[go: up one dir, main page]

ES8302624A1 - "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxiacetico". - Google Patents

"procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxiacetico".

Info

Publication number
ES8302624A1
ES8302624A1 ES512388A ES512388A ES8302624A1 ES 8302624 A1 ES8302624 A1 ES 8302624A1 ES 512388 A ES512388 A ES 512388A ES 512388 A ES512388 A ES 512388A ES 8302624 A1 ES8302624 A1 ES 8302624A1
Authority
ES
Spain
Prior art keywords
antiinflammatory
analgesic activity
preparation
pharmaceutical compositions
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512388A
Other languages
English (en)
Other versions
ES512388A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ausonia Farmaceutici SRL
Original Assignee
Ausonia Farmaceutici SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ausonia Farmaceutici SRL filed Critical Ausonia Farmaceutici SRL
Publication of ES512388A0 publication Critical patent/ES512388A0/es
Publication of ES8302624A1 publication Critical patent/ES8302624A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO (2'',4''-DIFLUORO-4-BIFENIL)-OXIACETICO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES CON METALES O BASES ORGANICAS; COMPUESTO QUE TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANALGESICA. CONSISTE EN LA REACCION DE LA SAL SODICA DEL 4-(2'',4''-DIFLUORFENIL)-FENOL CON BROMOACETATO DE ETILO, EN UN ALCOHOL INFERIOR, TAL COMO ETANOL, A LA TEMPERATURA DE REFLUJO; SEGUIDA DE LA HIDROLISIS DEL ESTER FORMADO CON UNA DISOLUCION ACUOSA DE UN HIDROXIDO ALCALINO; Y, FINALMENTE, ACIDIFICACION DEL COMPUESTO OBTENIDO CON UN ACIDO MINERAL, TAL COMO ACIDO CLORHIDRICO.
ES512388A 1981-11-24 1982-05-20 "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxiacetico". Expired ES8302624A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT25245/81A IT1195295B (it) 1981-11-24 1981-11-24 Nuovi composti ad atitivita' antiinfiammatoria e analgesica,processo per la loro preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
ES512388A0 ES512388A0 (es) 1983-02-01
ES8302624A1 true ES8302624A1 (es) 1983-02-01

Family

ID=11216117

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512388A Expired ES8302624A1 (es) 1981-11-24 1982-05-20 "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxiacetico".

Country Status (9)

Country Link
US (1) US4440786A (es)
EP (1) EP0080011A1 (es)
JP (1) JPS5892635A (es)
KR (1) KR830010037A (es)
CA (1) CA1185616A (es)
ES (1) ES8302624A1 (es)
IT (1) IT1195295B (es)
PT (1) PT74938A (es)
ZA (1) ZA823486B (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3755603A (en) * 1970-07-01 1973-08-28 Syntex Corp Biphenylyloxyacetic acids in pharmaceutical compositions
US4021479A (en) * 1971-03-17 1977-05-03 Boehringer Ingelheim Gmbh Derivatives of 4-(4-biphenylyl)-butyric acid
US3948973A (en) * 1972-08-29 1976-04-06 Sterling Drug Inc. Halocyclopropyl substituted phenoxyalkanoic acids
US4188491A (en) * 1975-04-04 1980-02-12 The Boots Company Limited Preparation of therapeutic compounds
US4151302A (en) * 1975-06-28 1979-04-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Araliphatic dihalogen compounds composition and method of use
US4189499A (en) * 1977-03-16 1980-02-19 Biochefarm S.A. Lysine 4-allyloxy-3-chlorophenylacetate and method of its preparation
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
JPS5576840A (en) * 1978-12-01 1980-06-10 Kaken Pharmaceut Co Ltd New oxyacetic acid derivative, its preparation and blood- lipid depressor containing it as active principle
IT1141655B (it) * 1980-02-12 1986-10-08 Schiapparelli Spa Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica

Also Published As

Publication number Publication date
CA1185616A (en) 1985-04-16
ZA823486B (en) 1983-03-30
PT74938A (en) 1982-06-01
IT8125245A0 (it) 1981-11-24
ES512388A0 (es) 1983-02-01
JPS5892635A (ja) 1983-06-02
EP0080011A1 (en) 1983-06-01
KR830010037A (ko) 1983-12-24
US4440786A (en) 1984-04-03
IT1195295B (it) 1988-10-12
JPS6124375B2 (es) 1986-06-10

Similar Documents

Publication Publication Date Title
AU581442B2 (en) 2-substituted-1, 3-propylidenediphosphonate derivatives, the process for their preparation and pharmaceutical compositions containing them
GB1374367A (en) Propionamide derivative a method of making it and therapeutic compositions containing it
GR74953B (es)
ES8302623A1 (es) "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico".
ES468170A1 (es) Un procedimiento para la preparacion de un nuevo derivado demorfina
GB1530074A (en) Rho-acetamidophenol derivatives the preparation thereof and the use of such derivatives as therapeutic agents
PT83472A (en) Process for preparing improved antiinflammatory compositions containing piroxicam
ES8502076A1 (es) Procedimiento para la preparacion de acido 3b-(3-carboxipropioniloxi)-ursa-9(11),12-dien-28-oico
ES8301895A1 (es) "procedimiento para preparar nuevos acidos 2-amino-3-(halobenzoil)-metilfenilaceticos,sus esteres y sus sales metalicas".
ES8302624A1 (es) "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxiacetico".
IE43872L (en) 2,9-dioxatricyclo [4.3.1.0(3,7)] decanes
GB1518621A (en) Analgesic composition
AU568101B2 (en) Pharmaceutical benzazepines and benzdiazepines
JPS57118563A (en) Indole derivative and preparation of peptide
ES8407478A1 (es) Un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina.
ES8304924A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido glutamil-diaminopimelico que contiene una b-lactama.
ES8304925A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido &-glutamil-diaminopimelilo.
ES8307712A1 (es) "procedimiento para la preparacion de n-(2,6-diclorofenil)-acetamidina".
JPS51115489A (en) Method for preparing antibiotics
ES2004255A6 (es) Procedimiento de preparar compuestos del tipo de las piracinas y analogos.
JPS55102572A (en) 5-fluorouracil derivative and its preparation
ES479233A1 (es) Procedimiento para la obtencion de derivados de antraquinona.
ZA824414B (en) A compound with analgesic, antiinflammatory and antipyretic activity, process for the preparation thereof and pharmaceutical compositions therefrom
JPS5248640A (en) Process for preparation of alpha-substituted-phenyl-alkane-carboxylic acids their derivatives
DE3070171D1 (en) 1-(2,6-dichlorophenyl)-2-quinolinoneimine-3-carboxylic acid, production process therefor and anti-inflammatory and analgesic composition containing the compound