no not_active IP Right Cessation
- 1996-06-19 FI FI962549A patent/FI120252B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69434831D1 (de) | 2006-10-05 |
| NO311072B1 (no) | 2001-10-08 |
| AU1329895A (en) | 1995-07-10 |
| ES2270422T3 (es) | 2007-04-01 |
| JP3683910B2 (ja) | 2005-08-17 |
| JPH09506800A (ja) | 1997-07-08 |
| FI962549A0 (fi) | 1996-06-19 |
| NZ277905A (en) | 1997-04-24 |
| NO962580L (no) | 1996-06-18 |
| WO1995017217A1 (en) | 1995-06-29 |
| NO962580D0 (no) | 1996-06-18 |
| ATE337032T1 (de) | 2006-09-15 |
| FI962549L (fi) | 1996-06-19 |
| EP0738160B1 (en) | 2006-08-23 |
| DE69434831T2 (de) | 2007-03-15 |
| AU700523B2 (en) | 1999-01-07 |
| EP0738160A1 (en) | 1996-10-23 |
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Legal Events
| Date | Code | Title | Description |
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