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ES8400731A1 - Procedimiento de preparacion de derivados de fenoxi-3-propanol-2- en forma de recematos. - Google Patents

Procedimiento de preparacion de derivados de fenoxi-3-propanol-2- en forma de recematos.

Info

Publication number
ES8400731A1
ES8400731A1 ES515588A ES515588A ES8400731A1 ES 8400731 A1 ES8400731 A1 ES 8400731A1 ES 515588 A ES515588 A ES 515588A ES 515588 A ES515588 A ES 515588A ES 8400731 A1 ES8400731 A1 ES 8400731A1
Authority
ES
Spain
Prior art keywords
derivatives
phenoxy
propanol
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515588A
Other languages
English (en)
Other versions
ES515588A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES515588A0 publication Critical patent/ES515588A0/es
Publication of ES8400731A1 publication Critical patent/ES8400731A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE FENOXI-3-PROPANOL-2, EN FORMA DE RACEMATOS.SE HACE REACCIONAR EL COMPUESTO (II) CON EPICLORHIDRINA PARA OBTENER EL COMPUESTO (II) QUE A CONTINUACION SE CONDENSA CON UNA AMINA RNH2 PARA OBTENER EL COMPUESTO (I) EN EL CUAL R. ES UN RADICAL CICLOALCOHILO DE 5 O 6 ATOMOS DE CARBONO; X ES OXIGENO O UN ENLACE Y R ES UN RADICAL ISOPROPILO.
ES515588A 1981-09-10 1982-09-09 Procedimiento de preparacion de derivados de fenoxi-3-propanol-2- en forma de recematos. Expired ES8400731A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8117137A FR2512443A1 (fr) 1981-09-10 1981-09-10 Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES515588A0 ES515588A0 (es) 1983-11-01
ES8400731A1 true ES8400731A1 (es) 1983-11-01

Family

ID=9262031

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515588A Expired ES8400731A1 (es) 1981-09-10 1982-09-09 Procedimiento de preparacion de derivados de fenoxi-3-propanol-2- en forma de recematos.
ES523719A Granted ES523719A0 (es) 1981-09-10 1983-06-30 Procedimiento de preparacion de derivados de fenoxi-3-propa nol-2,en forma de enantiomeros

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES523719A Granted ES523719A0 (es) 1981-09-10 1983-06-30 Procedimiento de preparacion de derivados de fenoxi-3-propa nol-2,en forma de enantiomeros

Country Status (15)

Country Link
US (1) US4515814A (es)
EP (1) EP0074873B1 (es)
JP (1) JPS5859947A (es)
AT (1) ATE10361T1 (es)
AU (1) AU553411B2 (es)
CA (1) CA1202984A (es)
DE (1) DE3261297D1 (es)
ES (2) ES8400731A1 (es)
FR (1) FR2512443A1 (es)
GR (1) GR77673B (es)
IE (1) IE53784B1 (es)
IL (1) IL66757A (es)
NZ (1) NZ201859A (es)
PT (1) PT75533B (es)
ZA (1) ZA826634B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
US4634713A (en) * 1982-05-28 1987-01-06 Ciba-Geigy Corporation Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives
GB8510146D0 (en) * 1985-04-20 1985-05-30 Smith Kline French Lab Chemical compounds & processes
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DE69714749T2 (de) * 1996-09-18 2003-04-24 Daiso Co., Ltd. Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern
CN115785058B (zh) * 2022-12-09 2024-05-03 广州康瑞泰药业有限公司 一种合成替格瑞洛五元环中间体的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
FR2409980A1 (fr) * 1977-11-24 1979-06-22 Synthelabo Ethers de phenols et leur application en therapeutique

Also Published As

Publication number Publication date
CA1202984A (en) 1986-04-08
IL66757A0 (en) 1982-12-31
ATE10361T1 (de) 1984-12-15
ZA826634B (en) 1983-07-27
GR77673B (es) 1984-09-25
US4515814A (en) 1985-05-07
ES8403854A1 (es) 1984-04-01
EP0074873A1 (fr) 1983-03-23
AU8816682A (en) 1983-03-31
FR2512443B1 (es) 1984-07-13
FR2512443A1 (fr) 1983-03-11
IE822214L (en) 1983-03-10
IL66757A (en) 1985-12-31
AU553411B2 (en) 1986-07-17
IE53784B1 (en) 1989-02-15
PT75533A (fr) 1982-10-01
PT75533B (fr) 1985-12-09
EP0074873B1 (fr) 1984-11-21
ES523719A0 (es) 1984-04-01
JPS5859947A (ja) 1983-04-09
ES515588A0 (es) 1983-11-01
DE3261297D1 (en) 1985-01-03
NZ201859A (en) 1985-05-31

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