ES455986A1 - PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. - Google Patents
PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES.Info
- Publication number
- ES455986A1 ES455986A1 ES455986A ES455986A ES455986A1 ES 455986 A1 ES455986 A1 ES 455986A1 ES 455986 A ES455986 A ES 455986A ES 455986 A ES455986 A ES 455986A ES 455986 A1 ES455986 A1 ES 455986A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazoline derivatives
- procedure
- formula
- group
- preparing quinazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para preparar derivados de quinazolina, de fórmula: **(Fórmula)** en la que (i) R1 es un átomo de hidrógeno o un grupo alquilo inferior; (R2)n representa de 1 a 3 sustituyentes opcionales, siendo cada R2 un átomo de hidrógeno o un grupo hidroxi o alcoxi inferior y siendo n de 1 a 3, o constituyendo dos cualquiera de las mitades R2 un grupo metilendioxi o etilendioxi unido a posiciones adyacentes del anillo A; (ii) X representa - (CH2)p-en donde p es 1 a 3; (iii) y está unido a la posición 3 ó 4 del anillo C y representa un grupo de fórmula -Z-CO-NHR6 ó -Z-CS-NHR6.Process for preparing quinazoline derivatives, of the formula: **(Formula)** in which (i) R 1 is a hydrogen atom or a lower alkyl group; (R2)n represents from 1 to 3 optional substituents, each R2 being a hydrogen atom or a hydroxy or lower alkoxy group and n being from 1 to 3, or any two of the R2 moieties constituting a methylenedioxy or ethylenedioxy group attached to positions adjacent to ring A; (ii) X represents -(CH2)p-where p is 1 to 3; (iii) and is attached to the 3 or 4 position of ring C and represents a group of formula -Z-CO-NHR6 or -Z-CS-NHR6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3280574 | 1974-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455986A1 true ES455986A1 (en) | 1978-06-01 |
Family
ID=10344259
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439690A Expired ES439690A1 (en) | 1974-07-25 | 1975-07-24 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
| ES455986A Expired ES455986A1 (en) | 1974-07-25 | 1977-02-16 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
| ES455984A Expired ES455984A1 (en) | 1974-07-25 | 1977-02-16 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
| ES455985A Expired ES455985A1 (en) | 1974-07-25 | 1977-02-16 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439690A Expired ES439690A1 (en) | 1974-07-25 | 1975-07-24 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES455984A Expired ES455984A1 (en) | 1974-07-25 | 1977-02-16 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
| ES455985A Expired ES455985A1 (en) | 1974-07-25 | 1977-02-16 | PROCEDURE FOR PREPARING QUINAZOLINE DERIVATIVES. |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT344178B (en) |
| BE (1) | BE831654A (en) |
| CS (1) | CS192549B2 (en) |
| ES (4) | ES439690A1 (en) |
| HU (1) | HU174961B (en) |
| PL (6) | PL103797B1 (en) |
| SU (5) | SU578874A3 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070004763A1 (en) * | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
-
1975
- 1975-07-08 AT AT525275A patent/AT344178B/en active
- 1975-07-18 PL PL1975193423A patent/PL103797B1/en unknown
- 1975-07-18 PL PL1975193419A patent/PL103798B1/en unknown
- 1975-07-18 HU HU75PI483A patent/HU174961B/en unknown
- 1975-07-18 PL PL1975182162A patent/PL99427B1/en unknown
- 1975-07-18 PL PL1975193422A patent/PL104615B1/en unknown
- 1975-07-18 PL PL1975193420A patent/PL103789B1/en unknown
- 1975-07-18 PL PL1975193421A patent/PL103791B1/en not_active IP Right Cessation
- 1975-07-21 CS CS755147A patent/CS192549B2/en unknown
- 1975-07-23 BE BE158540A patent/BE831654A/en not_active IP Right Cessation
- 1975-07-24 ES ES439690A patent/ES439690A1/en not_active Expired
- 1975-07-25 SU SU7502162232A patent/SU578874A3/en active
-
1976
- 1976-08-02 SU SU762386166A patent/SU858563A3/en active
- 1976-08-10 SU SU762388319A patent/SU613723A3/en active
- 1976-08-10 SU SU762388318A patent/SU634671A3/en active
- 1976-08-10 SU SU762388320A patent/SU625606A3/en active
-
1977
- 1977-02-16 ES ES455986A patent/ES455986A1/en not_active Expired
- 1977-02-16 ES ES455984A patent/ES455984A1/en not_active Expired
- 1977-02-16 ES ES455985A patent/ES455985A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT344178B (en) | 1978-07-10 |
| HU174961B (en) | 1980-04-28 |
| PL193423A1 (en) | 1978-04-24 |
| SU613723A3 (en) | 1978-06-30 |
| SU634671A3 (en) | 1978-11-25 |
| ES455984A1 (en) | 1978-06-01 |
| SU578874A3 (en) | 1977-10-30 |
| PL193420A1 (en) | 1978-04-24 |
| ATA525275A (en) | 1977-11-15 |
| PL103797B1 (en) | 1979-07-31 |
| PL104615B1 (en) | 1979-08-31 |
| ES439690A1 (en) | 1977-07-01 |
| PL193421A1 (en) | 1978-04-24 |
| BE831654A (en) | 1976-01-23 |
| PL103791B1 (en) | 1979-07-31 |
| PL103798B1 (en) | 1979-07-31 |
| CS192549B2 (en) | 1979-08-31 |
| SU625606A3 (en) | 1978-09-25 |
| PL193422A1 (en) | 1978-06-05 |
| ES455985A1 (en) | 1978-06-16 |
| SU858563A3 (en) | 1981-08-23 |
| PL99427B1 (en) | 1978-07-31 |
| PL103789B1 (en) | 1979-07-31 |
| PL193419A1 (en) | 1978-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991007 |