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ES478325A1 - Pyridol(2,1-b)quinazoline derivatives - Google Patents

Pyridol(2,1-b)quinazoline derivatives

Info

Publication number
ES478325A1
ES478325A1 ES478325A ES478325A ES478325A1 ES 478325 A1 ES478325 A1 ES 478325A1 ES 478325 A ES478325 A ES 478325A ES 478325 A ES478325 A ES 478325A ES 478325 A1 ES478325 A1 ES 478325A1
Authority
ES
Spain
Prior art keywords
hydroxide
bases
sodium
pyridol
ethanolate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478325A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES478325A1 publication Critical patent/ES478325A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds form pharmaceutically acceptable salts with bases. Examples of these bases are alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide and the like; alkaline earth hydroxides, such as calcium hydroxide, barium hydroxide and the like; sodium alkoxide, such as sodium ethanolate, potassium ethanolate and the like; organic bases such as piperidine, diethylamine, N-methylglucamine and the like. (Machine-translation by Google Translate, not legally binding)
ES478325A 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives Expired ES478325A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78093977A 1977-03-24 1977-03-24
US87156478A 1978-01-23 1978-01-23

Publications (1)

Publication Number Publication Date
ES478325A1 true ES478325A1 (en) 1979-11-01

Family

ID=27119777

Family Applications (13)

Application Number Title Priority Date Filing Date
ES468126A Expired ES468126A1 (en) 1977-03-24 1978-03-22 Pyridol(2,1-b)quinazoline derivatives
ES468127A Expired ES468127A1 (en) 1977-03-24 1978-03-22 Pyridol(2,1-b)quinazoline derivatives
ES478332A Expired ES478332A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478325A Expired ES478325A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478326A Expired ES478326A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478323A Expired ES478323A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478333A Expired ES478333A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478330A Expired ES478330A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478329A Expired ES478329A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478328A Expired ES478328A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478331A Expired ES478331A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478324A Expired ES478324A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478327A Expired ES478327A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES468126A Expired ES468126A1 (en) 1977-03-24 1978-03-22 Pyridol(2,1-b)quinazoline derivatives
ES468127A Expired ES468127A1 (en) 1977-03-24 1978-03-22 Pyridol(2,1-b)quinazoline derivatives
ES478332A Expired ES478332A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives

Family Applications After (9)

Application Number Title Priority Date Filing Date
ES478326A Expired ES478326A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478323A Expired ES478323A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478333A Expired ES478333A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478330A Expired ES478330A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478329A Expired ES478329A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478328A Expired ES478328A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478331A Expired ES478331A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478324A Expired ES478324A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives
ES478327A Expired ES478327A1 (en) 1977-03-24 1979-02-16 Pyridol(2,1-b)quinazoline derivatives

Country Status (23)

Country Link
JP (2) JPS53119896A (en)
AR (3) AR218060A1 (en)
AT (2) AT367050B (en)
AU (2) AU521352B2 (en)
DE (2) DE2812586A1 (en)
DK (2) DK128878A (en)
ES (13) ES468126A1 (en)
FI (2) FI780918A (en)
FR (2) FR2384770A1 (en)
GB (2) GB1601991A (en)
GR (2) GR73170B (en)
HU (1) HU180782B (en)
IE (1) IE46505B1 (en)
IL (2) IL54326A (en)
IT (2) IT1093710B (en)
LU (2) LU79290A1 (en)
MC (2) MC1186A1 (en)
NL (2) NL7803122A (en)
NO (2) NO781053L (en)
NZ (2) NZ186760A (en)
PH (2) PH13915A (en)
PT (2) PT67821B (en)
SE (2) SE7803418L (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557425C2 (en) * 1975-12-19 1987-03-19 C.H. Boehringer Sohn, 6507 Ingelheim 11-Oxo-11-H-pyrido[2,1-b]-quinazoline-2-carboxylic acid and its salts, processes for their preparation and medicaments
DE2845766A1 (en) * 1978-10-18 1980-04-30 Schering Ag PYRIDO ANGLE CLAMP ON 2,1-B ANGLE CLAMP ON -CHINAZOLINONE DERIVATIVES, THEIR PRODUCTION AND USE
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
ES511866A0 (en) * 1982-04-30 1983-06-01 Lafarquim "PROCEDURE FOR OBTAINING 2-ISOPROPIL PIRIDO (2-1-B) QUINAZOLINAS AND ITS NON-TOXIC SALTS WITH ANTIANAPHILACTIC ACTIVITY".
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
DE3300477A1 (en) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim NEW HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE
JPS62238264A (en) * 1986-04-04 1987-10-19 Nippon Tokushu Noyaku Seizo Kk 2-halo-5-acetylpyridine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation

Also Published As

Publication number Publication date
GR72948B (en) 1984-01-17
NZ186759A (en) 1981-03-16
PT67821B (en) 1980-03-04
NL7803122A (en) 1978-09-26
FR2384771B1 (en) 1980-04-04
ES478324A1 (en) 1979-11-01
GR73170B (en) 1983-02-14
AU521096B2 (en) 1982-03-18
FR2384770B1 (en) 1980-10-24
NO781053L (en) 1978-09-26
ES478330A1 (en) 1979-11-01
GB1601991A (en) 1981-11-04
AT367050B (en) 1982-05-25
NO781051L (en) 1978-09-26
GB1601371A (en) 1981-10-28
AU521352B2 (en) 1982-04-01
IL54326A (en) 1982-04-30
AU3447578A (en) 1979-09-27
IL54326A0 (en) 1978-06-15
ES478323A1 (en) 1979-11-01
NZ186760A (en) 1981-03-16
PT67821A (en) 1978-04-01
AR218480A1 (en) 1980-06-13
ES478327A1 (en) 1979-11-01
PH14130A (en) 1981-02-26
AU3447478A (en) 1979-09-27
ES478332A1 (en) 1979-11-16
IT7821655A0 (en) 1978-03-24
PT67820A (en) 1978-04-01
IT7821578A0 (en) 1978-03-23
DK128878A (en) 1978-09-25
ES478329A1 (en) 1979-11-01
MC1185A1 (en) 1978-12-22
DK132778A (en) 1978-09-25
IT1093710B (en) 1985-07-26
ES468126A1 (en) 1979-09-01
ES478333A1 (en) 1979-11-16
ES478331A1 (en) 1979-11-16
IL54328A0 (en) 1978-06-15
ES478326A1 (en) 1979-11-01
SE7803419L (en) 1978-09-25
LU79293A1 (en) 1979-05-25
PH13915A (en) 1980-11-04
ATA210478A (en) 1981-10-15
JPS53119896A (en) 1978-10-19
IT1095493B (en) 1985-08-10
IE46505B1 (en) 1983-06-29
ES478328A1 (en) 1979-11-01
FI780918A (en) 1978-09-25
MC1186A1 (en) 1978-12-22
LU79290A1 (en) 1979-05-25
IE780582L (en) 1978-09-24
HU180782B (en) 1983-04-29
FR2384771A1 (en) 1978-10-20
AR225415A1 (en) 1982-03-31
ATA210278A (en) 1981-10-15
SE7803418L (en) 1978-09-25
AR218060A1 (en) 1980-05-15
AT367051B (en) 1982-05-25
DE2812586A1 (en) 1978-09-28
NL7803112A (en) 1978-09-26
IL54328A (en) 1982-03-31
FR2384770A1 (en) 1978-10-20
JPS53119897A (en) 1978-10-19
ES468127A1 (en) 1979-09-16
DE2812585A1 (en) 1978-09-28
FI780917A (en) 1978-09-25

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