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ES484022A1 - Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol - Google Patents

Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol

Info

Publication number
ES484022A1
ES484022A1 ES484022A ES484022A ES484022A1 ES 484022 A1 ES484022 A1 ES 484022A1 ES 484022 A ES484022 A ES 484022A ES 484022 A ES484022 A ES 484022A ES 484022 A1 ES484022 A1 ES 484022A1
Authority
ES
Spain
Prior art keywords
derivatives
pyrimido
preparation
processes
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484022A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES484022A1 publication Critical patent/ES484022A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de derivados de pirimido (1,6-a)indol, de la fórmula general I **(Fórmula)** en donde R1 es hidrógeno, alquilo inferior, alcoxilo inferior, benciloxilo, alcanoiloxilo inferior, halo, nitro o trifluorometilo; R2 es hidrógeno, alquilo inferior, ciclo-alquilo(inferior), fenil-alquilo(inferior), fenilo o un radical de la fórmula - (CH2)h-NR6R7 donde h es un número entero comprendido entre 0 y 6, R6 es alquilo inferior y R7 es hidrógeno o alquilo inferior o R6 y R7 juntos forman una cadena de la fórmula -(CH2)k- en donde k es un número entero comprendido entre 4 y 7; R3 es hidrógeno, alquilo inferior, bencilo o fenilo; R4 es alquilo inferior; o R3 y R4 juntos forman una cadena de la fórmula -(CH2)m- en donde m es un número entero comprendido entre 5 y 7; y R5 es bromo, cloro, hidroxilo.
ES484022A 1978-09-11 1979-09-10 Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol Expired ES484022A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/941,816 US4307234A (en) 1978-09-11 1978-09-11 Pyrimido[1,6-a]indole derivatives

Publications (1)

Publication Number Publication Date
ES484022A1 true ES484022A1 (es) 1980-04-16

Family

ID=25477108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES484022A Expired ES484022A1 (es) 1978-09-11 1979-09-10 Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol

Country Status (5)

Country Link
US (1) US4307234A (es)
EP (1) EP0008950A3 (es)
CA (1) CA1128935A (es)
ES (1) ES484022A1 (es)
WO (1) WO1980000537A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
DE3170801D1 (en) * 1980-03-04 1985-07-11 Ciba Geigy Ag Amidines, process for their production, pharmaceutical preparations containing them and their use
ZA824382B (en) * 1981-07-07 1984-02-29 Wyeth John & Brother Ltd Anti-obesity agents
DE3270406D1 (en) * 1981-08-03 1986-05-15 Ciba Geigy Ag Amidines, process for their preparation, pharmaceutical compounds containing them and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2187813A (en) * 1936-05-30 1940-01-23 Gen Aniline Works Inc Vat dyestuff of the phthaloyl quinazoline series
US3410851A (en) * 1963-09-03 1968-11-12 Miles Lab Derivatives of flavone
US3635966A (en) * 1969-10-22 1972-01-18 Robins Co Inc A H 6-substituted-indolo(1 2-c)quinazolines
US3649626A (en) * 1970-04-27 1972-03-14 Warner Lambert Co Fused ring systems containing (1 3)oxazine
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
SU481613A1 (ru) * 1973-04-27 1975-08-25 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.Орджоникидзе Способ получени замещенных индоло /1,2-с/ хиназолинов
SU539885A1 (ru) * 1975-07-18 1976-12-25 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Имени С.Орджоникидзе Способ получени производных 12-ацетиламиноиндоло /1,2-с/ хиназолинов

Also Published As

Publication number Publication date
WO1980000537A1 (en) 1980-04-03
CA1128935A (en) 1982-08-03
EP0008950A2 (en) 1980-03-19
US4307234A (en) 1981-12-22
EP0008950A3 (en) 1980-06-11

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