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ES465366A2 - Un procedimiento de preparacion de derivados de metoxi-2- benzamidas. - Google Patents

Un procedimiento de preparacion de derivados de metoxi-2- benzamidas.

Info

Publication number
ES465366A2
ES465366A2 ES465366A ES465366A ES465366A2 ES 465366 A2 ES465366 A2 ES 465366A2 ES 465366 A ES465366 A ES 465366A ES 465366 A ES465366 A ES 465366A ES 465366 A2 ES465366 A2 ES 465366A2
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
alcohol
atom
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465366A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7639034A external-priority patent/FR2378520A1/fr
Priority claimed from FR7639033A external-priority patent/FR2375167A1/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES465366A2 publication Critical patent/ES465366A2/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento de preparación de derivados de metoxi-2-benzamidas; según los cuales cuando dichos derivados en forma de racematos o enantiómerosresponden a la fórmula (I)***(ver fórmula)***En la que R1 representa un átomo de cloroo un radical SO2R5 en el que R5 es un alcohilo que tiene de a 4 átomos de carbonoo un radical SO2NR6R7 en el que R6 y R7que son idénticos o diferentesrepresentanindependientemente uno del otroun átomo de hidrógeno o un radical alcohilo de 1 a 4 átomos de carbono; R2 representa un átomo de hidrógeno o un alcohilo de 1 a 4 átomos de carbono; R3 y R4 representaindependientemente uno del otroun átomo de halógeno o un radical trifluorometilotrrifluorometoxitrifluorometiltioalcoxi de 1 a 4 átomos de carbonoo alcohilo de 1 a 4 átomos de carbono; y R5 representa un átomo de hidrógeno o de halógenoo un radical trifluorometilotrrifluorometoxitrifluorometiltioalcoxi de 1 a 4 átomos de carbonoo alcohilo de 1 a 4 átomos de carbono; así como sus sales de adición de ácidos farmacéuticamente aceptables.
ES465366A 1976-12-24 1977-12-23 Un procedimiento de preparacion de derivados de metoxi-2- benzamidas. Expired ES465366A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7639034A FR2378520A1 (fr) 1976-12-24 1976-12-24 Derives de methoxy-2 benzamides
FR7639033A FR2375167A1 (fr) 1976-12-24 1976-12-24 Derives de trifluoromethyl-3 benzene

Publications (1)

Publication Number Publication Date
ES465366A2 true ES465366A2 (es) 1978-09-16

Family

ID=26219761

Family Applications (1)

Application Number Title Priority Date Filing Date
ES465366A Expired ES465366A2 (es) 1976-12-24 1977-12-23 Un procedimiento de preparacion de derivados de metoxi-2- benzamidas.

Country Status (14)

Country Link
JP (1) JPS5382771A (es)
AU (1) AU3192177A (es)
DE (1) DE2757406A1 (es)
DK (1) DK575877A (es)
ES (1) ES465366A2 (es)
FI (1) FI773911A (es)
GB (1) GB1556566A (es)
GR (1) GR66082B (es)
IL (1) IL53680A0 (es)
LU (1) LU78773A1 (es)
NL (1) NL7714301A (es)
NO (1) NO774402L (es)
NZ (1) NZ186075A (es)
SE (1) SE7714659L (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3005722A1 (de) * 1980-02-15 1981-08-20 Bayer Ag, 5090 Leverkusen Trifluormethylbenzylester, verfahren zu deren herstellung und deren verwendung in schaedlingsbekaempfungsmitteln
CA1157884A (en) * 1980-04-16 1983-11-29 Byron R. Cotter Process for the preparation of trifluoromethylbenzoyl halides

Also Published As

Publication number Publication date
NZ186075A (en) 1979-11-01
LU78773A1 (fr) 1979-07-20
IL53680A0 (en) 1978-03-10
DK575877A (da) 1978-06-25
GR66082B (es) 1981-01-15
NL7714301A (nl) 1978-06-27
JPS5382771A (en) 1978-07-21
NO774402L (no) 1978-06-27
DE2757406A1 (de) 1978-06-29
SE7714659L (sv) 1978-06-25
GB1556566A (en) 1979-11-28
AU3192177A (en) 1979-06-28
FI773911A (fi) 1978-06-25

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170706