ES450371A1 - Reduction process for the preparation of 4-(hydroxymethyl)-imidazoles - Google Patents
Reduction process for the preparation of 4-(hydroxymethyl)-imidazolesInfo
- Publication number
- ES450371A1 ES450371A1 ES450371A ES450371A ES450371A1 ES 450371 A1 ES450371 A1 ES 450371A1 ES 450371 A ES450371 A ES 450371A ES 450371 A ES450371 A ES 450371A ES 450371 A1 ES450371 A1 ES 450371A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxymethyl
- preparation
- formula
- imidazoles
- reduction process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A process for the preparation of a 4- (hydroxymethyl) imidazole compound of the formula: ** (see formula) ** Wherein r is hydrogen or lower alkyl, characterized in that it comprises reducing 4-imidazolecarboxylic acid ester of the formula: ** (see formula) ** Wherein r is as defined above and r 'is lower alkyl, using an alkali metal or calcium in liquid ammonia, with an additional protonic source. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60627075A | 1975-08-20 | 1975-08-20 | |
| US05/690,476 US4063023A (en) | 1975-08-20 | 1976-05-27 | Process for preparing 4-(hydroxymethyl)imidazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450371A1 true ES450371A1 (en) | 1977-12-01 |
Family
ID=27085194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450371A Expired ES450371A1 (en) | 1975-08-20 | 1976-08-02 | Reduction process for the preparation of 4-(hydroxymethyl)-imidazoles |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6025428B2 (en) |
| AT (1) | AT358574B (en) |
| AU (1) | AU496917B2 (en) |
| CA (1) | CA1064940A (en) |
| DD (1) | DD126871A5 (en) |
| DE (1) | DE2637670C2 (en) |
| DK (1) | DK143749C (en) |
| EG (1) | EG12426A (en) |
| ES (1) | ES450371A1 (en) |
| FI (1) | FI64356C (en) |
| FR (1) | FR2321490A1 (en) |
| GB (1) | GB1562811A (en) |
| GR (1) | GR61130B (en) |
| HU (1) | HU177508B (en) |
| IE (1) | IE44020B1 (en) |
| IL (1) | IL50147A (en) |
| IN (1) | IN147803B (en) |
| LU (1) | LU75612A1 (en) |
| MX (1) | MX3532E (en) |
| NL (1) | NL183581C (en) |
| NO (1) | NO145072C (en) |
| NZ (1) | NZ181647A (en) |
| OA (1) | OA05422A (en) |
| PH (1) | PH13166A (en) |
| PT (1) | PT65369B (en) |
| RO (1) | RO72826A (en) |
| SE (1) | SE415097B (en) |
| YU (1) | YU39616B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ184893A (en) * | 1976-09-21 | 1980-11-28 | Smith Kline French Lab | Pure crystalline form of cimetidine a(n-methyl-n-cyano-n-(-2-(5-methyl-4imidazolyl) methylthio) ethyl)-guanidine andpharmaceutical compositions containing it |
| DE2800148A1 (en) | 1978-01-03 | 1979-07-12 | Basf Ag | PROCESS FOR THE PRODUCTION OF 4-METHYL-5-CHLOROMETHYL-IMIDAZOLE |
| DE2825547A1 (en) * | 1978-06-10 | 1979-12-20 | Basf Ag | 1-HYDROXYMETHYLIMIDAZOLE AND ITS USE AS CHEMICAL INTERMEDIATES |
| JPS5914460B2 (en) * | 1978-12-27 | 1984-04-04 | 相互薬工株式会社 | Production method of cimetidine, an anti-H↓2 receptor |
| JPS63117318U (en) * | 1987-01-24 | 1988-07-29 | ||
| JPH0619559U (en) * | 1992-03-16 | 1994-03-15 | 加藤 利夫 | toothbrush |
-
1976
- 1976-07-14 PT PT65369A patent/PT65369B/en unknown
- 1976-07-14 CA CA256,981A patent/CA1064940A/en not_active Expired
- 1976-07-22 DK DK331976A patent/DK143749C/en not_active IP Right Cessation
- 1976-07-27 IL IL50147A patent/IL50147A/en unknown
- 1976-08-02 NZ NZ181647A patent/NZ181647A/en unknown
- 1976-08-02 ES ES450371A patent/ES450371A1/en not_active Expired
- 1976-08-03 YU YU1913/76A patent/YU39616B/en unknown
- 1976-08-06 SE SE7608831A patent/SE415097B/en not_active IP Right Cessation
- 1976-08-11 FI FI762306A patent/FI64356C/en not_active IP Right Cessation
- 1976-08-13 AT AT606376A patent/AT358574B/en active
- 1976-08-16 GB GB33932/76A patent/GB1562811A/en not_active Expired
- 1976-08-16 FR FR7624871A patent/FR2321490A1/en active Granted
- 1976-08-18 IE IE1834/76A patent/IE44020B1/en unknown
- 1976-08-18 HU HU76SI1536A patent/HU177508B/en not_active IP Right Cessation
- 1976-08-18 DD DD194374A patent/DD126871A5/xx unknown
- 1976-08-18 EG EG511/76A patent/EG12426A/en active
- 1976-08-18 LU LU75612A patent/LU75612A1/xx unknown
- 1976-08-18 MX MX763677U patent/MX3532E/en unknown
- 1976-08-19 GR GR51505A patent/GR61130B/en unknown
- 1976-08-19 JP JP51099204A patent/JPS6025428B2/en not_active Expired
- 1976-08-19 OA OA55920A patent/OA05422A/en unknown
- 1976-08-19 NO NO76762866A patent/NO145072C/en unknown
- 1976-08-20 PH PH18819A patent/PH13166A/en unknown
- 1976-08-20 DE DE2637670A patent/DE2637670C2/en not_active Expired
- 1976-08-20 RO RO7687338A patent/RO72826A/en unknown
- 1976-08-20 NL NLAANVRAGE7609296,A patent/NL183581C/en not_active IP Right Cessation
- 1976-08-20 AU AU17039/76A patent/AU496917B2/en not_active Expired
-
1977
- 1977-07-12 IN IN1065/CAL/77A patent/IN147803B/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981001 |