FI104175B1 - Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten - Google Patents

Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten

Info

Publication number: FI104175B1
Authority: FI; Finland
Prior art keywords: 4alkyl; represents hydrogen; 4alkyloxy; halo; substituted
Prior art date: 1991-06-13

Application number

FI935556A

Other languages

English (en)

Finnish (fi)

Other versions

FI935556A0 (fi

FI104175B (sv

FI935556A (fi

Inventor

Frans Eduard Janssens

Gaston Stanislas Marcell Diels

Joseph Elisabeth Leenaerts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-13

Filing date

1993-12-10

Publication date

1999-11-30

1993-12-10 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1993-12-10 Publication of FI935556A0 publication Critical patent/FI935556A0/fi

1993-12-10 Publication of FI935556A publication Critical patent/FI935556A/fi

1999-11-30 Application granted granted Critical

1999-11-30 Publication of FI104175B publication Critical patent/FI104175B/sv

1999-11-30 Publication of FI104175B1 publication Critical patent/FI104175B1/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Paper (AREA)
Detergent Compositions (AREA)

FI935556A 1991-06-13 1993-12-10 Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten FI104175B1 (sv)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US71448691A	1991-06-13	1991-06-13
US71448691		1991-06-13
US85363192A	1992-03-18	1992-03-18
US85363192		1992-03-18
EP9201330		1992-06-09
PCT/EP1992/001330 WO1992022551A1 (en)	1991-06-13	1992-06-09	IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE

Publications (4)

Publication Number	Publication Date
FI935556A0 FI935556A0 (fi)	1993-12-10
FI935556A FI935556A (fi)	1993-12-10
FI104175B FI104175B (sv)	1999-11-30
FI104175B1 true FI104175B1 (sv)	1999-11-30

Family

ID=27109168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI935556A FI104175B1 (sv)	1991-06-13	1993-12-10	Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten

Country Status (28)

Country	Link
US (1)	US5468743A (sv)
EP (2)	EP0518435A1 (sv)
JP (1)	JP2845407B2 (sv)
KR (1)	KR0184017B1 (sv)
CN (2)	CN1033586C (sv)
AT (1)	ATE250061T1 (sv)
AU (1)	AU652840B2 (sv)
CA (1)	CA2103242C (sv)
DE (1)	DE69233205T2 (sv)
DK (1)	DK0588858T3 (sv)
DZ (1)	DZ1582A1 (sv)
ES (1)	ES2207632T3 (sv)
FI (1)	FI104175B1 (sv)
HR (1)	HRP920155A2 (sv)
HU (2)	HU221016B1 (sv)
IE (1)	IE921918A1 (sv)
IL (1)	IL101850A (sv)
MA (1)	MA22553A1 (sv)
MX (1)	MX9202856A (sv)
NO (2)	NO934492D0 (sv)
NZ (1)	NZ242774A (sv)
PT (1)	PT588858E (sv)
SG (1)	SG47823A1 (sv)
SI (1)	SI9200105B (sv)
TN (1)	TNSN92048A1 (sv)
TW (1)	TW218381B (sv)
WO (1)	WO1992022551A1 (sv)
YU (1)	YU61192A (sv)

Families Citing this family (34)

