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ES8403121A1 - Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas. - Google Patents

Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas.

Info

Publication number
ES8403121A1
ES8403121A1 ES519528A ES519528A ES8403121A1 ES 8403121 A1 ES8403121 A1 ES 8403121A1 ES 519528 A ES519528 A ES 519528A ES 519528 A ES519528 A ES 519528A ES 8403121 A1 ES8403121 A1 ES 8403121A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
methyl
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519528A
Other languages
English (en)
Other versions
ES519528A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8403121A1 publication Critical patent/ES8403121A1/es
Publication of ES519528A0 publication Critical patent/ES519528A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIBENZODIAZEPINONAS SUSTITUIDAS, DE FORMULA GENERAL (I), EN LA QUE X SIGNIFICA UN ATOMO DE OXIGENO O EL GRUPO -NH-; Y R SIGNIFICA UN GRUPO 1-METIL-4-PIPERIDINILO O 4-METIL-1-PIPERAZINILO, EVENTUALMENTE SUSTITUIDO CON OTRO GRUPO METILO, Y SUS SALES DE ADICION DE ACIDOS CON ACIDOS INORGANICOS U ORGANICOS.CONSISTE EN HACER REACCIONAR UNA DIBENZODIAZEPINONA, DE FORMULA GENERAL (II), EN LA QUE Y SIGNIFICA UN ATOMO DE HALOGENO, PREFERENTEMENTE UN ATOMO DE CLORO O BROMO, CON UN COMPUESTO DE FORMULA: H -X - R O CON UN COMPUESTODE FORMULA: M - X - R.DE APLICACION COMO INHIBIDORES DE ULCERAS Y DE SECRECIONES DE ACIDOS GASTRICOS.
ES519528A 1982-02-06 1983-02-04 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas. Granted ES519528A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204158 DE3204158A1 (de) 1982-02-06 1982-02-06 "substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel"

Publications (2)

Publication Number Publication Date
ES8403121A1 true ES8403121A1 (es) 1984-03-01
ES519528A0 ES519528A0 (es) 1984-03-01

Family

ID=6155014

Family Applications (3)

Application Number Title Priority Date Filing Date
ES519528A Granted ES519528A0 (es) 1982-02-06 1983-02-04 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas.
ES526522A Expired ES8405784A1 (es) 1982-02-06 1983-10-17 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526521A Expired ES8405788A1 (es) 1982-02-06 1983-10-17 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES526522A Expired ES8405784A1 (es) 1982-02-06 1983-10-17 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526521A Expired ES8405788A1 (es) 1982-02-06 1983-10-17 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Country Status (9)

Country Link
US (1) US4443452A (es)
EP (1) EP0086980B1 (es)
JP (1) JPS58146574A (es)
AT (1) ATE17246T1 (es)
AU (1) AU557100B2 (es)
DE (2) DE3204158A1 (es)
ES (3) ES519528A0 (es)
NZ (1) NZ203194A (es)
ZA (1) ZA83773B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US9375100B2 (en) 2004-02-03 2016-06-28 Rtc Industries, Inc. Product securement and management system
CN114874140A (zh) * 2022-06-17 2022-08-09 吉林大学 一种具有丙烯酸酯结构的环亚胺衍生物及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795176C3 (de) * 1968-08-20 1974-10-24 Dr. Karl Thomae Gmbh, 7950 Biberach hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung
FI49509C (fi) * 1968-08-20 1975-07-10 Thomae Gmbh Dr K Menetelmä farmakologisesti vaikuttavien 5-asemaan substituoitujen 5,10 -dihydro-11H-dibentso/b,e//1,4/deatsepiini-11-onien ja niiden suolojen valmistamiseksi.
FI50242C (fi) * 1969-07-18 1976-01-12 Thomae Gmbh Dr K Menetelmä valmistaa farmakologisesti aktiivisia uusia diallyyliaminoal kanoyylidibenso- tai pyridobenso-diatsepiineja ja niiden happoadditios uoloja.
DE3028001A1 (de) * 1980-07-24 1982-02-18 Dr. Karl Thomae Gmbh, 7950 Biberach Neue, in 5-stellung substituierte 5,10-dihydro-11h-dibenzo (b,e)(1,4) diazepin-11-one, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Also Published As

Publication number Publication date
ES526522A0 (es) 1984-06-16
AU557100B2 (en) 1986-12-04
ES526521A0 (es) 1984-06-16
ZA83773B (en) 1984-10-31
NZ203194A (en) 1985-09-13
JPH0414112B2 (es) 1992-03-11
EP0086980B1 (de) 1986-01-02
ATE17246T1 (de) 1986-01-15
AU1112283A (en) 1983-08-11
US4443452A (en) 1984-04-17
DE3204158A1 (de) 1983-08-11
DE3361650D1 (en) 1986-02-13
ES519528A0 (es) 1984-03-01
JPS58146574A (ja) 1983-09-01
ES8405784A1 (es) 1984-06-16
EP0086980A1 (de) 1983-08-31
ES8405788A1 (es) 1984-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603