ES8703135A1 - Tri-substd. ambroxyl deriv. prepn. - Google Patents
Tri-substd. ambroxyl deriv. prepn.Info
- Publication number
- ES8703135A1 ES8703135A1 ES554638A ES554638A ES8703135A1 ES 8703135 A1 ES8703135 A1 ES 8703135A1 ES 554638 A ES554638 A ES 554638A ES 554638 A ES554638 A ES 554638A ES 8703135 A1 ES8703135 A1 ES 8703135A1
- Authority
- ES
- Spain
- Prior art keywords
- ambroxyl
- deriv
- substd
- prepn
- tri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical class NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- WOGITNXCNOTRLK-VOTSOKGWSA-N (e)-3-phenylprop-2-enoyl chloride Chemical compound ClC(=O)\C=C\C1=CC=CC=C1 WOGITNXCNOTRLK-VOTSOKGWSA-N 0.000 abstract 1
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 229960005174 ambroxol Drugs 0.000 abstract 1
- 229960000985 ambroxol hydrochloride Drugs 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
This invention relates to a process for the preparation of ambroxol derivatives, these being obtained by reaction in a medium such as pyridine or an inert solvent for ambroxol or ambroxol hydrochloride with 2-tenoyl chloride and cinnamoyl chloride in a ratio of 1 to 3 moles respectively, yielding the corresponding trisubstituted ambroxol derivatives.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES554638A ES8703135A1 (en) | 1986-05-03 | 1986-05-03 | Tri-substd. ambroxyl deriv. prepn. |
| PT82738A PT82738B (en) | 1986-05-03 | 1986-06-09 | PREPARATION PROCESS OF AMBROXOL DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES554638A ES8703135A1 (en) | 1986-05-03 | 1986-05-03 | Tri-substd. ambroxyl deriv. prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8703135A1 true ES8703135A1 (en) | 1987-02-16 |
| ES554638A0 ES554638A0 (en) | 1987-02-16 |
Family
ID=8491225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554638A Expired ES8703135A1 (en) | 1986-05-03 | 1986-05-03 | Tri-substd. ambroxyl deriv. prepn. |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES8703135A1 (en) |
| PT (1) | PT82738B (en) |
-
1986
- 1986-05-03 ES ES554638A patent/ES8703135A1/en not_active Expired
- 1986-06-09 PT PT82738A patent/PT82738B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT82738B (en) | 1988-04-21 |
| PT82738A (en) | 1986-07-01 |
| ES554638A0 (en) | 1987-02-16 |
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