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ES8800679A1 - Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza - Google Patents

Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza

Info

Publication number
ES8800679A1
ES8800679A1 ES554898A ES554898A ES8800679A1 ES 8800679 A1 ES8800679 A1 ES 8800679A1 ES 554898 A ES554898 A ES 554898A ES 554898 A ES554898 A ES 554898A ES 8800679 A1 ES8800679 A1 ES 8800679A1
Authority
ES
Spain
Prior art keywords
derivatives
procedure
aza
piperiliden
dihidrodibenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554898A
Other languages
English (en)
Other versions
ES554898A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8800679(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/839,016 external-priority patent/US4731447A/en
Priority claimed from US06/838,974 external-priority patent/US4659716A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES554898A0 publication Critical patent/ES554898A0/es
Publication of ES8800679A1 publication Critical patent/ES8800679A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PIRERILIDEN-DIHIDRODIBENZO (A,D) CICLOHEPTENOS Y SUS DERIVADOS AZA. CONSISTE EN SOMMETER A CONDENSACION INTRAMOLECUALR EL COMPUESTO DE FORMULA (II), POR TRATAMIENTO CONUN EXCESO DE ACIDO, CON UNA FUNCION DE ACIDEZ DE HAMETT DE MENOS 12 O INFERIOR, A UNA TEMPERATURA DE C50 A 150JC Y EN PRESENCIA DE UN DISOLVENTE INERTE, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: A, B, C Y D, CH, SI BIEN UNO DE ELLOS PUEDE SER; N; R1, R2, R3 Y R4, H, ALQUILO DE C 1 A 6 Y OTROS; R5, H, ALQUILO Y OTROS; R5K, COMO R5, O GRUPO N-PROTECTOR. SE UTILIZANN COMO ANTIHISTAMINICOS.
ES554898A 1985-05-13 1986-05-13 Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza Expired ES8800679A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73342885A 1985-05-13 1985-05-13
US06/839,016 US4731447A (en) 1985-05-13 1986-03-12 Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US06/838,974 US4659716A (en) 1984-02-15 1986-03-12 Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines

Publications (2)

Publication Number Publication Date
ES554898A0 ES554898A0 (es) 1987-11-16
ES8800679A1 true ES8800679A1 (es) 1987-11-16

Family

ID=27419175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554898A Expired ES8800679A1 (es) 1985-05-13 1986-05-13 Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza

Country Status (15)

Country Link
EP (1) EP0208855B1 (es)
JP (2) JP2511412B2 (es)
AR (1) AR241463A1 (es)
AU (2) AU600665B2 (es)
CA (1) CA1272480A (es)
DE (1) DE3677842D1 (es)
DK (1) DK173765B1 (es)
ES (1) ES8800679A1 (es)
FI (2) FI90977C (es)
HK (1) HK75993A (es)
HU (1) HU199138B (es)
IE (1) IE59110B1 (es)
IL (1) IL78771A (es)
PT (1) PT82570B (es)
SG (1) SG69193G (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
ES2056214T3 (es) * 1988-04-28 1994-10-01 Schering Corp Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
AU620996B2 (en) * 1989-07-04 1992-02-27 Hokuriku Pharmaceutical Co. Ltd. 4-{(dibenzocycloheptene) or (dibenzoxepin)}-1-substituted piperidines
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
CN1047774C (zh) * 1996-09-10 1999-12-29 上海华联制药有限公司 氮杂二苯并环庚烯酮类化合物的制备方法
EP0978281B1 (en) * 1997-04-25 2002-07-17 Schering-Plough Kabushiki Kaisha Eyedrops containing a loratidine metabolite
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
DE69919720D1 (de) * 1998-07-24 2004-09-30 Russinsky Ltd Verfahren zur herstellung von benzocycloheptapyridin-11-one
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
EP1131296A2 (en) * 1998-11-20 2001-09-12 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
PE20001334A1 (es) * 1998-12-18 2000-12-01 Schering Corp Procesos para preparar compuestos triciclicos que tienen actividad antihistaminica
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
PE20080151A1 (es) 2006-06-01 2008-02-25 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para su absorcion en el colon
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (es) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) * 1973-10-11 1977-10-19 Beecham Group Ltd Reduced bicyclic pyridone derivatives
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
AU570306B2 (en) * 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.

Also Published As

Publication number Publication date
ES554898A0 (es) 1987-11-16
IE861259L (en) 1986-11-13
EP0208855A1 (en) 1987-01-21
FI861987L (fi) 1986-11-14
JP2519880B2 (ja) 1996-07-31
HU199138B (en) 1990-01-29
SG69193G (en) 1993-08-06
FI87648B (fi) 1992-10-30
PT82570B (pt) 1988-11-30
FI87648C (fi) 1993-02-10
AU600665B2 (en) 1990-08-23
EP0208855B1 (en) 1991-03-06
IL78771A (en) 1990-11-29
DK220986D0 (da) 1986-05-13
CA1272480A (en) 1990-08-07
AU638019B2 (en) 1993-06-17
JP2511412B2 (ja) 1996-06-26
FI861987A0 (fi) 1986-05-13
IL78771A0 (en) 1986-08-31
DK220986A (da) 1986-11-14
FI90977C (fi) 1994-04-25
HK75993A (en) 1993-08-06
AU5737486A (en) 1986-12-18
FI902315A0 (fi) 1990-05-09
DK173765B1 (da) 2001-09-17
HUT41731A (en) 1987-05-28
PT82570A (en) 1986-06-01
AU5702690A (en) 1990-10-04
IE59110B1 (en) 1994-01-12
DE3677842D1 (de) 1991-04-11
FI90977B (fi) 1994-01-14
AR241463A1 (es) 1992-07-31
JPS61289087A (ja) 1986-12-19
JPH0859657A (ja) 1996-03-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070807