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ES8406067A1 - Un procedimiento de preparacion de un nuevo derivado de (2,4,6-trimetoxifenil)-(3-piperidinopropil)cetona - Google Patents

Un procedimiento de preparacion de un nuevo derivado de (2,4,6-trimetoxifenil)-(3-piperidinopropil)cetona

Info

Publication number
ES8406067A1
ES8406067A1 ES526735A ES526735A ES8406067A1 ES 8406067 A1 ES8406067 A1 ES 8406067A1 ES 526735 A ES526735 A ES 526735A ES 526735 A ES526735 A ES 526735A ES 8406067 A1 ES8406067 A1 ES 8406067A1
Authority
ES
Spain
Prior art keywords
trimethoxyphenyl
piperidinopropyl
preparation process
ketone derivatives
therapeutical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526735A
Other languages
English (en)
Other versions
ES526735A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of ES526735A0 publication Critical patent/ES526735A0/es
Publication of ES8406067A1 publication Critical patent/ES8406067A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN NUEVO DERIVADO DE (2,4,6-TRIMETOXIFENIL)-(3-PIPERIDINOPROPIL)CE TONA.CONSISTE EN PREPARAR COMPUESTOS DE FORMULA (I) Y SUS SALES DE ADICION DONDE R1 REPRESENTA UN GRUPO CH3 O C2H5 Y R2 REPRESENTA H, CH3 Y C2H5 Y EN EL PROCEDIMIENTO SE FORMA UN 4-(ALQUILPIPERIDINO) BUTIRONITRILO QUE SE CONDENSA CON 1,3,5-TRIMETOXIBENCENO Y SE HIDROLIZA EL DERIVADO CETIMINO RESULTANTE. SE HACE REACCIONAR UNA PIPERIDINA SUSTITUIDA DE FORMULA (II) DONDE R1SC Y R2 SON LOS DEFINIDOS ANTERIORMENTE CON 4-CLOROBUTIROMITRILO DE FORMULA CL(CH2)3-CN DURANTE 2 HORAS COMO MINIMO, A REFLUJO EN UN DISOLVENTESELECCIONADO ENTRE LOS HIDROCARBUROS AROMATICOS, PARA OBTENER EL 4-(ALQUILPIPERIDINO)BUTIRONIT RILO CORRESPONDIENTE DE FORMULA (III) DONDE R1 Y R2 SON LOS DEFINIDOS ANTERIORMENTE.POSEE PROPIEDADES VASODILATADORAS, HIPOTENSIVAS Y BRANDICARDIZANTES EN LOS TRASTORNOS CIRCULATORIOS.
ES526735A 1982-10-26 1983-10-25 Un procedimiento de preparacion de un nuevo derivado de (2,4,6-trimetoxifenil)-(3-piperidinopropil)cetona Expired ES8406067A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8217938A FR2534912B1 (fr) 1982-10-26 1982-10-26 Nouveaux derives de (2,4,6-trimethoxyphenyl) - (3-piperidinopropyl) -cetone, utilisation en therapeutique et procede de preparation

Publications (2)

Publication Number Publication Date
ES526735A0 ES526735A0 (es) 1984-07-01
ES8406067A1 true ES8406067A1 (es) 1984-07-01

Family

ID=9278618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526735A Expired ES8406067A1 (es) 1982-10-26 1983-10-25 Un procedimiento de preparacion de un nuevo derivado de (2,4,6-trimetoxifenil)-(3-piperidinopropil)cetona

Country Status (9)

Country Link
US (1) US4705795A (es)
EP (1) EP0110747B1 (es)
JP (1) JPS5995268A (es)
AT (1) ATE20053T1 (es)
AU (1) AU559517B2 (es)
CA (1) CA1215373A (es)
DE (1) DE3363802D1 (es)
ES (1) ES8406067A1 (es)
FR (1) FR2534912B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2597864B1 (fr) * 1986-04-28 1990-11-16 Lafon Labor Nouveaux derives de la n-((trimethoxy-2,4,6-benzoyl)-3 propyl) piperidine, leurs procedes de preparation et leur application en therapeutique
US6528529B1 (en) * 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
EP2155643B1 (en) 2007-06-08 2016-08-10 MannKind Corporation Ire-1a inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1115992A (en) * 1965-03-26 1968-06-06 Lafon Labor Improvements in or relating to n-piperidino-alkoxyacetophenones
FR5636M (es) * 1966-07-06 1967-12-18
DE1770721A1 (de) * 1967-06-28 1972-01-13 Takeda Chemical Industries Ltd Neue Piperidinderivate und Verfahren zu ihrer Herstellung
FR2092133B1 (es) * 1970-05-06 1974-03-22 Orsymonde
US4031101A (en) * 1976-04-15 1977-06-21 Parke, Davis & Company Cis-2,6-dimethyl-α,α-diphenyl-1-piperidinebutanol compounds
GB2004883B (en) * 1977-09-26 1982-03-17 Lafon Labor Phloroglucinol derivatives their method of preparation and their use as pharmaceuticals
EP0021592B1 (en) * 1979-05-23 1983-09-28 BEECHAM - WUELFING GmbH & Co. KG Phenylsulphonamide derivatives, a process for their preparation and their use as medicines
FR2504136A1 (fr) * 1981-04-15 1982-10-22 Lafon Labor (2,6-dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl)-cetone et ses sels d'addition, utilisation en therapeutique et procede de preparation

Also Published As

Publication number Publication date
ES526735A0 (es) 1984-07-01
DE3363802D1 (en) 1986-07-03
ATE20053T1 (de) 1986-06-15
US4705795A (en) 1987-11-10
EP0110747A2 (fr) 1984-06-13
EP0110747A3 (en) 1984-08-08
FR2534912B1 (fr) 1985-06-28
EP0110747B1 (fr) 1986-05-28
FR2534912A1 (fr) 1984-04-27
JPH0127063B2 (es) 1989-05-26
CA1215373A (en) 1986-12-16
AU559517B2 (en) 1987-03-12
AU2056783A (en) 1984-05-03
JPS5995268A (ja) 1984-06-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000503