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IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
GR1001393B (el) *	1992-10-12	1993-10-29	Janssen Pharmaceutica Nv	Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
PL176593B1 (pl) *	1992-12-04	1999-06-30	Janssen Pharmaceutica Nv	Nowe związki, pochodne triazolobenzoazepiny o działaniu przeciwalergicznym, kompozycja farmaceutyczna i sposób wytwarzania pochodnych triazolobenzoazepiny
KR100346802B1 (ko) *	1993-07-13	2002-11-29	얀센 파마슈티카 엔.브이.	항앨러지성이미다조아제핀
TW382017B (en)	1995-12-27	2000-02-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en)	1996-03-19	2003-04-11	Janssen Pharmaceutica Nv	Fused imidazole derivatives as multidrug resistance modulators
US6544979B1 (en)	1997-09-18	2003-04-08	Janssen Pharmaceuticals, N.V.	Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
NZ512870A (en) *	1998-12-19	2003-11-28	Janssen Pharmaceutica Nv	Antihistaminic spiro compounds
WO2002100862A2 (en)	2001-06-12	2002-12-19	Janssen Pharmaceutica N.V.	Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
CN1160557C (zh)	2001-09-03	2004-08-04	北京埃索特核电子机械有限公司	钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备
AU2006221984C1 (en)	2005-03-08	2012-02-09	Janssen Pharmaceutica N.V.	Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
US20070077303A1 (en) *	2005-09-30	2007-04-05	Azaam Alli	Methods for providing oxidatively stable ophthalmic compositions
US20070077302A1 (en) *	2005-09-30	2007-04-05	Azaam Alli	Methods for stabilizing ophthalmic compositions
MX2008012657A (es) *	2006-03-31	2009-02-19	Vistakon Pharmaceuticals Llc	Tratamientos de las alergias oculares.
US20080139531A1 (en) *	2006-12-04	2008-06-12	Alcon Manufacturing Ltd.	Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
TW200902025A (en) *	2007-04-11	2009-01-16	Alcon Res Ltd	Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20090182035A1 (en) *	2007-04-11	2009-07-16	Alcon Research, Ltd.	Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
AU2010300421B2 (en) *	2009-10-01	2014-01-23	Alcon Research, Ltd.	Olopatadine compositions and uses thereof
AR079170A1 (es) *	2009-12-10	2011-12-28	Lilly Co Eli	Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
AU2012275113A1 (en) *	2011-06-29	2014-01-30	Allergan, Inc.	Alcaftadine for use in the treatment of urticaria
US9409913B2 (en) *	2012-11-21	2016-08-09	Enaltec Labs Private Limited	Polymorphic forms of alcaftadine
WO2014083571A1 (en) *	2012-11-29	2014-06-05	Neuland Laboratories Limited	A process for the preparation of alcaftadine
WO2014087208A2 (en) *	2012-12-06	2014-06-12	Enaltec Labs Pvt. Ltd.	A process of preparing alcaftadine
CA2907396C (en)	2013-03-25	2021-11-02	Crystal Pharma S.A.U.	Methods for the preparation of alcaftadine
CN103408549B (zh) *	2013-06-14	2016-01-20	苏州汇和药业有限公司	一种阿卡他定中间体的制备方法
AU2015308350B2 (en)	2014-08-29	2020-03-05	Tes Pharma S.R.L.	Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
CN104710427A (zh) *	2014-12-20	2015-06-17	威海法莫斯特医药技术开发有限公司	一种阿卡他定新晶型
CN104860920B (zh) *	2015-04-15	2017-08-25	武汉武药科技有限公司	一种阿卡他定中间体的制备方法
CN105130993B (zh) *	2015-07-28	2018-01-12	武汉武药科技有限公司	一种合成阿卡他定的新氧化方法
CN104987337B (zh) *	2015-07-28	2018-01-12	武汉武药科技有限公司	一种制备阿卡他定的氧化方法
AU2017310520A1 (en)	2016-08-12	2019-03-21	Silk Technologies, Ltd.	Silk-derived protein for treating inflammation
CN108727384A (zh) *	2018-07-07	2018-11-02	张正光	一种阿卡他定中间体的制备方法
JP2023530166A (ja) *	2020-06-15	2023-07-13	アルケム・ラボラトリーズ・リミテッド	アルカフタジンとコルチコステロイドの組み合わせ
MX2023011546A (es)	2021-04-01	2023-10-06	Alkem Laboratories Ltd	Composiciones nasales que comprenden alcaftadina.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4148903A (en) *	1977-07-28	1979-04-10	Merck & Co., Inc.	Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives
WO1992006981A1 (en) *	1990-10-10	1992-04-30	Schering Corporation	Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition

