ES455731A1 - Procedimiento para la preparacion de benzamidas disustitui- das en las posiciones 2 y 5. - Google Patents
Procedimiento para la preparacion de benzamidas disustitui- das en las posiciones 2 y 5.Info
- Publication number
- ES455731A1 ES455731A1 ES455731A ES455731A ES455731A1 ES 455731 A1 ES455731 A1 ES 455731A1 ES 455731 A ES455731 A ES 455731A ES 455731 A ES455731 A ES 455731A ES 455731 A1 ES455731 A1 ES 455731A1
- Authority
- ES
- Spain
- Prior art keywords
- benzamides
- disubstituted
- oxime
- same
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 piperazino, benzylpiperazino, piperonylpiperazino, dimethylaminoethylamino, diethylaminoethylamino, pyrrolidinyl-1-substituted-methylamino Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 125000000879 imine group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la preparación de benzamidas disustituidas en las posiciones 2 y 5, que responden a la fórmula general siguiente: **(Fórmula)** en la cual: R es un grupo alcohilo (que posee de 1 a 5 átomos de carbono) o alilo, N=R1-R2 piperazino, bencilpiperazino, piperonilpiperazino, dimetilaminoetilamino, dietilaminoetilamino, pirrolidinil-1 sustituido-metilamino, morfolino o piperidino, R'' es un grupo alcohilo que posee de 1 a 8 átomos de carbono, fenilo o fenilo sustituido, alfa-aminometilo o acrílico, Y es un átomo de oxígeno, un grupo oxima, éter de oxima, éster de oxima o imina, caracterizado porque se prepara una benzamida (I), en la que Y es un átomo de oxígeno, a partir de un cloruro de ácido intermedio (II), que se hace reaccionar con una amina apropiada (III) según la reacción siguiente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7605372A FR2342064A1 (fr) | 1976-02-26 | 1976-02-26 | Benzamides 2,5 disubstitues, leurs procedes de preparation et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455731A1 true ES455731A1 (es) | 1978-01-01 |
Family
ID=9169638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES455731A Expired ES455731A1 (es) | 1976-02-26 | 1977-02-08 | Procedimiento para la preparacion de benzamidas disustitui- das en las posiciones 2 y 5. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4127666A (es) |
| BE (1) | BE850224A (es) |
| CH (1) | CH622498A5 (es) |
| DE (1) | DE2705896C3 (es) |
| ES (1) | ES455731A1 (es) |
| FR (1) | FR2342064A1 (es) |
| GB (1) | GB1571058A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485526A1 (fr) * | 1980-06-24 | 1981-12-31 | Shionogi & Co | Procede de preparation de derives de n-(diethylaminoethyl)-2 - alcoxybenzamide, nouveaux produits ainsi obtenus et leurs utilisations comme produits pharmaceutiques antiemetiques ou pour guerir les troubles gastriques |
| US4820715A (en) * | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| US5011992A (en) * | 1984-06-28 | 1991-04-30 | Bristol-Myers Squibb Company | Pharmacologically active substituted benzamides |
| FR2699533A1 (fr) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications. |
-
1976
- 1976-02-26 FR FR7605372A patent/FR2342064A1/fr active Granted
-
1977
- 1977-01-07 BE BE173953A patent/BE850224A/xx not_active IP Right Cessation
- 1977-01-18 CH CH58977A patent/CH622498A5/fr not_active IP Right Cessation
- 1977-02-01 GB GB4038/77A patent/GB1571058A/en not_active Expired
- 1977-02-08 ES ES455731A patent/ES455731A1/es not_active Expired
- 1977-02-11 DE DE2705896A patent/DE2705896C3/de not_active Expired
- 1977-02-15 US US05/768,893 patent/US4127666A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH622498A5 (es) | 1981-04-15 |
| FR2342064A1 (fr) | 1977-09-23 |
| FR2342064B1 (es) | 1979-10-05 |
| DE2705896A1 (de) | 1977-09-01 |
| BE850224A (fr) | 1977-07-07 |
| US4127666A (en) | 1978-11-28 |
| GB1571058A (en) | 1980-07-09 |
| DE2705896B2 (de) | 1979-04-05 |
| DE2705896C3 (de) | 1979-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |