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ES476314A1 - Thio propionamides, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Thio propionamides, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
ES476314A1
ES476314A1 ES476314A ES476314A ES476314A1 ES 476314 A1 ES476314 A1 ES 476314A1 ES 476314 A ES476314 A ES 476314A ES 476314 A ES476314 A ES 476314A ES 476314 A1 ES476314 A1 ES 476314A1
Authority
ES
Spain
Prior art keywords
lower alkyl
group
formula
amino
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476314A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES476314A1 publication Critical patent/ES476314A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The invention provides compounds of the formula < IMAGE > in which R is a hydrogen atom, a lower alkyl, lower alkenyl or aryl-lower alkyl group or the acyl radical of a lower alkyl-carboxylic acid or an aryl- carboxylic acid each having up to 10 carbon atoms R1 is a hydroxy, lower alkoxy, di- (lower alkyl)-amino-lower alkoxy, amino, monosubstituted amino, disubstituted amino or dihydroxy-lower alkyl group A and B together are a lower alkylene group of the formula (CH2)m-CH2-, a group of the formula < IMAGE > a group of the formula (CH2)ml- CH = CH or a disubstituted lower alkylene group of the formula < IMAGE > Z is sulphur or a sulphinyl or sulphonyl group R' is a hydrogen atom or a lower alkyl group R'' is a lower alkyl group n is zero or 1 m is 1 or 2 m1 is zero, 1 or 2 and m2 is 1 or 2 and their diastereoisomers, optically active isomers and salts with inorganlc and organic bases. The invention also provides a process for preparing such compounds, and pharmaceutical compositions containing them. The compounds may be used in the treatment of hypertension.
ES476314A 1977-12-22 1978-12-22 Thio propionamides, processes for their preparation and pharmaceutical compositions containing them Expired ES476314A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (en) 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

Publications (1)

Publication Number Publication Date
ES476314A1 true ES476314A1 (en) 1979-04-16

Family

ID=9199179

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476314A Expired ES476314A1 (en) 1977-12-22 1978-12-22 Thio propionamides, processes for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
AR (1) AR222815A1 (en)
BE (1) BE872972A (en)
DD (1) DD142545A5 (en)
DE (1) DE2854877A1 (en)
ES (1) ES476314A1 (en)
FR (1) FR2412537A1 (en)
GB (1) GB2014132B (en)
GR (1) GR66839B (en)
IT (1) IT1158184B (en)
OA (1) OA06139A (en)
PT (1) PT68966A (en)
SE (1) SE7813180L (en)
SU (1) SU860696A1 (en)
ZA (1) ZA787196B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1109475A (en) * 1978-07-27 1981-09-22 Miguel A. Ondetti Thiopropanoylamino acid derivatives
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
ZA802709B (en) * 1979-05-30 1981-05-27 Merrell Toraude & Co N-acyl-amino acid derivatives
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4284561A (en) 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
BE872972A (en) 1979-06-21
FR2412537B1 (en) 1981-10-16
SE7813180L (en) 1979-06-23
GB2014132B (en) 1982-08-11
ZA787196B (en) 1979-11-28
DE2854877A1 (en) 1979-06-28
IT1158184B (en) 1987-02-18
DD142545A5 (en) 1980-07-02
GB2014132A (en) 1979-08-22
IT7852406A0 (en) 1978-12-21
PT68966A (en) 1979-01-01
SU860696A1 (en) 1981-08-30
OA06139A (en) 1981-06-30
GR66839B (en) 1981-05-04
FR2412537A1 (en) 1979-07-20
AR222815A1 (en) 1981-06-30

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