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ES8708182A1 - Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties. - Google Patents

Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties.

Info

Publication number
ES8708182A1
ES8708182A1 ES551701A ES551701A ES8708182A1 ES 8708182 A1 ES8708182 A1 ES 8708182A1 ES 551701 A ES551701 A ES 551701A ES 551701 A ES551701 A ES 551701A ES 8708182 A1 ES8708182 A1 ES 8708182A1
Authority
ES
Spain
Prior art keywords
tetracycline
possessing anti
effective
compositions possessing
antibacterial tetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551701A
Other languages
Spanish (es)
Other versions
ES551701A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of ES8708182A1 publication Critical patent/ES8708182A1/en
Publication of ES551701A0 publication Critical patent/ES551701A0/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)

Abstract

METODO PARA PREPARAR UNA COMPOSICION QUE CONTIENE TETRACICLINA. COMPRENDE: A) FORMAR UNA MEZCLA DE DESDIMETILAMINO-TETRACICLINA EFICAZ COMO ANTI-COLAGENSA, CON UN VOLUMEN POLIMERO ADECUADO, NO TENIENDO LA TETRACICLINA ACTIVIDAD ANTIMICROBIANA EFICAZ Y ENCONTRANDOSE EN UNA CANTIDAD DE 5-50 POR CIENTO DE SU DOSIFICACION ESTANDAR COMO AGENTE ANTIMICROBIANO, SIENDO EL VEHICULO POLIMERO UN MATERIAL POLIMERO SINTETICO COMO COPOLIMERO DE ETILENO Y ACETATO DE VINILO, SIENDO CAPAZ DE LIBERAR CONTROLABLEMENTE LA TETRACICLINA INCORPORADA EN EL DURANTE CIERTO PERIODO DE TIEMPO; B) CONFORMAR LA MEZCLA RESULTANTE PARA CONVERTIRLA EN FIBRAS, PELICULAS O PARTICULAS, SIENDO CAPACES DE SER CONFIGURADAS A TEMPERATURA AMBIENTE ADOPTANDO UNA FORMA ADECUADA PARA SU APLICACION DIRECTA A UNA SUPERFICIE O LUGAR. SE UTILIZA PARA PROTEGER LESIONES DE LA PIEL QUE MUESTRAN DESTRUCCION PATOLOGICA DEL COLAGENO.METHOD FOR PREPARING A COMPOSITION CONTAINING TETRACYCLINE. IT COMPRISES: A) FORMING A DEDIMETHYLAMINO-TETRACYCLINE MIXTURE EFFECTIVE AS ANTI-COLLAGE, WITH AN ADEQUATE POLYMER VOLUME, THE TETRACYCLINE NOT HAVING EFFECTIVE ANTIMICROBIAL ACTIVITY AND BEING IN AN AMOUNT OF 5-50 PERCENT OF ITS STANDARD DOSAGE AS AN ANTIMICROBIAL AGENT, BEING THE POLYMER VEHICLE A SYNTHETIC POLYMER MATERIAL SUCH AS A COPOLYMER OF ETHYLENE AND VINYL ACETATE, BEING CAPABLE OF CONTROLLABLE RELEASE OF THE TETRACYCLINE INCORPORATED IN IT DURING A CERTAIN PERIOD OF TIME; B) SHAPING THE RESULTING MIXTURE TO CONVERT IT INTO FIBERS, FILMS OR PARTICLES, BEING CAPABLE OF BEING SHAPED AT ROOM TEMPERATURE ADOPTING A SUITABLE FORM FOR ITS DIRECT APPLICATION TO A SURFACE OR PLACE. IT IS USED TO PROTECT SKIN LESIONS THAT SHOW PATHOLOGICAL DESTRUCTION OF COLLAGEN.

ES551701A 1985-02-07 1986-02-06 Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties. Expired ES8708182A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/699,048 US4704383A (en) 1983-12-29 1985-02-07 Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same

Publications (2)

Publication Number Publication Date
ES8708182A1 true ES8708182A1 (en) 1987-10-01
ES551701A0 ES551701A0 (en) 1987-10-01

Family

ID=24807719

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551701A Expired ES8708182A1 (en) 1985-02-07 1986-02-06 Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties.

