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ES8600269A1 - A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE SALT OF THE ACID S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO - Google Patents

A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE SALT OF THE ACID S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO

Info

Publication number
ES8600269A1
ES8600269A1 ES534920A ES534920A ES8600269A1 ES 8600269 A1 ES8600269 A1 ES 8600269A1 ES 534920 A ES534920 A ES 534920A ES 534920 A ES534920 A ES 534920A ES 8600269 A1 ES8600269 A1 ES 8600269A1
Authority
ES
Spain
Prior art keywords
crystalline salt
ureidocroman
fluor
preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534920A
Other languages
Spanish (es)
Other versions
ES534920A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/440,657 external-priority patent/US4431828A/en
Priority claimed from US06/440,641 external-priority patent/US4435578A/en
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES534920A0 publication Critical patent/ES534920A0/en
Publication of ES8600269A1 publication Critical patent/ES8600269A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO MEJORADO PARA LA PREPARACION DE UNA SAL CRISTALINA DEL ACIDO S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO.CONSISTENTE EN: COMBINAR UN COMPUESTO RACEMICO DE FORMULA (I) CON UNA CANTIDAD SEMIMOLAR DE D-(B)-(1-FENE-TIL) AMINA O DE L-(C)-EFEDRINA, EN UN DISOLVENTE INERTE A LA REACCION Y RECUPERAR LA SAL CRISTALINA, PARA PREPARAR UNA SAL CRISTALINA DEL ACIDO S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO, CON D-(B)-(1-FENETRAL) AMINA O CON L-(C)-EFEDRINA.IMPROVED PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE SALT OF S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXYL ACID, CONSISTING OF: COMBINING A RACEMIC COMPOUND OF FORMULA (I) WITH A SEMIMOLAR QUANTITY OF D- (B) - (1 -FENE-TIL) AMINE OR OF L- (C) -EPHEDRINE, IN A SOLVENT INERT TO THE REACTION AND RECOVER THE CRYSTALLINE SALT, TO PREPARE A CRYSTALLINE SALT OF THE S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXYL ACID, WITH D- (B) - (1-FENETRAL) AMINE OR WITH L- (C) -EPHEDRINE.

ES534920A 1982-11-10 1984-08-06 A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE SALT OF THE ACID S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO Expired ES8600269A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44068682A 1982-11-10 1982-11-10
US06/440,657 US4431828A (en) 1982-11-10 1982-11-10 Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
US06/440,641 US4435578A (en) 1982-11-10 1982-11-10 Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid

Publications (2)

Publication Number Publication Date
ES534920A0 ES534920A0 (en) 1985-09-16
ES8600269A1 true ES8600269A1 (en) 1985-09-16

Family

ID=27412063

Family Applications (3)

Application Number Title Priority Date Filing Date
ES527118A Expired ES8506040A1 (en) 1982-11-10 1983-11-08 A PROCEDURE FOR THE PREPARATION OF SORBINYL OR A PHARMACEUTICALLY ACCEPTABLE CATIONIC SALT.
ES534921A Expired ES8505988A1 (en) 1982-11-10 1984-08-06 A PROCEDURE FOR REGENERATION OF PURIFIED 6-FLUOR-4-CHROMANONE
ES534920A Expired ES8600269A1 (en) 1982-11-10 1984-08-06 A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE SALT OF THE ACID S-6-FLUOR-4-UREIDOCROMAN-4-CARBOXILICO

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES527118A Expired ES8506040A1 (en) 1982-11-10 1983-11-08 A PROCEDURE FOR THE PREPARATION OF SORBINYL OR A PHARMACEUTICALLY ACCEPTABLE CATIONIC SALT.
ES534921A Expired ES8505988A1 (en) 1982-11-10 1984-08-06 A PROCEDURE FOR REGENERATION OF PURIFIED 6-FLUOR-4-CHROMANONE

Country Status (16)

Country Link
KR (1) KR870000867B1 (en)
AU (1) AU540399B2 (en)
BG (1) BG44206A3 (en)
CS (1) CS266560B2 (en)
DD (1) DD213924A5 (en)
DK (1) DK512683A (en)
ES (3) ES8506040A1 (en)
FI (1) FI77247C (en)
GR (1) GR79017B (en)
IL (2) IL70165A (en)
NO (1) NO161916C (en)
NZ (1) NZ206189A (en)
PL (1) PL139713B1 (en)
PT (1) PT77617B (en)
SU (1) SU1209030A3 (en)
YU (2) YU44867B (en)

Also Published As

Publication number Publication date
NO834086L (en) 1984-05-11
IL81648A0 (en) 1987-09-16
PT77617A (en) 1983-12-01
NO161916C (en) 1989-10-11
KR870000867B1 (en) 1987-04-30
GR79017B (en) 1984-10-02
KR840006806A (en) 1984-12-03
PL139713B1 (en) 1987-02-28
IL70165A0 (en) 1984-02-29
YU220383A (en) 1988-02-29
DK512683D0 (en) 1983-11-09
ES534921A0 (en) 1985-06-16
AU2110583A (en) 1984-05-17
CS827183A2 (en) 1989-04-14
YU140985A (en) 1986-04-30
CS266560B2 (en) 1990-01-12
FI77247B (en) 1988-10-31
NO161916B (en) 1989-07-03
FI834088L (en) 1984-05-11
NZ206189A (en) 1987-06-30
ES534920A0 (en) 1985-09-16
SU1209030A3 (en) 1986-01-30
AU540399B2 (en) 1984-11-15
ES527118A0 (en) 1985-06-16
YU43883B (en) 1989-12-31
IL70165A (en) 1987-12-20
PT77617B (en) 1986-05-12
PL244460A1 (en) 1985-03-26
ES8506040A1 (en) 1985-06-16
YU44867B (en) 1991-04-30
DK512683A (en) 1984-05-11
BG44206A3 (en) 1988-10-14
ES8505988A1 (en) 1985-06-16
FI834088A0 (en) 1983-11-08
DD213924A5 (en) 1984-09-26
FI77247C (en) 1989-02-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303