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ES8405813A1 - Procedimiento para la preparacion de nuevas 7 -aciltio-1 ,2 -metilen-3-oxo-17 -pregn-4-en-21,17-carbolactonas - Google Patents

Procedimiento para la preparacion de nuevas 7 -aciltio-1 ,2 -metilen-3-oxo-17 -pregn-4-en-21,17-carbolactonas

Info

Publication number
ES8405813A1
ES8405813A1 ES526898A ES526898A ES8405813A1 ES 8405813 A1 ES8405813 A1 ES 8405813A1 ES 526898 A ES526898 A ES 526898A ES 526898 A ES526898 A ES 526898A ES 8405813 A1 ES8405813 A1 ES 8405813A1
Authority
ES
Spain
Prior art keywords
alpha
carbolactones
pregn
acylthio
ene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526898A
Other languages
English (en)
Other versions
ES526898A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES526898A0 publication Critical patent/ES526898A0/es
Publication of ES8405813A1 publication Critical patent/ES8405813A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS 7BAB-ACILTIO-1BAB,2BAB-METILEN-3-OXO-17BAB-PREGN-4 -EN-21,17-CARBOLACTONAS.CONSISTE EN LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (I), DONDESIGNIFICA LA AGRUPACIONCH2 OCH2 Y R SIGNIFICA UN RADICAL ACILO SATURADO CON 2 A 4 ATOMOS DE CARBONO EN EL QUE SE HACE REACCIONAR POR ADICION UN RADICAL ACILO R EN DONDE SIGNIFICA LA AGRUPACIONCH2 OCH2 UN ACIDO TIOCARBOXILICO DE FORMULA GENERAL (III), DONDE R SIGNIFICA UN RADICAL ACILO SATURADO, INFERIOR CON 2 A 4 ATOMOS DE CARBONO, A UNA TEMPERATURA DE 0 A 30J AL PUNTO DE EBULLICION EN UN DISOLVENTEPROTICO, POLAR.
ES526898A 1982-10-29 1983-10-28 Procedimiento para la preparacion de nuevas 7 -aciltio-1 ,2 -metilen-3-oxo-17 -pregn-4-en-21,17-carbolactonas Expired ES8405813A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823240510 DE3240510A1 (de) 1982-10-29 1982-10-29 Neue 7(alpha)-acylthio-1(alpha),2(alpha)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, deren herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES526898A0 ES526898A0 (es) 1984-07-01
ES8405813A1 true ES8405813A1 (es) 1984-07-01

Family

ID=6177150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526898A Expired ES8405813A1 (es) 1982-10-29 1983-10-28 Procedimiento para la preparacion de nuevas 7 -aciltio-1 ,2 -metilen-3-oxo-17 -pregn-4-en-21,17-carbolactonas

Country Status (10)

Country Link
US (1) US4511565A (es)
EP (1) EP0108033B1 (es)
JP (1) JPS5989700A (es)
AT (1) ATE31192T1 (es)
AU (1) AU556675B2 (es)
CA (1) CA1203233A (es)
DE (2) DE3240510A1 (es)
DK (1) DK496283A (es)
ES (1) ES8405813A1 (es)
IE (1) IE56178B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427090A1 (de) * 1984-07-19 1986-01-23 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-thiosubstituierte 19-hydroxy-15(beta),16(beta)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3506100A1 (de) * 1985-02-18 1986-08-21 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS6248694A (ja) * 1985-08-28 1987-03-03 Shionogi & Co Ltd 抗アルドステロン活性ステロイド誘導体
US20130123523A1 (en) * 2011-11-10 2013-05-16 Klaus Nickisch Methods for the preparation of etonogestrel and desogestrel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3753979A (en) * 1971-12-06 1973-08-21 Merck & Co Inc Substituted 1,2alpha-methylene-6,7alpha-halomethylene-20-spirox-4-en-3-ones or 3-ols and acyl esters thereof
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5842879B2 (ja) * 1979-05-14 1983-09-22 三菱化学株式会社 ステロイドカルボン酸塩の製造法
DE2922500A1 (de) * 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta

Also Published As

Publication number Publication date
ATE31192T1 (de) 1987-12-15
IE56178B1 (en) 1991-05-08
US4511565A (en) 1985-04-16
ES526898A0 (es) 1984-07-01
DK496283A (da) 1984-04-30
AU556675B2 (en) 1986-11-13
DK496283D0 (da) 1983-10-28
JPS5989700A (ja) 1984-05-23
DE3240510A1 (de) 1984-05-03
EP0108033A1 (de) 1984-05-09
IE832531L (en) 1984-04-29
DE3374784D1 (en) 1988-01-14
CA1203233A (en) 1986-04-15
JPH0436160B2 (es) 1992-06-15
EP0108033B1 (de) 1987-12-02
AU2069783A (en) 1984-05-03

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506