1992
- 1992-05-13 IL IL10185092A patent/IL101850A/en not_active IP Right Cessation
- 1992-05-15 NZ NZ242774A patent/NZ242774A/en not_active IP Right Cessation
- 1992-05-16 CN CN92105040A patent/CN1033586C/zh not_active Expired - Lifetime
- 1992-05-18 DZ DZ920051A patent/DZ1582A1/fr active
- 1992-05-21 TW TW081103954A patent/TW218381B/zh not_active IP Right Cessation
- 1992-06-09 JP JP4510733A patent/JP2845407B2/ja not_active Expired - Lifetime
- 1992-06-09 AT AT92911635T patent/ATE250061T1/de active
- 1992-06-09 EP EP92201666A patent/EP0518435A1/en active Pending
- 1992-06-09 US US08/142,474 patent/US5468743A/en not_active Expired - Lifetime
- 1992-06-09 PT PT92911635T patent/PT588858E/pt unknown
- 1992-06-09 DE DE69233205T patent/DE69233205T2/de not_active Expired - Lifetime
- 1992-06-09 EP EP92911635A patent/EP0588858B1/en not_active Expired - Lifetime
- 1992-06-09 WO PCT/EP1992/001330 patent/WO1992022551A1/en active IP Right Grant
- 1992-06-09 ES ES92911635T patent/ES2207632T3/es not_active Expired - Lifetime
- 1992-06-09 KR KR1019930703788A patent/KR0184017B1/ko not_active IP Right Cessation
- 1992-06-09 CA CA002103242A patent/CA2103242C/en not_active Expired - Lifetime
- 1992-06-09 HU HU9303553A patent/HU221016B1/hu unknown
- 1992-06-09 DK DK92911635T patent/DK0588858T3/da active
- 1992-06-09 AU AU19001/92A patent/AU652840B2/en not_active Expired
- 1992-06-09 SG SG1996004579A patent/SG47823A1/en unknown
- 1992-06-10 HR HR920155A patent/HRP920155A2/hr not_active Application Discontinuation
- 1992-06-11 MA MA22843A patent/MA22553A1/fr unknown
- 1992-06-12 SI SI9200105A patent/SI9200105B/sl unknown
- 1992-06-12 MX MX9202856A patent/MX9202856A/es unknown
- 1992-06-12 YU YU61192A patent/YU61192A/sh unknown
- 1992-06-15 TN TNTNSN92048A patent/TNSN92048A1/fr unknown
- 1992-07-01 IE IE191892A patent/IE921918A1/en not_active Application Discontinuation
1993
- 1993-12-09 NO NO934492D patent/NO934492D0/no unknown
- 1993-12-09 NO NO934492A patent/NO300636B1/no not_active IP Right Cessation
- 1993-12-10 FI FI935556A patent/FI104175B1/sv not_active IP Right Cessation
1995
- 1995-06-06 HU HU95P/P00164P patent/HU211289A9/hu unknown
1996
- 1996-04-24 CN CN96106116A patent/CN1070368C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU652840B2 (en)	1994-09-08
HRP920155A2 (en)	1994-08-31
MA22553A1 (fr)	1992-12-31
CN1033586C (zh)	1996-12-18
SI9200105B (en)	2001-10-31
CN1142360A (zh)	1997-02-12
NZ242774A (en)	1995-02-24
IL101850A (en)	1996-01-31
IL101850A0 (en)	1992-12-30
DK0588858T3 (da)	2004-01-26
IE921918A1 (en)	1992-12-16
EP0588858B1 (en)	2003-09-17
DE69233205T2 (de)	2004-06-24
FI935556A0 (fi)	1993-12-10
ES2207632T3 (es)	2004-06-01
HU211289A9 (en)	1995-11-28
FI104175B (sv)	1999-11-30
FI935556A (fi)	1993-12-10
TNSN92048A1 (fr)	1993-06-08
DE69233205D1 (de)	2003-10-23
MX9202856A (es)	1992-12-01
NO934492D0 (no)	1993-12-09
US5468743A (en)	1995-11-21
JP2845407B2 (ja)	1999-01-13
SI9200105A (en)	1992-12-31
PT588858E (pt)	2004-02-27
NO934492L (no)	1994-01-04
SG47823A1 (en)	1998-04-17
CA2103242C (en)	2002-11-12
HU9303553D0 (en)	1994-04-28
YU61192A (sh)	1994-09-09
KR0184017B1 (ko)	1999-05-01
EP0588858A1 (en)	1994-03-30
JPH06507889A (ja)	1994-09-08
AU1900192A (en)	1993-01-12
HU221016B1 (hu)	2002-07-29
EP0518435A1 (en)	1992-12-16
NO300636B1 (no)	1997-06-30
WO1992022551A1 (en)	1992-12-23
CA2103242A1 (en)	1992-12-14
TW218381B (sv)	1994-01-01
DZ1582A1 (fr)	2002-02-17
ATE250061T1 (de)	2003-10-15
CN1068118A (zh)	1993-01-20
HUT70529A (en)	1995-10-30
CN1070368C (zh)	2001-09-05

Publication	Publication Date	Title
FI104175B1 (sv)	1999-11-30	Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten
FI104077B1 (sv)	1999-11-15	Förfarande för framställning av terapeutiskt användbara imidazo[1,2-a](pyrrolo-, tieno- eller furano)[3,2-d]azepinderivat och mellanprodukt
HK1052687A1 (en)	2003-09-26	Preparation of a camptothecin derivative by intramolecular cyclisation.
NO950202L (no)	1995-01-19	Tetracykliske forbindelser, fremgangsmåter og intermediater for fremstilling og anvendelse derav
ATE239023T1 (de)	2003-05-15	Antiallergische imidazo(1,2-a)thieno(2,3- d)azepinderivate

Legal Events

Date	Code	Title	Description
2012-08-10	MA	Patent expired