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ES8504722A1 - Un metodo de preparar derivados de 4-quinolona - Google Patents

Un metodo de preparar derivados de 4-quinolona

Info

Publication number
ES8504722A1
ES8504722A1 ES530015A ES530015A ES8504722A1 ES 8504722 A1 ES8504722 A1 ES 8504722A1 ES 530015 A ES530015 A ES 530015A ES 530015 A ES530015 A ES 530015A ES 8504722 A1 ES8504722 A1 ES 8504722A1
Authority
ES
Spain
Prior art keywords
chain length
carbon chain
lower alkyl
hydrogen
stands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530015A
Other languages
English (en)
Other versions
ES530015A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES530015A0 publication Critical patent/ES530015A0/es
Publication of ES8504722A1 publication Critical patent/ES8504722A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE 4-QUINOLONA.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA (II) CON UN COMPUESTO DE FORMULA ZCHO, PARA OBTENER DERIVADOS DE 4-QUINOLONA DE FORMULA (I), DONDE R Y R SON H, ALQUILO C 1 A 8 O ALQUENILO C 1 A 4; R ES H, ALQUILO C 1 A 8 Y OTROS; Z ES FENILO CON O SIN SUSTITUYENTES TALES COMO H, HALOGENO, ALQUILO C 1 A 8 Y OTROS. LA REACCION SE LLEVA A CABO ENTRE 50 Y 200JC DURANTE 30 MINUTOS A 10 HORAS Y EN PRESENCIA DE DISOLVENTES COMO DIOXANO, TOLUENO Y OTROS.PRESENTAN ACCION ANTIALERGICA, EXPECTORANTE E INHIBIDORA DE LA COAGULACION DE PLAQUETAS, SIENDO UTILES COMO MEDICAMENTOS ANTIALERGICOS, ANTITUSIVOS, ANTITROMBOTICOS Y PARA EL ASMA.
ES530015A 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona Expired ES8504722A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57102592A JPS58219166A (ja) 1982-06-14 1982-06-14 ４−キノロン誘導体

Publications (2)

Publication Number Publication Date
ES530015A0 ES530015A0 (es) 1985-05-01
ES8504722A1 true ES8504722A1 (es) 1985-05-01

Family

ID=14331501

Family Applications (5)

Application Number Title Priority Date Filing Date
ES523190A Granted ES523190A0 (es) 1982-06-14 1983-06-13 Un metodo de preparar derivados de 4-quinolona
ES530013A Granted ES530013A0 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona
ES530015A Expired ES8504722A1 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona
ES530012A Granted ES530012A0 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona
ES530014A Expired ES8504721A1 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES523190A Granted ES523190A0 (es) 1982-06-14 1983-06-13 Un metodo de preparar derivados de 4-quinolona
ES530013A Granted ES530013A0 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES530012A Granted ES530012A0 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona
ES530014A Expired ES8504721A1 (es) 1982-06-14 1984-02-24 Un metodo de preparar derivados de 4-quinolona

Country Status (7)

Country Link
US (1) US4711898A (es)
EP (1) EP0104959B1 (es)
JP (1) JPS58219166A (es)
KR (1) KR900006118B1 (es)
CA (1) CA1244436A (es)
DE (1) DE3369316D1 (es)
ES (5) ES523190A0 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910327A (en) * 1982-05-25 1990-03-20 American Cyanamid Company Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid: dialkyl 3-(substituted)phenylaminobut-2-ene-dioates and methods for the preparation thereof
US5138088A (en) * 1988-06-17 1992-08-11 Korea Advanced Institute Of Science And Technology Nitrobenzoyl-3-cyclopropylaminoacrylates and a process for the preparation thereof
KR910003634B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 니트로벤조일-3-시클로프로필아미노아크릴레이트 및 그 제조방법
FR2684671B1 (fr) * 1991-11-20 1995-05-19 Roussel Uclaf Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments.
FR2672597B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2680511B1 (fr) * 1991-08-20 1995-05-19 Roussel Uclaf Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
DE60013994T2 (de) * 1999-08-30 2005-10-06 Maruishi Pharmaceutical Co.Ltd. 1,2-Disubstituierte 1,4-Dihydro-4-oxochinolin-Verbindungen
US20050224398A1 (en) * 2001-10-19 2005-10-13 Largent David W Vibratory separators and sealing screens
US11638705B2 (en) * 2019-04-19 2023-05-02 Academia Sinica 4(1H)-quinolone derivatives and uses thereof
US11938127B2 (en) 2021-09-28 2024-03-26 Wayne State University Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders
WO2023078252A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785165A (en) * 1953-12-22 1957-03-12 Abbott Lab Preparation of 4-aminoquinoline
FR1202105A (fr) * 1956-06-14 1960-01-07 Basf Ag Procédé pour la production de quinolones-4 comportant un groupe hydoxyle sur le noyau benzénique
CH560193A5 (es) * 1968-06-14 1975-03-27 Ciba Geigy Ag
HU167910B (es) * 1972-11-22 1976-01-28
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
US4049715A (en) * 1973-10-01 1977-09-20 Sterling Drug Inc. 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols
DE2910195A1 (de) * 1979-03-15 1980-09-25 Hoechst Ag 2-(4-aminopiperidino)-3,4-dihydrochinoline und verfahren zu ihrer herstellung
ATE27451T1 (de) * 1981-03-24 1987-06-15 Ciba Geigy Ag Acyl-chinolinonderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung.

Also Published As

Publication number Publication date
JPH0310621B2 (es) 1991-02-14
KR900006118B1 (ko) 1990-08-22
DE3369316D1 (en) 1987-02-26
EP0104959A1 (en) 1984-04-04
ES530014A0 (es) 1985-05-01
KR840005100A (ko) 1984-11-03
JPS58219166A (ja) 1983-12-20
CA1244436A (en) 1988-11-08
ES8504721A1 (es) 1985-05-01
ES8503333A1 (es) 1985-02-16
EP0104959B1 (en) 1987-01-21
ES530015A0 (es) 1985-05-01
ES8601897A1 (es) 1985-11-16
ES8600246A1 (es) 1985-10-01
ES530013A0 (es) 1985-11-16
US4711898A (en) 1987-12-08
ES523190A0 (es) 1985-02-16
ES530012A0 (es) 1985-10-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401