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ES8403157A1 - Un metodo de preparar sustancias biologicamente activas que tienen actividad anti-tumoral. - Google Patents

Un metodo de preparar sustancias biologicamente activas que tienen actividad anti-tumoral.

Info

Publication number
ES8403157A1
ES8403157A1 ES519737A ES519737A ES8403157A1 ES 8403157 A1 ES8403157 A1 ES 8403157A1 ES 519737 A ES519737 A ES 519737A ES 519737 A ES519737 A ES 519737A ES 8403157 A1 ES8403157 A1 ES 8403157A1
Authority
ES
Spain
Prior art keywords
active substance
biological active
cells
manufacturing biological
act
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519737A
Other languages
English (en)
Other versions
ES519737A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES519737A0 publication Critical patent/ES519737A0/es
Publication of ES8403157A1 publication Critical patent/ES8403157A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/91—Cell lines ; Processes using cell lines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

METODO PARA PREPARAR SUSTANCIAS BIOLOGICAMENTE ACTIVAS QUE TIENEN ACTIVIDAD ANTI-TUMORAL, QUE ACTUAN ESPECIFICAMENTE SOBRE LAS CELULAS DE CANCER SOLO, Y QUE NO ACTUAN SOBRE CELULAS NORMALES.CARACTERIZADO PORQUE SE CULTIVAN CELULAS DERIVADAS DE ANIMALES O CELULAS HIBRIDAS DE ELLOS, Y SE PURIFICA EL FLUIDO RESULTANTE QUE SOBRENADA EN EL CULTIVO; PORQUE DICHO CULTIVO SE EFECTUA USANDO UN LIQUIDO DE CULTIVO AL QUE SE AÑADE LIPOPOLISACARIDO O LIPIDO A O LIPOSOMA, LECTINA O UN INDUCTOR DE INTERFERON DEL MISMO; Y PORQUE LA PURIFICACION SE EFECTUA POR CROMATOGRAFIADE AFINIDAD, USANDO UN ANTICUERPO ESPECIFICO COMO AGENTE DE ADSORCION.
ES519737A 1982-02-13 1983-02-11 Un metodo de preparar sustancias biologicamente activas que tienen actividad anti-tumoral. Expired ES8403157A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57021562A JPS58138383A (ja) 1982-02-13 1982-02-13 生理活性物質の製法

Publications (2)

Publication Number Publication Date
ES519737A0 ES519737A0 (es) 1984-03-01
ES8403157A1 true ES8403157A1 (es) 1984-03-01

Family

ID=12058451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519737A Expired ES8403157A1 (es) 1982-02-13 1983-02-11 Un metodo de preparar sustancias biologicamente activas que tienen actividad anti-tumoral.

Country Status (5)

Country Link
EP (1) EP0087087A3 (es)
JP (1) JPS58138383A (es)
KR (1) KR840001836A (es)
CA (1) CA1201079A (es)
ES (1) ES8403157A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5933223A (ja) * 1982-08-20 1984-02-23 Koken Kk 人の悪性腫瘍細胞増殖抑制剤
JPS59162889A (ja) * 1983-03-07 1984-09-13 Koken Kk 人の悪性腫瘍細胞の増殖抑制剤の製造方法
JPS59204122A (ja) * 1983-05-06 1984-11-19 Koken Kk 人の悪性腫瘍細胞増殖抑制剤の製造方法
JPS6028930A (ja) * 1983-07-28 1985-02-14 Koken Kk 人の癌由来細胞の増殖抑制剤の精製方法
JPS6028931A (ja) * 1983-07-28 1985-02-14 Koken Kk ヒト腎細胞癌由来樹立株細胞の増殖抑制剤の濃縮方法
JPH088873B2 (ja) * 1983-07-28 1996-01-31 大日本製薬株式会社 ヒト癌壊死因子の製造法
JPS6043386A (ja) * 1983-08-20 1985-03-07 Koken Kk ヒト腎細胞癌由来樹立株細胞の増殖抑制剤の製造方法
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
US4959457A (en) * 1984-05-31 1990-09-25 Genentech, Inc. Anti-lymphotoxin
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6127923A (ja) * 1984-07-17 1986-02-07 Denichi Mizuno ヒト腫瘍壊死因子の製造法
IL73883A (en) † 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
JPS61155330A (ja) * 1984-12-28 1986-07-15 Denichi Mizuno 蛋白質標品
JPS6255087A (ja) * 1985-03-25 1987-03-10 シタス　オンコロジー　コーポレイション 融合蛋白質をコ−ドする組換ｄｎａ配列
GB2245415A (en) * 1990-06-22 1992-01-02 Philips Electronic Associated Infrared detector with a getter
US9416086B2 (en) * 2010-11-12 2016-08-16 Eastman Chemical Company Processes for purification of acid solutions
US9415366B2 (en) * 2012-12-31 2016-08-16 Eastman Chemical Company Systems and methods for processing variable acetyl streams

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865689A (en) * 1972-11-09 1975-02-11 Hoffmann La Roche Method of producing carcinoembryonic antigens
US4195017A (en) * 1975-02-25 1980-03-25 Samuel Bogoch Malignin, derived from brain tumor cells, complexes and polypeptides thereof
FR2302747B1 (fr) * 1975-03-03 1978-09-22 Inst Nat Sante Rech Med Procede d'obtention, a partir de macrophages de mammiferes, d'un produit therapeutique actif, notamment, a l'egard des cellules tumorales humaines et produit therapeutique ainsi obtenu
DE2600442A1 (de) * 1976-01-08 1977-07-14 Karl Dr Med Theurer Herstellung von biologischen arzneimitteln gegen maligne tumoren und blutkrankheiten aus zell- bzw. gewebekulturen
DE2619715A1 (de) * 1976-05-04 1977-11-24 Max Planck Gesellschaft Tumor-antigen und verfahren zu dessen herstellung
US4059486A (en) * 1976-11-03 1977-11-22 Monsanto Company Cell culture process
US4228236A (en) * 1978-05-15 1980-10-14 Northwestern University Process of producing carcinoembryonic antigen

Also Published As

Publication number Publication date
ES519737A0 (es) 1984-03-01
EP0087087A2 (en) 1983-08-31
CA1201079A (en) 1986-02-25
KR840001836A (ko) 1984-06-07
JPS58138383A (ja) 1983-08-17
EP0087087A3 (en) 1983-10-19

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