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ES8302654A1 - "procedimiento para la preparacion de acido 1-(4-cloro-benzoilo)-5-metoxi-2-metilo-3-indolil-acetohidroxamico". - Google Patents

"procedimiento para la preparacion de acido 1-(4-cloro-benzoilo)-5-metoxi-2-metilo-3-indolil-acetohidroxamico".

Info

Publication number
ES8302654A1
ES8302654A1 ES511037A ES511037A ES8302654A1 ES 8302654 A1 ES8302654 A1 ES 8302654A1 ES 511037 A ES511037 A ES 511037A ES 511037 A ES511037 A ES 511037A ES 8302654 A1 ES8302654 A1 ES 8302654A1
Authority
ES
Spain
Prior art keywords
indolyl
benzoyl
chloro
methoxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511037A
Other languages
English (en)
Other versions
ES511037A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unibios SpA
Original Assignee
Unibios SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unibios SpA filed Critical Unibios SpA
Publication of ES511037A0 publication Critical patent/ES511037A0/es
Publication of ES8302654A1 publication Critical patent/ES8302654A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO 1-(4-CLOROBENZOILO)-5-METOXI-2-METIL-3-INDOLILACETOHIDROXAMICO. CONSISTE EN LA REACCION DEL ACIDO 1-(4-CLOROBENZOILO)-5-METOXI-2-METIL-3-INDOLILACETICO CON UN HALOCARBONATO DE FORMULA HAL<024>COOR, EN LA QUE HAL ES HALOGENO Y R ES UN ALQUILO C <003> , EN PRESENCIA DE UNA BASE QUE CONTIENE NITROGENO ORGANICO TERCIARIO; SEGUIDA DE LA REACCION CON HIDROXILAMINA, EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ENTRE -10<025>C Y 50<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIINFLAMATORIAS.
ES511037A 1981-04-03 1982-04-01 "procedimiento para la preparacion de acido 1-(4-cloro-benzoilo)-5-metoxi-2-metilo-3-indolil-acetohidroxamico". Expired ES8302654A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20918/81A IT1144692B (it) 1981-04-03 1981-04-03 Nuovo procedimento per la preparazione dell'acido 1-p-clorobenzoil-2-metil-5-metossi-2-indolacetoidrossammico

Publications (2)

Publication Number Publication Date
ES511037A0 ES511037A0 (es) 1983-02-01
ES8302654A1 true ES8302654A1 (es) 1983-02-01

Family

ID=11174057

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511037A Expired ES8302654A1 (es) 1981-04-03 1982-04-01 "procedimiento para la preparacion de acido 1-(4-cloro-benzoilo)-5-metoxi-2-metilo-3-indolil-acetohidroxamico".

Country Status (11)

Country Link
US (1) US4455432A (es)
JP (1) JPS57176955A (es)
KR (1) KR860000649B1 (es)
BE (1) BE892645A (es)
CA (1) CA1164456A (es)
DE (1) DE3211663A1 (es)
ES (1) ES8302654A1 (es)
FR (1) FR2503154A1 (es)
GB (1) GB2097388B (es)
IT (1) IT1144692B (es)
NL (1) NL8201420A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59204172A (ja) * 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2397508A (en) * 1943-05-29 1946-04-02 Standard Oil Co Hydroxamic acids
US2785191A (en) * 1952-07-03 1957-03-12 Ciba Pharm Prod Inc Acylmercapto-alkylamines and process for the manufacture thereof
FR1579495A (es) * 1968-01-22 1969-08-29
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
DE2008332C3 (de) * 1970-02-23 1980-05-22 Istituto Biologico Chemioterapico Abc S.P.A., Turin (Italien) 2-Methyl-S-methoxy-3-indolylacetohydroxamsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2413125C2 (de) * 1974-03-15 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Indolylacetylaminosäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneipräparate
US4186133A (en) * 1978-02-23 1980-01-29 Istituto Biologico Chemioterapico "Abc" S.P.A. Process for the preparation of an indole-3-acetohydroxamic acid

Also Published As

Publication number Publication date
GB2097388A (en) 1982-11-03
DE3211663C2 (es) 1990-12-13
ES511037A0 (es) 1983-02-01
GB2097388B (en) 1985-01-03
KR860000649B1 (ko) 1986-05-28
US4455432A (en) 1984-06-19
JPS57176955A (en) 1982-10-30
JPH0149151B2 (es) 1989-10-23
IT1144692B (it) 1986-10-29
NL8201420A (nl) 1982-11-01
IT8120918A0 (it) 1981-04-03
BE892645A (nl) 1982-07-16
DE3211663A1 (de) 1982-10-21
KR830010068A (ko) 1983-12-26
CA1164456A (en) 1984-03-27
FR2503154B1 (es) 1985-05-17
FR2503154A1 (fr) 1982-10-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303