[go: up one dir, main page]

ES479138A1 - Un procedimiento para la produccion de nuevos derivados car-bostirilicos. - Google Patents

Un procedimiento para la produccion de nuevos derivados car-bostirilicos.

Info

Publication number
ES479138A1
ES479138A1 ES479138A ES479138A ES479138A1 ES 479138 A1 ES479138 A1 ES 479138A1 ES 479138 A ES479138 A ES 479138A ES 479138 A ES479138 A ES 479138A ES 479138 A1 ES479138 A1 ES 479138A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
cycloalkyl
hydrogen
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479138A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES479138A1 publication Critical patent/ES479138A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Un procedimiento para la producción de nuevos derivados carbostirilicos de fórmula: ***1 (Ver fórmula 1) donde R1 es un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un grupo alquenilo de 2 a 4 átomos de carbono o un grupo fenilalquilo formados por la combinación de un grupo fenilo y un grupo alquileno de 1 a 4 átomos de carbono.
ES479138A 1977-06-10 1979-03-30 Un procedimiento para la produccion de nuevos derivados car-bostirilicos. Expired ES479138A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (1)

Publication Number Publication Date
ES479138A1 true ES479138A1 (es) 1979-07-01

Family

ID=27284068

Family Applications (2)

Application Number Title Priority Date Filing Date
ES470690A Expired ES470690A1 (es) 1977-06-10 1978-06-09 Un procedimiento para la produccion de nuevos derivados car-bostirilicos
ES479138A Expired ES479138A1 (es) 1977-06-10 1979-03-30 Un procedimiento para la produccion de nuevos derivados car-bostirilicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES470690A Expired ES470690A1 (es) 1977-06-10 1978-06-09 Un procedimiento para la produccion de nuevos derivados car-bostirilicos

Country Status (21)

Country Link
US (1) US4298739A (es)
AR (2) AR224345A1 (es)
AT (1) AT367038B (es)
AU (1) AU510138B2 (es)
CA (1) CA1098907A (es)
CH (1) CH636087A5 (es)
DE (1) DE2825048A1 (es)
DK (1) DK149449C (es)
ES (2) ES470690A1 (es)
FI (1) FI69300C (es)
FR (1) FR2393795B1 (es)
GB (1) GB2002745B (es)
IE (1) IE46852B1 (es)
IT (1) IT1108326B (es)
MX (1) MX5527E (es)
NL (1) NL178074C (es)
NO (1) NO148813C (es)
NZ (1) NZ187452A (es)
PH (1) PH14670A (es)
PT (1) PT68157A (es)
SE (1) SE444562B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
HU191316B (en) * 1984-02-15 1987-02-27 Syntex Usa Inc.,Us Process for producing (2-oxo-1,2,3,5-tetrahydro-imidazo /2,1-b/ quinazoline)-oxy-lakyl-amides and pharmacutical compositions containing them
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (es) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
CA2093633A1 (en) * 1991-08-23 1993-02-24 Seiji Sato Carbostyril derivative and platelets aggregation inhibitory agent
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
CA2771136A1 (en) 2009-08-21 2011-02-24 Otsuka Pharmaceutical Co., Ltd. Process for producing benzo[b][1,4]diazepine-2,4-dione compound
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (es) * 1972-12-14 1977-10-03
JPS5234629B2 (es) * 1973-02-03 1977-09-05
NL179275C (nl) * 1973-10-24 1986-08-18 Otsuka Pharma Co Ltd Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DK149449C (da) 1986-11-24
GB2002745B (en) 1982-02-17
FI69300C (fi) 1986-01-10
IT7868355A0 (it) 1978-06-09
ES470690A1 (es) 1979-10-16
PT68157A (en) 1978-07-01
DK149449B (da) 1986-06-16
AT367038B (de) 1982-05-25
DK254878A (da) 1979-02-09
SE444562B (sv) 1986-04-21
DE2825048C2 (es) 1991-05-08
SE7806710L (sv) 1978-12-11
US4298739A (en) 1981-11-03
AR225755A1 (es) 1982-04-30
DE2825048A1 (de) 1978-12-14
AU3686678A (en) 1979-12-13
GB2002745A (en) 1979-02-28
FR2393795B1 (fr) 1986-07-25
NZ187452A (en) 1980-05-27
FI69300B (fi) 1985-09-30
MX5527E (es) 1983-09-23
NO782022L (no) 1978-12-12
CH636087A5 (de) 1983-05-13
AR224345A1 (es) 1981-11-30
AU510138B2 (en) 1980-06-12
PH14670A (en) 1981-10-30
IE781104L (en) 1978-12-10
ATA421378A (de) 1981-10-15
FR2393795A1 (fr) 1979-01-05
NO148813C (no) 1983-12-21
NO148813B (no) 1983-09-12
IT1108326B (it) 1985-12-09
FI781811A (fi) 1978-12-11
CA1098907A (en) 1981-04-07
NL7806245A (nl) 1978-12-12
NL178074C (nl) 1986-01-16
IE46852B1 (en) 1983-10-05

Similar Documents

Publication Publication Date Title
ES470690A1 (es) Un procedimiento para la produccion de nuevos derivados car-bostirilicos
ES486992A1 (es) Un procedimiento para la preparacion de un derivado de car- boestirilo
AU6128590A (en) Novel compounds
DE2960820D1 (en) Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them
SE8006498L (sv) Karbostyrilderivat samt forfarande for framstellning av dem
SE8403801D0 (sv) Nya bensotiazepiner med kardiovaskuler anvendbarhet, forfarande for framstellning derav och farmaceutiska kompositioner som innehaller dem
DE3661913D1 (en) Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them
EP0757988A4 (en) IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
SE8304071L (sv) Nya piperazinderivat
NO822948L (no) Analogifremgangsmaate for fremstilling av heterocykliske forbindelser.
EP0335979A4 (en) Thienopyrimidine derivatives
ES8203867A1 (es) Procedimiento para la obtencion de derivados de benzotiazol
AU598229B2 (en) Novel indenothiazole derivatives and process for their preparation
EP0383318A3 (en) Aralkylamine compounds
NZ332575A (en) Sulfonamide-substituted benzopyran derivatives, processes for preparation, medicament use and compositions comprising them
EP0347880A3 (en) Imidazo[2,1-b]benzothiazole compounds and antiulcer compositions containing the same
ATE29496T1 (de) Tetrahydro-beta-carbolin-derivate und verfahren fuer ihre herstellung.
ES8200113A1 (es) Un procedimiento para la preparacion de derivados de cefalosporina.
IE801382L (en) Piperidines.
EP0116255A3 (en) Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives
ES8602785A1 (es) Procedimiento para preparar derivados de pirazolpiridina
EP0461264A4 (en) Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
SE8701524L (sv) Nya sulfonamider och deras framstaellningsfoerfarande
ATE129702T1 (de) Sulfonamidderivat und dieses enthaltende arzneimittel.
EP0280841A3 (en) Organo-silicone compounds and use thereof

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202