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FI108862B - N-p-halobensoylmetylderivat av 4-(p-fluorofenyl)-3-[[3,4-(metylenidioxi]-fenoxi]metylpiperidin - Google Patents

N-p-halobensoylmetylderivat av 4-(p-fluorofenyl)-3-[[3,4-(metylenidioxi]-fenoxi]metylpiperidin Download PDF

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Publication number
FI108862B
FI108862B FI955387A FI955387A FI108862B FI 108862 B FI108862 B FI 108862B FI 955387 A FI955387 A FI 955387A FI 955387 A FI955387 A FI 955387A FI 108862 B FI108862 B FI 108862B
Authority
FI
Finland
Prior art keywords
fluorophenyl
phenoxy
piperidines
compound
benzoylmethyl
Prior art date
Application number
FI955387A
Other languages
English (en)
Finnish (fi)
Other versions
FI955387A0 (sv
FI955387A (sv
Inventor
Rafael Foguet
Santiago Gubert
Aurelio Sacristan
Jose A Ortiz
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of FI955387A0 publication Critical patent/FI955387A0/sv
Publication of FI955387A publication Critical patent/FI955387A/sv
Application granted granted Critical
Publication of FI108862B publication Critical patent/FI108862B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (6)

1. N-Bensoylmetyl-piperidiner, kännetecknade av att de är N-p-halogenbensoylderivater av 4-(p-fluorofenyl)-3-[[3,4-metylendioxi)fenoxi)metyl)piperidiner enligt den allmänna formeln (I) p C·^2 °Λ /Γ\ (I) väri x är en halogenatom, samt deras farmaceutiska acceptabla syraadditionssalter.
2. N-Bensoylmetyl-piperidiner enligt patentkravet 1, kännetecknade av att Xär fluor eller klor.
. 3. N-Bensoylmetyl-piperidiner enligt patentkravet 1 eller 2, kännetecknade av att ,·. de farmaceutiskt acceptabla syraadditionssalterna är hydroklorider. » *
4. Användning av N-bensoylmetyl-piperidiner enligt patentkravet 1 eller 2 i ; ’',: antidepressiva läkemedel.
'. ‘ ‘ 5. Farmaceutisk komposition kännetecknadavatt den innefattar minst en förening enligt patentkravet 1 eller 2, eventuellt tillsammans med farmaceutiskt acceptabla bärare ’ ·’ ’: och/eller adjuvantia. j . ’. : i '· '* 108862
6. Ett förfarande för tillverkning av föreningarna enligt patentkravet 1 eller 2, k ä n n e t e c k n a t av att det innefattar alkylering av föreningen enligt formel II > 111» CH2 fhOOh med en p-halogenfenacylförening enligt formel III VO* YCH2 (III) väri Y är klor eller brom, och X är som definierats i patentkravet 1, ooh om sä önskas, omvandling av en förening enligt formel I i form av en fri bas tili ett syraadditionssalt v. därav. < * · ' » » * · » >
FI955387A 1994-03-18 1995-11-08 N-p-halobensoylmetylderivat av 4-(p-fluorofenyl)-3-[[3,4-(metylenidioxi]-fenoxi]metylpiperidin FI108862B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES9400582 1994-03-18
ES09400582A ES2102295B1 (es) 1994-03-18 1994-03-18 Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
PCT/EP1995/001007 WO1995025732A1 (en) 1994-03-18 1995-03-17 N-p-HALOBENZOYLMETHYL DERIVATIVES OF 4-(p-FLUOROPHENYL)-3-((3,4-METHYLENE-DIOXY)PHENOXY)METHYL)PIPERIDINE
EP9501007 1995-03-17

Publications (3)

Publication Number Publication Date
FI955387A0 FI955387A0 (sv) 1995-11-08
FI955387A FI955387A (sv) 1995-11-08
FI108862B true FI108862B (sv) 2002-04-15

Family

ID=8285616

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955387A FI108862B (sv) 1994-03-18 1995-11-08 N-p-halobensoylmetylderivat av 4-(p-fluorofenyl)-3-[[3,4-(metylenidioxi]-fenoxi]metylpiperidin

Country Status (19)

Country Link
US (1) US5665736A (sv)
EP (1) EP0699198B1 (sv)
JP (1) JP3213324B2 (sv)
KR (1) KR0182093B1 (sv)
AT (1) ATE181734T1 (sv)
AU (1) AU678320B2 (sv)
CA (1) CA2163253C (sv)
DE (1) DE69510510T2 (sv)
DK (1) DK0699198T3 (sv)
ES (1) ES2102295B1 (sv)
FI (1) FI108862B (sv)
GR (1) GR3031282T3 (sv)
IL (1) IL112763A (sv)
NO (1) NO308002B1 (sv)
NZ (1) NZ283130A (sv)
PH (1) PH31388A (sv)
TW (1) TW416956B (sv)
WO (1) WO1995025732A1 (sv)
ZA (1) ZA951963B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117557B1 (es) * 1996-02-29 1999-07-01 Ferrer Int Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
EP1384720A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9700690D0 (en) 1997-01-15 1997-03-05 Smithkline Beecham Plc Novel process
JP2002514222A (ja) 1997-05-29 2002-05-14 スミスクライン・ビーチャム・コーポレイション 新規方法
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
US7517892B2 (en) 2000-09-11 2009-04-14 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
DE3688827T2 (de) * 1985-10-25 1994-03-31 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel.
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
DE69510510T2 (de) 1999-11-18
FI955387A0 (sv) 1995-11-08
CA2163253C (en) 2004-08-10
JPH08510477A (ja) 1996-11-05
GR3031282T3 (en) 1999-12-31
AU2109495A (en) 1995-10-09
CA2163253A1 (en) 1995-09-28
ES2102295B1 (es) 1998-04-01
EP0699198A1 (en) 1996-03-06
EP0699198B1 (en) 1999-06-30
ZA951963B (en) 1996-03-11
TW416956B (en) 2001-01-01
PH31388A (en) 1998-10-29
FI955387A (sv) 1995-11-08
AU678320B2 (en) 1997-05-22
NZ283130A (en) 1996-11-26
JP3213324B2 (ja) 2001-10-02
NO308002B1 (no) 2000-07-03
ATE181734T1 (de) 1999-07-15
ES2102295A1 (es) 1997-07-16
IL112763A0 (en) 1995-05-26
DK0699198T3 (da) 1999-11-22
KR960702456A (ko) 1996-04-27
DE69510510D1 (de) 1999-08-05
NO954538D0 (no) 1995-11-10
NO954538L (no) 1995-11-10
IL112763A (en) 1998-03-10
US5665736A (en) 1997-09-09
WO1995025732A1 (en) 1995-09-28
KR0182093B1 (ko) 1999-05-01

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