[go: up one dir, main page]

ES451919A1 - Novel propanolamine ether compound and preparation thereof - Google Patents

Novel propanolamine ether compound and preparation thereof

Info

Publication number
ES451919A1
ES451919A1 ES451919A ES451919A ES451919A1 ES 451919 A1 ES451919 A1 ES 451919A1 ES 451919 A ES451919 A ES 451919A ES 451919 A ES451919 A ES 451919A ES 451919 A1 ES451919 A1 ES 451919A1
Authority
ES
Spain
Prior art keywords
radical
alkyl
formula
see formula
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES451919A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of ES451919A1 publication Critical patent/ES451919A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A process for obtaining ethers of propanolamines of the formula: ** (see formula) ** Wherein ar represents either an aryl residue which can carry one or more substituents selected from the halogen atoms, the trifluoromethyl radical and the alkyl or alkoxy radicals, or another aromatic group such as the pyridyl radical; r 'represents an alkyl or cycloalkyl radical or an aryl radical which can carry one or more substituents selected from the halogen atoms, the trifluoromethyl radical and the alkyl or alkoxy radicals; r represents a linear or branched alkyl chain, an arylalkoyl radical or an aryl radical, and a represents a tertiary amino group such as pyrrolidino, piperidino, morpholino or dialcohilamino, characterized in that it consists in reacting by reflux heating in a solvent a 3-alkoxy-2-chloropropylamine of the formula is aromatic. ** (see formula) ** With an anilide of the type (see formula) previously sodated by an appropriate agent. (Machine-translation by Google Translate, not legally binding)
ES451919A 1975-09-30 1976-09-28 Novel propanolamine ether compound and preparation thereof Expired ES451919A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7529850A FR2326179A1 (en) 1975-09-30 1975-09-30 Propanolamine ethers for prolonged treatment of angina pectoris - comprise (3)-tert. amino (2)-aryl-acyl-amino-propanol ethers

Publications (1)

Publication Number Publication Date
ES451919A1 true ES451919A1 (en) 1977-08-16

Family

ID=9160624

Family Applications (1)

Application Number Title Priority Date Filing Date
ES451919A Expired ES451919A1 (en) 1975-09-30 1976-09-28 Novel propanolamine ether compound and preparation thereof

Country Status (9)

Country Link
JP (1) JPS5242831A (en)
AU (1) AU1786776A (en)
BE (1) BE845630A (en)
DE (1) DE2643252A1 (en)
ES (1) ES451919A1 (en)
FR (1) FR2326179A1 (en)
GR (1) GR61278B (en)
NL (1) NL7610790A (en)
ZA (1) ZA765522B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504925A1 (en) * 1981-05-04 1982-11-05 Cerm Cent Europ Rech Mauvernay N-2-amino 3-alkoxy or phenoxy-propyl urea and thiourea derivs. - are cardiovascular agents esp. used to treat arrhythmia
TW201249795A (en) * 2010-11-30 2012-12-16 Astrazeneca Ab New IKACh blockers

Also Published As

Publication number Publication date
JPS5242831A (en) 1977-04-04
ZA765522B (en) 1977-08-31
DE2643252A1 (en) 1977-03-31
NL7610790A (en) 1977-04-01
FR2326179A1 (en) 1977-04-29
AU1786776A (en) 1978-03-23
GR61278B (en) 1978-10-17
BE845630A (en) 1977-02-28

Similar Documents

Publication Publication Date Title
ES410730A1 (en) 1-aroylalkyl-4-diphenylmethyl piperidines
ES467288A1 (en) N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides
ES444523A1 (en) Additives for functional fluids
ES462422A1 (en) Sulfonylglycolic anilide fungicides
ES393496A1 (en) Cerivatives of 2-pyrrolidinone
ES409944A1 (en) Derivatives of pyrroleacetic acids salts thereof and their process of preparation
ES451919A1 (en) Novel propanolamine ether compound and preparation thereof
ES423058A1 (en) 3-(isopropyl amino alkoxy)-2-phenyl-isoindolin-1-ones
ES454824A1 (en) Derivatives of imidazo 1,2-a pyridine
ES395766A1 (en) Procedure for the obtaining of derivatives of hidantoin. (Machine-translation by Google Translate, not legally binding)
ES325471A1 (en) Procedure for the manufacture of dibenzotiacin derivatives. (Machine-translation by Google Translate, not legally binding)
ES393159A1 (en) Certain 3-acetamido or 3-benzamido-6-hydroxy-2-1-h-pyridones
ES424088A1 (en) Novel organotin compounds
ES451293A1 (en) A procedure for the preparation of tienotiacin derivatives. (Machine-translation by Google Translate, not legally binding)
ES274333A1 (en) Procedure for the preparation of new compounds of 1,4-benzodioxane and 1,5-benzodioxepane (Machine-translation by Google Translate, not legally binding)
ES332645A1 (en) Procedure for the preparation of new N-heterocicles. (Machine-translation by Google Translate, not legally binding)
ES424720A1 (en) Process for preparing sulphoxides
ES385857A1 (en) Procedure for the obtaining of terciary amines. (Machine-translation by Google Translate, not legally binding)
ES451084A1 (en) N,n-diethyl-4-(2,4-dinitro-6-alkylsulfonylphenylazo)-2-alkoxy-5-alkyl-carbonylaminoanilines
ES366361A1 (en) Procedure for the preparation of disazous colors (Machine-translation by Google Translate, not legally binding)
ES426553A1 (en) Procedure for preparing 2-formilquinoxalina-1.4-godosox. (Machine-translation by Google Translate, not legally binding)
ES455953A1 (en) Shinki 2 33 jihidoro 11 benzochepin 44 karubokishiamidonoseiho
ES446106A1 (en) A procedure for the production of an aminoalkilic ester of a 2,6-dialkyl (bottom) -4-phenyl substitute-1,4-dihydropyridin-3-carboxylic acid. (Machine-translation by Google Translate, not legally binding)
ES449521A1 (en) A procedure for the preparation of derivatives of 1, 4 - dihidropiridina. (Machine-translation by Google Translate, not legally binding)
ES422455A1 (en) Procedure for preparation of new derivatives of the cumarina. (Machine-translation by Google Translate, not legally binding)