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ES8707549A1 - Substituted peptide compounds - Google Patents

Substituted peptide compounds

Info

Publication number
ES8707549A1
ES8707549A1 ES539083A ES539083A ES8707549A1 ES 8707549 A1 ES8707549 A1 ES 8707549A1 ES 539083 A ES539083 A ES 539083A ES 539083 A ES539083 A ES 539083A ES 8707549 A1 ES8707549 A1 ES 8707549A1
Authority
ES
Spain
Prior art keywords
formula
compound
peptide compounds
substituted peptide
amicetone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539083A
Other languages
Spanish (es)
Other versions
ES539083A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8707549A1 publication Critical patent/ES8707549A1/en
Publication of ES539083A0 publication Critical patent/ES539083A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS PEPTIDICOS SUSTITUIDOS. COMPRENDE: A) OBTENER LA AMICETONA DE FORMULA (II) POR CONVERSION DE LA CARBOXIALQUILAMINA DE FORMULA (VI), EN SU CLORURO DE ACIDO Y REACCION POSTERIOR CON UNA OXAZOLONA PARA DAR UN COMPUESTO DE FORMULA (VII) Y SEPARAR EL GRUPO PROTECTOR R40 POR HIDROGENACION. SIENDO: R, H, ALQUILO INFERIOR Y OTROS; R2 ES UN COMPUESTO DE FORMULA (V) Y OTROS; R3 ES H, ALCOHILO INFERIOR Y OTROS; R40 ES UN GRUPO PROTECTOR; Y B) HACER REACCIONAR UNA AMICETONA DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: HALO, EL, BR; R1, R6 Y R7 IGUAL QUE R; R14 ES H, ALQUILO INFERIOR DE C 1 A4, Y OTROS; X ES UN GRUPO PROTECTOR DE ESTER; M ES 0 A 4; Y P, 1 A 3. SE UTILIZAN PARA REDUCIR LA HIPERTENSION RELACIONADA CON LAS ANGIOTENSINAS.PROCEDURE FOR PREPARING SUBSTITUTED PEPTIDE COMPOUNDS. IT INCLUDES: A) OBTAIN AMICETONE FROM FORMULA (II) BY CONVERSION OF THE CARBOXIALKYLAMINE FROM FORMULA (VI), INTO ITS ACID CHLORIDE AND SUBSEQUENT REACTION WITH AN OXAZOLONE TO GIVE A COMPOUND OF FORMULA (VII) AND SEPARATE THE R40 BY GROUP HYDROGENATION. BEING: R, H, LOWER RENT AND OTHERS; R2 IS A COMPOUND OF FORMULA (V) AND OTHERS; R3 IS H, LOWER ALCOHYL, AND OTHERS; R40 IS A PROTECTIVE GROUP; AND B) REACTING AN AMICETONE OF FORMULA (II) WITH A COMPOUND OF FORMULA (III) TO OBTAIN A COMPOUND OF FORMULA (I) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. BEING: HALO, EL, BR; R1, R6 AND R7 SAME AS R; R14 IS H, LOWER ALKYL OF C 1 A4, AND OTHERS; X IS A PROTECTIVE GROUP OF ESTHER; M IS 0 TO 4; AND P, 1 TO 3. ARE USED TO REDUCE ANGIOTENSIN-RELATED HYPERTENSION.

ES539083A 1982-07-19 1984-12-27 Substituted peptide compounds Expired ES8707549A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
ES8707549A1 true ES8707549A1 (en) 1986-04-01
ES539083A0 ES539083A0 (en) 1986-04-01

Family

ID=23580391

Family Applications (4)

Application Number Title Priority Date Filing Date
ES83524200A Expired ES8504675A1 (en) 1982-07-19 1983-07-18 Substituted peptide compounds
ES539083A Expired ES8707549A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds
ES539084A Expired ES8707550A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds
ES539082A Expired ES8707548A1 (en) 1982-07-19 1984-12-27 A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES83524200A Expired ES8504675A1 (en) 1982-07-19 1983-07-18 Substituted peptide compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES539084A Expired ES8707550A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds
ES539082A Expired ES8707548A1 (en) 1982-07-19 1984-12-27 A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS

Country Status (21)

Country Link
JP (3) JPS5951246A (en)
KR (1) KR840005709A (en)
AU (1) AU1643283A (en)
BE (1) BE897327A (en)
CA (1) CA1244006A (en)
CH (1) CH659475A5 (en)
DE (1) DE3325850A1 (en)
DK (1) DK330683A (en)
ES (4) ES8504675A1 (en)
FI (1) FI832620L (en)
FR (3) FR2530238B1 (en)
GB (1) GB2123834B (en)
GR (1) GR79602B (en)
HU (1) HU187090B (en)
IE (1) IE55818B1 (en)
IL (1) IL69136A0 (en)
IT (1) IT1163800B (en)
NL (1) NL8302562A (en)
PT (1) PT77045B (en)
SE (1) SE8304031L (en)
ZA (1) ZA834980B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
IL76345A (en) * 1984-09-12 1988-12-30 Usv Pharma Corp Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (en) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Process for the Preparation of Remin Inhibitors Using 2- (L-Alayl-L-Histidylamino) -butanol Derivatives
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3505358A1 (en) 2017-01-10 2019-07-03 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (en) * 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (en) * 1980-09-17 1984-07-12 Univ Miami
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
EP0054862B1 (en) * 1980-12-18 1985-11-27 Schering Corporation Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
ES539082A0 (en) 1986-05-16
IT1163800B (en) 1987-04-08
HUT34040A (en) 1985-01-28
IE55818B1 (en) 1991-01-30
GB8318492D0 (en) 1983-08-10
FR2530238A1 (en) 1984-01-20
FR2530238B1 (en) 1989-06-30
IT8322114A0 (en) 1983-07-18
DK330683D0 (en) 1983-07-18
ES8707548A1 (en) 1986-05-16
JPH0532601A (en) 1993-02-09
NL8302562A (en) 1984-02-16
JPH0526775B2 (en) 1993-04-19
IL69136A0 (en) 1983-10-31
IE831655L (en) 1984-01-19
ES8707550A1 (en) 1986-04-01
PT77045A (en) 1983-08-01
ES539084A0 (en) 1986-04-01
JPH0645582B2 (en) 1994-06-15
CA1244006A (en) 1988-11-01
DK330683A (en) 1984-01-20
FR2540866A1 (en) 1984-08-17
GR79602B (en) 1984-10-31
AU1643283A (en) 1984-01-26
BE897327A (en) 1984-01-19
CH659475A5 (en) 1987-01-30
HU187090B (en) 1985-11-28
ES539083A0 (en) 1986-04-01
ZA834980B (en) 1984-03-28
ES524200A0 (en) 1985-04-16
DE3325850A1 (en) 1984-01-19
PT77045B (en) 1986-02-12
ES8504675A1 (en) 1985-04-16
FI832620A0 (en) 1983-07-19
GB2123834A (en) 1984-02-08
FR2540867A1 (en) 1984-08-17
JPH0653713B2 (en) 1994-07-20
FI832620L (en) 1984-01-20
SE8304031D0 (en) 1983-07-18
FR2540867B1 (en) 1987-07-31
JPH0517420A (en) 1993-01-26
JPS5951246A (en) 1984-03-24
SE8304031L (en) 1984-03-30
GB2123834B (en) 1986-10-22
KR840005709A (en) 1984-11-16

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