Country Status (12)

Country Link
US (1) US4704383A (en)
EP (1) EP0195906B1 (en)
JP (1) JP2676080B2 (en)
AT (1) ATE81460T1 (en)
AU (1) AU583884B2 (en)
CA (1) CA1297410C (en)
DE (1) DE3686956T2 (en)
DK (1) DK174997B1 (en)
ES (1) ES8708182A1 (en)
GR (1) GR860333B (en)
IE (1) IE58813B1 (en)
ZA (1) ZA86838B (en)

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GR861167B (en) * 1985-05-02 1986-09-30 Research Corp Bone targeted inhibitors of carbonic anhydrase
JP3016587B2 (en) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク Combination of non-steroidal anti-inflammatory drug and tetracycline
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5045538A (en) * 1990-06-28 1991-09-03 The Research Foundation Of State University Of New York Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
WO1992012717A2 (en) * 1991-01-15 1992-08-06 A composition containing a tetracycline and use for inhibiting angiogenesis
US5223248A (en) * 1991-02-11 1993-06-29 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing antiplaque properties
US5770588A (en) * 1991-02-11 1998-06-23 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
CA2094874C (en) * 1992-04-27 2003-02-11 Thomas F. Mcnamara Non-antibacterial tetracycline compositons possessing antiplaque properties
US5258371A (en) * 1992-05-29 1993-11-02 Kuraray Co., Ltd. Method to reduce connective tissue destruction
DE69331387T2 (en) * 1992-09-10 2002-08-22 Childrens Medical Center BIODEGRADABLE POLYMER MATRICATES WITH DELAYED RELEASE OF LOCALANE AESTHETICS
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6043231A (en) * 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5641636A (en) * 1994-05-20 1997-06-24 University Of Pennsylvania Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity
US6140099A (en) * 1994-05-20 2000-10-31 The Trustees Of The University Of Pennsylvania Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity
ATE267587T1 (en) 1995-06-09 2004-06-15 Euro Celtique Sa FORMULATIONS AND METHODS FOR PROLONGED LOCAL ANESTHESIA
AU733867B2 (en) 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
US5827840A (en) * 1996-08-01 1998-10-27 The Research Foundation Of State University Of New York Promotion of wound healing by chemically-modified tetracyclines
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
JP2908375B2 (en) 1997-04-01 1999-06-21 ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク Non-antibacterial tetracycline composition
EP1009390A4 (en) 1997-07-02 2004-05-06 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
WO1999009982A1 (en) 1997-08-25 1999-03-04 Harold Brem Prevention of adhesions and excessive scar formation using angiogenesis inhibitors
AU2001599A (en) * 1997-12-19 1999-07-05 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
CA2320202C (en) * 1998-02-13 2010-09-14 Nutramax Laboratories, Inc. Agents and methods for protection, treatment and repair of connective tissue
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
DE29923766U1 (en) * 1998-05-27 2001-06-07 Euroceltique S.A., Luxemburg/Luxembourg Drug delivery system comprising a highly compressed solid drug supply
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
US6673843B2 (en) 1999-06-30 2004-01-06 Emory University Curcumin and curcuminoid inhibition of angiogenesis
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7211267B2 (en) * 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
CA2447008A1 (en) * 2001-04-05 2002-10-24 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332546A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
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AU2003296482A1 (en) * 2002-12-13 2004-07-09 The Research Foundation Of State University Of New York Tetracyclines as anti-fungal agents for treatment of ringworm
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BRPI0602372B8 (en) 2006-05-18 2021-06-22 Einco Biomaterial Ltda process for preparing composites based on bioceramics and biodegradable polymers and derived products
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AU2007338681B2 (en) * 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
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Also Published As

Publication number Publication date
JP2676080B2 (en) 1997-11-12
DK62286A (en) 1986-08-08
DK174997B1 (en) 2004-04-13
US4704383A (en) 1987-11-03
CA1297410C (en) 1992-03-17
ZA86838B (en) 1986-10-29
IE58813B1 (en) 1993-11-17
GR860333B (en) 1986-06-13
JPS61243023A (en) 1986-10-29
EP0195906B1 (en) 1992-10-14
AU5298486A (en) 1986-08-14
EP0195906A2 (en) 1986-10-01
ES551701A0 (en) 1987-10-01
DE3686956T2 (en) 1993-05-06
IE860333L (en) 1986-08-07
DK62286D0 (en) 1986-02-07
ATE81460T1 (en) 1992-10-15
EP0195906A3 (en) 1988-10-19
DE3686956D1 (en) 1992-11-19
AU583884B2 (en) 1989-05-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060711