ES8703402A1 - Procedimiento para la obtencion de nuevos derivados del acido benzoico - Google Patents
Procedimiento para la obtencion de nuevos derivados del acido benzoicoInfo
- Publication number
- ES8703402A1 ES8703402A1 ES553731A ES553731A ES8703402A1 ES 8703402 A1 ES8703402 A1 ES 8703402A1 ES 553731 A ES553731 A ES 553731A ES 553731 A ES553731 A ES 553731A ES 8703402 A1 ES8703402 A1 ES 8703402A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical preparations
- compounds
- represent
- acid derivatives
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMOIENTO PARA LA OBTENCION DE NUEVOS DERIVADOS DEL ACIDO BENZOICO, ASI COMO SUS SALES FARMACEUTICAMENTE COMPATIBLES DE ESTOS ESTERES BASICOS CON ACIDOS. CONSISTE EN HACER REACCIONAR A UNA TEMPERATURA COMPRENDIDA ENTRE C80 Y 50 GRADOS EN UN DISOLVENTE APROTICO, ESPECIALMENTE EN UN DISOLVENTE DIPOLAR APROTICO, Y EN PRESENCIA DE CANTIDADES CATALITICAS DE UNA SAL DE COBRE, UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE A Y E SIGNIFICAN -CFC-; B Y D SIGNIFICAN -CH2-CH2-; R1 SIGNIFICA HIDROGENO, METILO O ETILO; R2 SIGNIFICA HIDROGENO O UN RESTO ALQUILO DE CADENA LINEAL CON 1 A 6 ATOMOS DE CARBONO; R11 REPRESENTA UN GRUPO PROTECTOR DESDOBLABLE; Y R12 SIGNIFICA UN ATOMO DE BROMO O DE YODO, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE ME REPRESENTA UN ATOMO DE LITIO. DE APLICACION EN TERAPEUTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853515278 DE3515278A1 (de) | 1985-04-27 | 1985-04-27 | Neue benzoesaeurederivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8703402A1 true ES8703402A1 (es) | 1987-02-16 |
| ES553731A0 ES553731A0 (es) | 1987-02-16 |
Family
ID=6269293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES553731A Expired ES8703402A1 (es) | 1985-04-27 | 1986-04-04 | Procedimiento para la obtencion de nuevos derivados del acido benzoico |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0199985A3 (es) |
| JP (1) | JPS6242947A (es) |
| KR (1) | KR860008155A (es) |
| AU (1) | AU582433B2 (es) |
| DD (1) | DD250313A5 (es) |
| DE (1) | DE3515278A1 (es) |
| DK (1) | DK186286A (es) |
| ES (1) | ES8703402A1 (es) |
| FI (1) | FI861414A7 (es) |
| GR (1) | GR860442B (es) |
| HU (1) | HU196163B (es) |
| IL (1) | IL77989A (es) |
| PT (1) | PT82393B (es) |
| SU (1) | SU1450734A3 (es) |
| ZA (1) | ZA861490B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2642972B1 (fr) * | 1989-02-14 | 1994-08-05 | Inst Nat Sante Rech Med | Agents pour le diagnostic et le traitement des melanomes, derives halogenes aromatiques utilisables comme de tels agents et leur preparation |
| DE4023742A1 (de) * | 1990-07-26 | 1992-01-30 | Gruenenthal Gmbh | Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
| DE4120698A1 (de) * | 1991-06-22 | 1992-12-24 | Gruenenthal Gmbh | Substituierte phenoxyalkanole und deren ester, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5649336A (en) * | 1979-09-05 | 1981-05-02 | Glaxo Group Ltd | Phenol derivative* its manufacture and its use |
| US4331683A (en) * | 1980-10-29 | 1982-05-25 | Pfizer Inc. | Carboxamide compounds as SRS-A antagonists |
| EP0056172B1 (en) * | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| US4499299A (en) * | 1981-12-30 | 1985-02-12 | Ici Americas Inc. | Pharmaceutically active phenylcarboxylic acid derivatives |
| US4507498A (en) * | 1982-04-09 | 1985-03-26 | Hoffmann-La Roche Inc. | Phenoxycarboxylic acids |
| DE3228629A1 (de) * | 1982-07-31 | 1984-02-02 | Reifenrath, Rainer Richard Otto, Dr., 3104 Unterlüß | Pharmazeutisches erzeugnis zur behandlung der atemwege und verfahren zu seiner herstellung |
| IL69691A (en) * | 1982-09-23 | 1988-01-31 | Merck Frosst Canada Inc | Leukotriene antagonists,their preparation and pharmaceutical compositions containing them |
| DD242802A1 (de) * | 1983-02-28 | 1987-02-11 | Univ Berlin Humboldt | Verfahren zur herstellung neuer w(2'-naphthoxy)-hydroxamsaeuren enthaltende pharmazeutische zubereitungen und ihren salzen |
| US4539419A (en) * | 1983-05-02 | 1985-09-03 | Hoffmann-La Roche Inc. | Naphthalenyloxy substituted carboxylic acids |
| US4499295A (en) * | 1983-05-09 | 1985-02-12 | G. D. Searle & Co. | Protease inhibitors |
-
1985
- 1985-04-27 DE DE19853515278 patent/DE3515278A1/de not_active Withdrawn
-
1986
- 1986-02-14 GR GR860442A patent/GR860442B/el unknown
- 1986-02-25 IL IL77989A patent/IL77989A/xx unknown
- 1986-02-27 ZA ZA861490A patent/ZA861490B/xx unknown
- 1986-03-24 EP EP86104007A patent/EP0199985A3/de not_active Withdrawn
- 1986-04-01 FI FI861414A patent/FI861414A7/fi not_active Application Discontinuation
- 1986-04-04 ES ES553731A patent/ES8703402A1/es not_active Expired
- 1986-04-08 SU SU864027236A patent/SU1450734A3/ru active
- 1986-04-15 PT PT82393A patent/PT82393B/pt unknown
- 1986-04-18 AU AU56366/86A patent/AU582433B2/en not_active Expired - Fee Related
- 1986-04-23 DK DK186286A patent/DK186286A/da not_active Application Discontinuation
- 1986-04-24 DD DD86289588A patent/DD250313A5/de unknown
- 1986-04-25 HU HU861716A patent/HU196163B/hu not_active IP Right Cessation
- 1986-04-25 JP JP61095006A patent/JPS6242947A/ja active Pending
- 1986-04-26 KR KR1019860003288A patent/KR860008155A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL77989A (en) | 1989-08-15 |
| SU1450734A3 (ru) | 1989-01-07 |
| PT82393A (de) | 1986-05-01 |
| EP0199985A2 (de) | 1986-11-05 |
| EP0199985A3 (de) | 1988-06-22 |
| HU196163B (en) | 1988-10-28 |
| DE3515278A1 (de) | 1986-10-30 |
| FI861414A0 (fi) | 1986-04-01 |
| HUT40611A (en) | 1987-01-28 |
| PT82393B (de) | 1987-09-10 |
| ES553731A0 (es) | 1987-02-16 |
| KR860008155A (ko) | 1986-11-12 |
| GR860442B (en) | 1986-06-16 |
| FI861414A7 (fi) | 1986-10-28 |
| AU582433B2 (en) | 1989-03-23 |
| DD250313A5 (de) | 1987-10-08 |
| DK186286D0 (da) | 1986-04-23 |
| JPS6242947A (ja) | 1987-02-24 |
| AU5636686A (en) | 1986-11-06 |
| ZA861490B (en) | 1986-10-29 |
| DK186286A (da) | 1986-10-28 |
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