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ES8603871A1 - Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina - Google Patents

Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina

Info

Publication number
ES8603871A1
ES8603871A1 ES544205A ES544205A ES8603871A1 ES 8603871 A1 ES8603871 A1 ES 8603871A1 ES 544205 A ES544205 A ES 544205A ES 544205 A ES544205 A ES 544205A ES 8603871 A1 ES8603871 A1 ES 8603871A1
Authority
ES
Spain
Prior art keywords
pyrrolidines
methylenedioxy
hydroxybenzyl
phenethyl
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544205A
Other languages
English (en)
Other versions
ES544205A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/527,717 external-priority patent/US4543361A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES544205A0 publication Critical patent/ES544205A0/es
Publication of ES8603871A1 publication Critical patent/ES8603871A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-(FENETIL)-5-(3,4-METILENDIOXI)-A-HIDROXIBENCIL-PIRROLIDINA, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, SUS ENANTIOMEROS Y MEZCLAS RACEMICAS. CONSISTE EN LA REACCION DE CICLIZACION FORMADORA DE PIRROLIDINA DEL CORRESPONDIENTE COMPUESTO DE CADENA RECTA SUSTITUIDO CON EPOXIDO Y CON AMINO; SEGUIDA DE LA CONVERSION OPCIONAL DE LA BASE LIBRE EN SU SAL. LA REACCION SE LLEVA A CABO POR TRATAMIENTO CON UN EXCESO DE BASE FUERTE, LA DISOLUCION EN MEDIO ALCOHOL-AGUA, A LA TEMPERATURA DE REFLUJO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHIPERTENSIVOS.
ES544205A 1983-01-24 1985-06-14 Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina Expired ES8603871A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8300098 1983-01-24
US06/527,717 US4543361A (en) 1983-08-29 1983-08-29 ±2-[Phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine antihypertensives and use thereas

Publications (2)

Publication Number Publication Date
ES544205A0 ES544205A0 (es) 1986-01-16
ES8603871A1 true ES8603871A1 (es) 1986-01-16

Family

ID=26768103

Family Applications (3)

Application Number Title Priority Date Filing Date
ES529086A Granted ES529086A0 (es) 1983-01-24 1984-01-23 Procedimiento para preparar 2-(fenetil)-5-((3, 4-metilendioxi)- -hidroxibencil)-pirrolidina
ES544205A Expired ES8603871A1 (es) 1983-01-24 1985-06-14 Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina
ES544201A Expired ES8604210A1 (es) 1983-01-24 1985-06-14 Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES529086A Granted ES529086A0 (es) 1983-01-24 1984-01-23 Procedimiento para preparar 2-(fenetil)-5-((3, 4-metilendioxi)- -hidroxibencil)-pirrolidina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544201A Expired ES8604210A1 (es) 1983-01-24 1985-06-14 Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina

Country Status (10)

Country Link
EP (1) EP0115413A1 (es)
JP (2) JPS59161380A (es)
AU (1) AU2369984A (es)
DK (1) DK30184A (es)
ES (3) ES529086A0 (es)
FI (1) FI840255L (es)
IE (1) IE840151L (es)
IL (1) IL70753A0 (es)
NO (1) NO840241L (es)
ZA (2) ZA84507B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0562185A1 (en) * 1992-03-17 1993-09-29 Council of Scientific and Industrial Research 3-(Arylmethyl)-1-(3'-diethylaminopropyl) pyrrolidines and process of preparation thereof
JPH061371A (ja) * 1992-06-17 1994-01-11 Uintetsuku Kk ストレッチフィルム包装の開披容易化法とその装置
US6015824A (en) * 1998-02-10 2000-01-18 Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU78625A1 (de) * 1977-12-02 1979-06-13 Byk Gulden Lomberg Chem Fab Substituierte 1-phenyl-2-pyrrolidin-2-yl-ethanole,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel
FR2436779A1 (fr) * 1978-09-22 1980-04-18 Pharmindustrie Derives de pyrrolidine-2 methanol utilisables comme medicaments
FR2460929A1 (fr) * 1979-07-06 1981-01-30 Roussel Uclaf Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant
US4342692A (en) * 1980-10-20 1982-08-03 Usv Pharmaceutical Corporation Pyrrolidines
DK328382A (da) * 1981-07-22 1983-01-23 Syntex Inc Fremgangsmaade til fremstilling af antihypertensive midler

Also Published As

Publication number Publication date
DK30184D0 (da) 1984-01-23
FI840255A0 (fi) 1984-01-23
AU2369984A (en) 1984-07-26
ES8604210A1 (es) 1986-02-01
NO840241L (no) 1984-07-25
ZA84507B (en) 1985-09-25
ES544205A0 (es) 1986-01-16
IE840151L (en) 1985-02-28
ZA84508B (en) 1985-09-25
DK30184A (da) 1984-07-25
JPS59161380A (ja) 1984-09-12
FI840255A7 (fi) 1984-07-25
IL70753A0 (en) 1984-04-30
ES8600759A1 (es) 1985-11-01
FI840255L (fi) 1984-07-25
ES544201A0 (es) 1986-02-01
JPS59161381A (ja) 1984-09-12
ES529086A0 (es) 1985-11-01
EP0115413A1 (en) 1984-08-08

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